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Comparative pathological study on H5N1 infection between humans and animals

Research Project

Project/Area Number 21590449
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

ABE Kenji  国立感染症研究所, 感染病理部, 主任研究官 (60130415)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsインフルエンザ / H5N1 / 比較病理 / 感染動物 / 国際協力 / 分子疫学 / 国際研究 / H1N1
Research Abstract

We investigated autopsy cases of tigers and cats infected with H5N1.The animals had eaten fresh chicken or dead pigeon carcass infected with H5N1 and died caused by high fever and severe respiratory disorder. At necropsy, infected animals showed severe hemorrhagic lesion in a systemic organ. H5N1 related antigens was also detected in brain, lung and liver by an immunohistochemical method. Furthermore, a viral gene was isolated from lung tissue in infected animals and its showed high similarity to H5N1 isolated from a human patient in Thailand.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (28 results)

All 2012 2011 2010 2009

All Journal Article (13 results) (of which Peer Reviewed: 4 results) Presentation (13 results) Book (2 results)

  • [Journal Article] Detection of hepatitis B virus DNA in paraffin-embedded intrahepatic and extrahepatic cholangiocarcinoma tissue in the northern Chinese population2012

    • Author(s)
      Yiqi Wu, Tianzhen Wang, Shengqian Ye, Ran Zhao, Xiaohui Bai, Yingying Wu, Kenji Abe, Xiaoming Jin
    • Journal Title

      Human Pathology

      Volume: 43 Pages: 56-61

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Complete coding sequence and molecular analysis of hepatitis A virus from a chimpanzee with fulminant hepatitis2012

    • Author(s)
      Apiradee Theamboonlers, Kenji Abe, Chittima Thongmee, Yong Poovorawan
    • Journal Title

      Journal of Medical Primatology

      Volume: 41 Pages: 11-17

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] HCV 6a prevalence in guangdong province had the origin from Vietnam and recent dissemination to other regions of China2012

    • Author(s)
      Yongshui Fu, Weibing Qin, Hong Cao, Ru Xu, Yi Tan, Teng Lu, Hongren Wang, Wangxia Tong, Xia Rong, Gang Li, Manqiong Yuan, Chunhua Li, Kenji Abe, Ling Lu
    • Journal Title

      Phylogeographic analyses

      Volume: 7

    • Related Report
      2011 Final Research Report
  • [Journal Article] Systematic review : Epidemiology of hepatitis C genotype 6 and its management2011

    • Author(s)
      David T. Chao, Kenji Abe, Mindie H. Nguyen
    • Journal Title

      Alimentary Pharmacology & Therapeutics

      Volume: 34 Pages: 286-296

    • Related Report
      2011 Final Research Report
  • [Journal Article] Very high prevalence of hepatitis C virus genotype 6 variants in Southern Vietnam : Large-scale survey based on sequence determination2011

    • Author(s)
      Van H. Pham, Huyen D. P. Nguyen, Phat T. Ho, Dien V. Banh, Hoa L. T. Pham, Phiet H. Pham, Ling Lu, Kenji Abe
    • Journal Title

      Japanese Journal of Infectious Diseases

      Volume: 64 Pages: 537-539

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Hepatic progenitor cells in liver cancers from Asian children2010

    • Author(s)
      Stephen C. Ward, Swan N. Thung, Kiat Hon Lim, Tung Thanh Tran, Thi Khang Bui Hong, Phuc Le Hoang, Ja June Jang, Young Nyun Park, Kenji Abe
    • Journal Title

      Liver International

      Volume: 30 Pages: 102-111

    • Related Report
      2011 Final Research Report
  • [Journal Article] Presence of hepatitis C virus RNA by nested polymerase chain reaction in plasma-derived hepatitis B vaccine non-responders2010

    • Author(s)
      Moh Moh Htun, Khin Pyone Kyi, Khin May Oo, Myo Khin, Win Maw Tun, San San Oo, Khin Ohnmar Lwin, Kenji Abe
    • Journal Title

      Myanmar Health Sciences Research Journal

      Volume: 22 Pages: 101-104

    • Related Report
      2011 Final Research Report
  • [Journal Article] Hepatic progenitor cells in liver cancers from Asian children.2010

    • Author(s)
      Stephen C.Ward, et al.
    • Journal Title

      Liver International

      Volume: 30 Pages: 102-111

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Presence of hepatitis C virus RNA by nested polymerase chain reaction in plasma-derived hepatitis B vaccine non-responders.2010

    • Author(s)
      Moh Moh Htun, et al.
    • Journal Title

      Myanmar Health Sciences Research Journal

      Volume: 22 Pages: 101-104

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pre-S2 deletion mutants of hepatitis B virus could have an important role in hepatocarcinogenesis in Asian children2009

    • Author(s)
      Kenji Abe, Swan N. Thung, Han-Chieh Wu, Tung Thanh Tran, Phuc Le Hoang, Khai Dinh Truong, Ayano Inui, Ja June Jang, Ih-Jen Su
    • Journal Title

      Cancer Science

      Volume: 100 Pages: 2249-2254

    • NAID

      10027197722

    • Related Report
      2011 Final Research Report
  • [Journal Article] Review : Pathology of hepadna virus infection in humans and animals2009

    • Author(s)
      Kenji Abe
    • Journal Title

      Thai Journal of Veterinary Medicine

      Volume: 39 Pages: 453-455

    • Related Report
      2011 Final Research Report
  • [Journal Article] Pathology of hepadna virus infection in humans and animals2009

    • Author(s)
      Kenji Abe, et al.
    • Journal Title

      Thai Journal of Veterinary Medicine 39

      Pages: 453-455

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pre-S2 deletion mutants of hepatitis B virus could have an important role in hepatocarcinogenesis in Asian children2009

    • Author(s)
      Kenji Abe, et al.
    • Journal Title

      Cancer Science 100

      Pages: 2249-2254

    • NAID

      10027197722

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Hepatitis B and C in Asia2011

    • Author(s)
      Kenji Abe
    • Organizer
      National Conference of Vietnamese Association for Hepatology
    • Place of Presentation
      Dalat, Vietnam
    • Related Report
      2011 Final Research Report
  • [Presentation] Hepatitis B and C in Asia2011

    • Author(s)
      Kenji Abe
    • Organizer
      National Conference of Vietnamese Association for Hepatology
    • Place of Presentation
      ベトナム・ダラット市(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Hepatitis C in experimentally infected chimpanzees : comparison with hepatitis B2010

    • Author(s)
      Kenji Abe
    • Organizer
      4th Ditan International Conference on Infectious Diseases
    • Place of Presentation
      Beijing, China
    • Related Report
      2011 Final Research Report
  • [Presentation] Molecular-based epidemiology and pathology of hepatitis B virus infection2010

    • Author(s)
      Kenji Abe
    • Organizer
      The National Conference on Medical Molecular Biology and Biochemistry
    • Place of Presentation
      Hanoi, Vietnam
    • Related Report
      2011 Final Research Report
  • [Presentation] Invited lecture=Hepatitis C in experimentally infected chimpanzees comparison with hepatitis B.2010

    • Author(s)
      Kenji Abe
    • Organizer
      4th Ditan International Conference on Infectious Diseases
    • Place of Presentation
      中国・北京
    • Related Report
      2010 Annual Research Report
  • [Presentation] Invited lecture Molecular-based epidemiology and pathology of hepatitis B virus infection.2010

    • Author(s)
      Kenji Abe
    • Organizer
      The National Conference on Medical Molecular Biology and Biochemistry
    • Place of Presentation
      ベトナム・ハノイ
    • Related Report
      2010 Annual Research Report
  • [Presentation] Stem cell origin of liver cancers in Asian children2009

    • Author(s)
      Swan N. Thung, Tung Thanh Tran, Phuc Le Hoang, Ja June Jang, Young Nyun Park, Kenji Abe
    • Organizer
      United States and Canadian Academy of Pathology
    • Place of Presentation
      Boston, U. S. A
    • Related Report
      2011 Final Research Report
  • [Presentation] Invited lecture : Pathogenesis of hepatitis B virus infection and its related hepatocellular carcinoma2009

    • Author(s)
      Kenji Abe
    • Organizer
      The 7th Pathology Conference of Vietnam
    • Place of Presentation
      Ho Chi Minh City, Vietnam
    • Related Report
      2011 Final Research Report
  • [Presentation] Invited lecture : Pathology of hepadna virus infection in humans and animals2009

    • Author(s)
      Kenji Abe
    • Organizer
      The 4th Asian Society of Veterinary Pathologists(ASVP) Conference
    • Place of Presentation
      Bangkok, Thailand
    • Related Report
      2011 Final Research Report
  • [Presentation] Hot spot mutation of hepatitis B virus pre-S2 gene related to hepatocellular carcinoma in Asian children2009

    • Author(s)
      Kenji Abe, Swan N. Thung, Han-Chieh Wu, Tung Thanh Tran, Phuc Le Hoang, Ayano Inui, Ja June Jang, Ih-Jen Su
    • Organizer
      The Excellence in Pediatrics International Conference
    • Place of Presentation
      Italy
    • Related Report
      2011 Final Research Report
  • [Presentation] Pathogenesis of hepatitis B virus infection and its related hepatocellular carcinoma2009

    • Author(s)
      Kenji Abe
    • Organizer
      The 7th Pathology Conference of Vietnam
    • Place of Presentation
      ベトナム・ホーチミン市
    • Related Report
      2009 Annual Research Report
  • [Presentation] Pathology of hepadna virus infection in humans and animals2009

    • Author(s)
      Kenji Abe
    • Organizer
      The 4th Asian Society of Veterinary Pathologist Conference
    • Place of Presentation
      タイ・バンコク
    • Related Report
      2009 Annual Research Report
  • [Presentation] Hot spot mutation of hepatitis B virus pre-S2 gene related to hepatocellular carcinoma in Asian children2009

    • Author(s)
      Kenji Abe, et al.
    • Organizer
      The Excellence in Paediatrics International Conference
    • Place of Presentation
      イタリア・フィレンツェ
    • Related Report
      2009 Annual Research Report
  • [Book] Chapter 76 : Hepatitis B virus. In : Don Liu eds. Molecular detection of human viral pathogens2010

    • Author(s)
      Kenji Abe
    • Publisher
      CRC Press
    • Related Report
      2011 Final Research Report
  • [Book] Hepatitis B virus(In : Don Liu eds.)(Molecular detection of human viral pathogens.)2010

    • Author(s)
      Kenji Abe
    • Publisher
      Taylor & Francis CRC Press, Florida, U.S.A.
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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