| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
Molecular mechanism of hormone therapy resistance, especially in prostate cancer, was investigated. Interleukin(IL)-1beta showed tumor inhibitory effect in several prostate cancer cell lines including LNCap, while a previous report suggested possible involvement of IL-1beta in the resistance. Constitutive expression of these enzymes support tumor cell growth in castrated nude mice. Thus we concluded that these results suggested expression of androgenic enzymes may be involved in acquired resistant against hormone therapy in cancer.
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