| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
The immune system is a system of biological structures and processes within an organism that protects against disease. To function properly, an immune system detects and removes a wide variety of microorganisms invading into the body and cancer cells. However, an excessive immune reaction causes another types of disease. To avoid it, we have lymphocytes that suppress the immune reaction, one of which is called CD4^+CD25^+regulatory T cells(Treg). Treg also suppress anti-tumor immune reaction in cancer tissues, resulting in supporting the cancer growth and extension. Here, in order to make clear the molecular mechanisms of the immune suppression mediated by Treg, we found a new molecule expressed specifically in Treg and involved in the immune suppression, and characterized the molecule.
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