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Investigation of chromatin remodeling by histone modifier protein in carcinogenesis and progression.

Research Project

Project/Area Number 21590453
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionNational Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East

Principal Investigator

FUJII Satoshi  独立行政法人国立がん研究センター, 臨床開発センター, 室長 (30314743)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords腫瘍 / ヒストン / クロマチン / がん
Research Abstract

It is demonstrated that MEK-ERK1/2-Elk-1 pathway leads to EZH2 overexpression. The triple-negative and ERBB2-overexpressing subtypes of breast cancer are known to contain more rapidly proliferating breast cancer cells. The signaling pathway connected to EZH2 overexpression was associated with both aggressive subtypes of breast cancer, showing one of the clinicopathological significance of overexpression of histone modifier protein. The oncogenic role of EZH2, a histone modifier protein that is induced by oncogenic mutant RAS is also defined in pancreatic carcinogenesis, using pancreatic cancers of transgenic rats exogenously expressing human mutant RAS. That is, EZH2 was found to be a real effecter protein in the downstream of the MEK-ERK pathway in pancreatic carcinogenesis.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (17 results)

All 2012 2011 2010 2009

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (12 results) Book (1 results)

  • [Journal Article] RAS oncogenic signal upregulates EZH2 in pancre atic cancer2012

    • Author(s)
      Fujii S(他5名、1番目)
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 417 Issue: 3 Pages: 1074-79

    • DOI

      10.1016/j.bbrc.2011.12.099

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] MEK-ERK pathway regulates EZH2 overexpression in association with aggressive breast cancer subtypes2011

    • Author(s)
      Fujii S(他6名、1番目)
    • Journal Title

      Oncogene

      Volume: 30 Issue: 39 Pages: 4118-28

    • DOI

      10.1038/onc.2011.118

    • Related Report
      2011 Annual Research Report 2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant expression of EZH2 is associated with a poor outcome and P53 alteration in squamous cell carcinoma of the esophagus2011

    • Author(s)
      Yamada A、Fujii S(他5名、2番目)
    • Journal Title

      Int J Oncol

      Volume: 38 Issue: 2 Pages: 345-53

    • DOI

      10.3892/ijo.2010.868

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant expression of EZH2 is associated with a poor outcome and P53 alteration in squamous cell carcinoma of the esophagus2011

    • Author(s)
      Yamada A
    • Journal Title

      Int J Oncol

      Volume: 38 Pages: 345-353

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] The significance of histone variants in cancer cells.がん細胞におけるヒストン変異体の意義2011

    • Author(s)
      藤井誠志
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2011-10-03
    • Related Report
      2011 Final Research Report
  • [Presentation] The significance of histone variants in cancer cellsがん細胞におけるヒストン変異体の意義2011

    • Author(s)
      藤井誠志
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 高悪性度亜型の乳癌におけるヒストン修飾蛋白の高発現の意義2011

    • Author(s)
      藤井誠志
    • Organizer
      第19回日本乳癌学会学術総会
    • Place of Presentation
      仙台市
    • Year and Date
      2011-09-02
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] エストロゲンレセプター陽性乳癌におけるEZH2発現機構の解明2011

    • Author(s)
      小林真希
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-04-28
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] ヒストン修飾蛋白によるがんの発生及び進展機構の解明2010

    • Author(s)
      藤井誠志
    • Organizer
      第56回日本病理学会秋期特別総会学術研究賞演説(A演説)
    • Place of Presentation
      北九州市
    • Year and Date
      2010-11-26
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] MEK-ERK pathway regulates overexpression of EZH2, which is associated with aggressive breast cancer subtypes2010

    • Author(s)
      藤井誠志
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪市
    • Year and Date
      2010-09-22
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Ras変異体導入による腫瘍発生におけるヒストン修飾蛋白の関与2010

    • Author(s)
      藤井誠志
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京都
    • Year and Date
      2010-04-27
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 活性酸素種によるヒストン修飾蛋白の発現誘導2010

    • Author(s)
      小林真季
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京都
    • Year and Date
      2010-04-27
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] RAS変異体導入による腫瘍発生におけるヒストン修飾蛋白の関与2009

    • Author(s)
      藤井誠志
    • Organizer
      第20回日本消化器癌発生学会総会
    • Place of Presentation
      広島市
    • Year and Date
      2009-11-26
    • Related Report
      2011 Final Research Report
  • [Presentation] RAS変異体導入による腫瘍発生におけるヒストン修飾蛋白の関与2009

    • Author(s)
      藤井誠志
    • Organizer
      第20回日本消化器癌発生学会総会
    • Place of Presentation
      広島市 オリエンタルホテル
    • Year and Date
      2009-11-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] ERK pathway regulates the expression of histone modification protein in cancer cells2009

    • Author(s)
      藤井誠志
    • Organizer
      第68回日本癌学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2009-10-01
    • Related Report
      2011 Final Research Report
  • [Presentation] ERK pathway regulates the expression of histone modification protein in cancer cells2009

    • Author(s)
      藤井誠志
    • Organizer
      第68回日本癌学会総会
    • Place of Presentation
      横浜市 パシフィコ横浜
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Book] 腫瘍病理鑑別診断アトラス食道癌「扁平上皮癌の悪性度評価」2012

    • Author(s)
      藤井誠志
    • Publisher
      文光堂
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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