| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Invasive phenotype was induced by inhibition of VEGF signaling. Hypoxia inducible factor(HIF) is a transcription factor, which regulate hypoxic response. We generated double KO mice of HIF-1αand VEGF in islet cell tumor model mice. Invasive phenotype was remarkably reduced in DKO mice. Levels of E-cadherin expression was reduced in VEGF KO tumors but recovered in DKO mice. Thus, HIF is important for invasive phenotype after angiogenesis inhibition, and decreased E-cadherin levels might be a downstream mechanism.
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