| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Research Abstract |
In Trypanosoma cuzi infected cells, the production of reactive oxygen species including nitric oxide (NO) was increased and inducible nitric oxide synthase (iNOS) gene was up-regulated. The inhibition of apoptosis in infected cells was reduced by the addition of NOS inhibitors. Furthermore, cellular FLICE-like inhibitory protein (c-FLIP), an apoptosis inhibitory protein, was nitrosylated in T. cruzi infected cells.
|
