Regulation of oxidative stress and apoptosis in Trypanosoma cruzi infected cells
| Project/Area Number |
21590461
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Gunma University |
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Principal Investigator |
SHIMADA Junko 群馬大学, 大学院・保健学研究科, 教授 (20211964)
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| Co-Investigator(Kenkyū-buntansha) |
HATABU Toshimitsu 群馬大学, 大学院・保健学研究科, 助教 (60344917)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 感染症 / 応用微生物 / ストレス |
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| Research Abstract |
In Trypanosoma cuzi infected cells, the production of reactive oxygen species including nitric oxide (NO) was increased and inducible nitric oxide synthase (iNOS) gene was up-regulated. The inhibition of apoptosis in infected cells was reduced by the addition of NOS inhibitors. Furthermore, cellular FLICE-like inhibitory protein (c-FLIP), an apoptosis inhibitory protein, was nitrosylated in T. cruzi infected cells.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] The role of VAMP7/TI-VAMP in cell polarity and lysosomal exocytosis in vivo2011
Author(s)
Sato M, Yoshimura S, Hirai R, Goto A Kunii M, Atik N, Sato T, Sato K, Harada R, Shimada J, Hatabu T, Yorifuji H, Harada A
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Journal Title
Traffic
Volume: 12
Pages: 1383-1393
Related Report
Peer Reviewed
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