| Project/Area Number |
21590463
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Gifu University |
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Principal Investigator |
WU Zhiliang 岐阜大学, 医学系研究科, 助教 (90313874)
|
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| Co-Investigator(Kenkyū-buntansha) |
NAGANO Isao 岐阜大学, 大学院・医学系研究科, 准教授 (40283296)
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| Research Collaborator |
THIDRUT Boonmars タイコンケン大学, 医学部, 准教授
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | タイ肝吸虫 / 胆管癌 / 発癌 / 分子機構 / マイクロアレイ / 発癌メカニズム / 腫瘍マーカー / DNAメチル / Pdgfa / 遺伝子発現 / Rbシグナル経路 |
|---|
| Research Abstract |
In the present study, by using animal model of opisthorchiasis-associated cholangiocarcinoma(CCA) and the analysis of CCA tumor tissues of the patients from epidemic areas in Thailand, the genes and signaling pathways to involve in the tumorigenesis, and the biomarkers correlated with stage, metastasis and survival were identified. The study revealed the molecular mechanism that chronic inflammation caused by Opisthorchis viverrini infection decreases the ability of detoxination, leading to the accumulation of ROS and the toxin products from worm, which causes DNA damage, epigenesis and methylation, and expression change of the genes that promotes cell proliferation, differentiation, transformation and carcinogenesis.
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