Analyses and Evaluation of the effects of environmental factors on the outcome of leishmaniasis

• Project/Area Number: 21590465
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Parasitology (including Sanitary zoology)
• Research Institution: Nagasaki University
• Principal Investigator: HAMANO Shinjiro 長崎大学, 熱帯医学研究所, 教授 (70294915)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 原虫 / リーシュマニア症 / 蠕虫 / 免疫 / 栄養 / 蠕虫感染 / 免疫応答 / 体内環境因子 / 腸管内蠕虫感染 / 栄養不良 / カラ・アザール / 発症 / Heligmosomoides polvgylus / Leishmania donovani

Research Abstract

The purpose of this study was to identify and estimate the effects of environmental risk factors for the development to active leishmaniasis. We prepared mice with malnutrition and intestinal parasitism and monitored nutrient and immunological status. These mice were subcutaneously challenged with L. major and no significant difference among the groups of mice was observed. Further study will be carried out in Bangladesh, one of the endemic countries of leishmaniasis.

Research Products

• [Journal Article] A critical role for phagocytosis in resistance to malaria in iron-deficient mice (2011)
  • Author(s): Matsuzaki, C. M., Tu, L., Ishida, H., Imai, T., Suzue, K., Hirai, M., Tetsutani, K., Hamano, S., Shimokawa, C., Hisaeda, H.
  • Journal Title: Eur. J. Immunol Volume: 41(5) Pages: 1365-1375
• [Journal Article] Aberrant IL-4 production by SOCS3-overexpressing T cells during infection with Leishmania major exacerbates disease manifestations (2011)
  • Author(s): Nakaya, M., Hamano, S., Yoshida, H., Yoshimura, A., Kobayashi, T.
  • Journal Title: Int. Immunol Volume: 23(3) Pages: 195-202
• [Journal Article] アメーバ赤痢やクリプトスポリジウム症の現状と最新の知見 (2011)
  • Author(s): 原田倫世、濱野真二郎
  • Journal Title: 化学療法の領域 Volume: 27(4) Pages: 72-79
• [Journal Article] A critical role for phagocytosis in resistance to malaria in iron-deficient mice (2011)
  • Author(s): Matsuzaki, C.M., Tu, L., Ishida, H., Imai, T., Suzue, K., Hirai, M., Tetsutani, K., Hamano, S., Shimokawa, C, Hisaeda, H.
  • Journal Title: Eur.J.Immunol. Volume: 41 Issue: 5 Pages: 1365-75
  • DOI: 10.1002/eji.201040942
  • Peer Reviewed
• [Journal Article] Aberrant IL-4 production by SOCS3-overexpressing T cells during infection with Leishmania major exacerbates disease manifestations (2011)
  • Author(s): Nakaya, M., Hamano, S., Yoshida, H., Yoshimura, A., Kobayashi, T.
  • Journal Title: Int.Immunol. Volume: 23 Issue: 3 Pages: 195-202
  • DOI: 10.1093/intimm/dxq472
  • Peer Reviewed
• [Journal Article] Members of the Entamoeba histolytica transmembrane kinase family play non-redundant roles in growth and phagocytosis. (2010)
  • Author(s): Buss, S.N., Hamano, S., Vidrich, A., Evans, C., Zhang, Y., Crasta, O.R., Sobral, B.W., Gilchrist, C.A., Petri, W.A.Jr.
  • Journal Title: Int.J.Parasitol. Volume: 40 Pages: 833-843
  • Peer Reviewed
• [Journal Article] IL-17 is necessary for host protection against acute-phase Trypanosoma cruzi infection. (2010)
  • Author(s): Miyazaki, Y., Hamano, S., Wang, S., Shimanoe, Y., Iwakura, Y., Yoshida, H.
  • Journal Title: J.Immunol. Volume: 185 Pages: 1150-1157
  • Peer Reviewed
• [Journal Article] Involvement of CD8+ T cells in protective immunity against murine blood-stage infection with Plasmodium yoelii 17XL strain. (2010)
  • Author(s): Imai, T., Shen, J., Chou, B., Duan, X., Tu, L., Tetsutani, K., Moriya, C., Ishida, H., Hamano, S., Shimokawa, C., Hisaeda, H., Himeno, K.
  • Journal Title: Eur.J.Immunol. Volume: 40 Pages: 1053-1061
  • Peer Reviewed
• [Journal Article] Development of experimental cerebral malaria is independent of IL-23 and IL-17. (2010)
  • Author(s): Ishida, H., Matsuzaki-Moriya, C., Imai, T., Yanagisawa, K., Nojima, Y., Suzue, K., Hirai, M., Iwakura, Y., Yoshimura, A., Hamano, S., Shimokawa, C., Hisaeda, H.
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 402 Pages: 790-795
  • Peer Reviewed
• [Journal Article] 寄生虫感染と免疫応答 (2010)
  • Author(s): 濱野真二郎、吉田裕樹
  • Journal Title: 感染症 Volume: 40 Pages: 205-211
  • Peer Reviewed
• [Presentation] Schistosoma mansoni infection induces the unique T cell populations in the livers of mice (2012)
  • Author(s): Keishi Adachi, Shinjiro Hamano
  • Organizer: 第81回日本寄生虫学会総会
  • Place of Presentation: 兵庫医科大学西宮キャンパス
  • Year and Date: 2012-03-23
• [Presentation] Schistosoma mansoni infection induces the unique T cell populations in the livers of mice (2012)
  • Author(s): Keishi Adachi, Shinjiro Hamano
  • Organizer: 第81回日本寄生虫学会総会
  • Place of Presentation: 兵庫県兵庫医科大学
  • Year and Date: 2012-03-23
• [Presentation] Analysis of the unique immunological reactions in the liver after Schistosoma mansoni infection in mice (2011)
  • Author(s): Adachi, Shinjiro Hamano
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2011-11-27
• [Presentation] Analysis of the unique immunological reactions in the liver after Schistosoma mansoni infection in mice (2011)
  • Author(s): Keishi Adachi, Shinjiro Hamano
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 千葉県幕張メッセ
  • Year and Date: 2011-11-27
• [Presentation] フィールド・ラボ双方向からのアプローチ (2011)
  • Author(s): 濱野真二郎
  • Organizer: 第52回日本熱帯医学会
  • Place of Presentation: 東京大学
  • Year and Date: 2011-11-04
• [Presentation] マンソン住血吸虫感染時に肝臓内で誘導される免疫反応についての解析 (2011)
  • Author(s): 安達圭志、濱野真二郎
  • Organizer: 第5回蠕虫研究会
  • Place of Presentation: 青島サンクマール
  • Year and Date: 2011-07-29
• [Presentation] 熱帯感染症の克服を目指して～眠り病からのアプローチ (2011)
  • Author(s): 濱野真二郎
  • Organizer: 第48回日本アフリカ学会学術大会
  • Place of Presentation: 弘前大学
  • Year and Date: 2011-05-21
• [Presentation] シンポジウム『もし眠り病の特効薬ができたら-病気への学際的アプローチ-』、「熱帯感染症の克服を目指して～眠り病からのアプローチ」 (2011)
  • Author(s): 濱野真二郎
  • Organizer: 第48回日本アフリカ学会学術大会
  • Place of Presentation: 青森県弘前大学
  • Year and Date: 2011-05-21
• [Presentation] The effect of intestinal parasitism of nematode on the course of leishmaniasis. (2010)
  • Author(s): 濱野真二郎
  • Organizer: 第3回原虫感染免疫研究会
  • Place of Presentation: 長崎市、長崎大学熱帯医学研究所
  • Year and Date: 2010-03-27
• [Book] ジアルジア症、自由生活性アメーバ症、赤痢アメーバ症、感染症事典 (2012)
  • Author(s): 下川周子・濱野真二郎
  • Publisher: オーム社
• [Book] トキソプラズマ症、リーシュマニア症、アニサキス症、疥癬症、蟯虫症、日本海裂頭条虫症、感染症事典 (2012)
  • Author(s): 濱野真二郎
  • Publisher: オーム社
• [Book] 感染症事典 (2012)
  • Author(s): 感染症事典編集委員会編
  • Publisher: オーム社
• [Remarks] ホームページ等日本語
  • URL: http://www.tm.nagasaki-u.ac.jp/nekken/research/parasitology.html
• [Remarks] ホームページ等英語
  • URL: http://www.tm.nagasaki-u.ac.jp/nekken/english/research/parasitology.html