Studies on the infection mechanisms of Strongyloides venezelensis by analyzing genes expressed in infective larvae.
| Project/Area Number |
21590466
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 線虫 / トランスクリプトーム / 糞線虫 / メタロプロテアーゼ / 寄生虫 / 感染 / 熱帯病 / 体内移行 / 感染幼虫 / 宿主侵入 / 遺伝子発現 / 遺伝子ノックダウン / ゲノム |
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| Research Abstract |
Gene expression of infective larvae of Strongyloides venezuelensis, an intestinal nematode of rodents, was examined by means of conventional EST analysis and a large-scale sequencing with a next generation pyrosequencer. Nearly half of the genes which were expressed specifically in the infective larva stage coded novel proteins of unknown function, though several genes for astacin-like metalloprotease were detected. These zinc-metalloproteases could account for the skin invasion of infective larvae upon infection. Astacin-like metalloproteases appeared to form a large gene family, suggesting its importance in parsitism.
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Report
(4 results)
Research Products
(28 results)
