| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
Gene expression of infective larvae of Strongyloides venezuelensis, an intestinal nematode of rodents, was examined by means of conventional EST analysis and a large-scale sequencing with a next generation pyrosequencer. Nearly half of the genes which were expressed specifically in the infective larva stage coded novel proteins of unknown function, though several genes for astacin-like metalloprotease were detected. These zinc-metalloproteases could account for the skin invasion of infective larvae upon infection. Astacin-like metalloproteases appeared to form a large gene family, suggesting its importance in parsitism.
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