| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Chemotherapeutic effect of ascofuranone, a new antibiotic, was determined using Cryptosporidium parvum-infected SCID mice. The drug was administrated to infected mice by oral, intraperitoneal, and intravenous route. A suspension of ascofuranone(100mg/kg) was given every 24 h for 6 consecutive days to infected mice and efficacy was evaluated by oocysts reduction in the feces of treated mice by fluorescent microscopically. Oocysts in the feces were over 2 x 10^5/g at the beginning of oral administration, the numbers of oocysts were gradually decreased to 8 x 10^3/g on day 6.After stopping the treatment, numbers of oocysts were increased to over 4 x 10^5/g on day 10.Almost same results were observed in intraperitoneally and intravenously administrations.
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