| Project/Area Number |
21590470
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ISHIWATA Kenji 東京慈恵会医科大学, 医学部, 准教授 (00241307)
|
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| Co-Investigator(Renkei-kenkyūsha) |
KARASUYAMA Hajime 東京医科歯科大学, 医歯学総合研究科, 教授 (60195013)
FURUTA Takahisa 東京大学, 医科学研究所, 助教 (30143514)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 寄生虫 / マスト細胞 / 好塩基球 / 感染防御 / マラリア / ダニ / デングウイルス / VEGF / IgE / 旋毛虫 / キマーゼ / 寄生虫感染 / マラアリア |
|---|
| Research Abstract |
This study demonstrates that mast cells and basophils play major roles in protection and pathogenesis of parasite infections in humans and mice. Mast cells participate in the protection to Plasmodium through TNF and VEGF, and are pathogenic factor in severe Dengue virus infection. Basophils are essential for IgE mediated-acquired immunity to ticks.
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