| Project/Area Number |
21590471
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Aichi Medical University |
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Principal Investigator |
KIMURA Eisaku 愛知医科大学, 医学部, 教授 (70153187)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAGI Hidekazu 愛知医科大学, 医学部, 講師 (90288522)
KADOSAKA Teruki 愛知医科大学, 医学部, 講師 (90109760)
ITOH Makoto 愛知医科大学, 医学部, 教授 (90137117)
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| Research Collaborator |
SHINTOKU Yoshimi 愛知医科大学, 医学部, 研究員
KONDO Shigeo 愛知医科大学, 医学部, 教学監
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 蠕虫 / ネズミ糞線虫 / 大腸寄生 / 自食作用 / 遺伝子解析 |
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| Research Abstract |
Strongyloides ratti parasitizes the small intestine of a rat for 2-3 weeks and then is expelled quickly by host immunity. However, some adults tolerate the expulsion, and around 20 days after infection, start parasitizing the large intestine. The large intestinal parasitism is considered as their survival strategy, which is triggered by otherwise harmful host immunity. We have obtained genes that are expressed more in large intestinal adults, and the functions of such genes are under investigation with RNA interference.
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