| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
Inflammatory diseases, such as Rheumatoid Arthritis or infection induced septic shock decline patient's quality of life along with the progression of the diseases. To prevent the progression of diseases, rapid and precise diagnosis becomes an important matter. However, complex immune networks, mainly controlled with cytokines, obstruct proper understandings of those inflammatory diseases. In this study, I introduced newly developed flowcytometry-based suspension-array system which simultaneously measures 20-30 kind of target cytokines and proteins. Using this method, I clearly demonstrated that the abrogation of CD4+CD25+regulatory T cell function via glucocorticoid-induced TNF receptor(GITR) were major immune modulators those induced excess productions of various kinds of cytokine and deterioration of inflammatory diseases.
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