| Project/Area Number |
21590474
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUO Junji 北海道大学, 大学院・保健科学研究院, 助教 (50359486)
KAMIYA Shigeru 杏林大学, 医学部, 教授 (10177587)
NAKAMURA Shinji 順天堂大学, 医学研究科, 助教 (40207882)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | Chlamydophila pneumoniae / リンパ球細胞 / IFNγ / 付着 / ヘパリン / グランザイムK / 肺炎クラミジア / グランザイム / エフェクター蛋白 / 外膜蛋白 / ストレス蛋白GroEL1 / 持続感染 |
|---|
| Research Abstract |
We assessed pathogenic chlamydial infection mechanism to lymphocytes when compared to epithelial cells. As a result, we found the unique chlamydial attachment process on lymphocytes, independent of heparin, which has a critical on bacterial general attachment to cells. It was also confirmed by using DNA microarray that pathogenic chlamydial survival in lymphocytes was controlled by granzyme K. Furthermore, we demonstrated that lymphocytes could provide a shelter for pathogenic chlamydiae to escape from IFNγ. Thus, pathogenic chlamydial infection mechanism to lymphocytes is unique when compared to epithelial cells, possibly connecting clinical significance.
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