Molecular mechanism of pathogenic chlamydial infection to lymphocytes
| Project/Area Number |
21590474
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUO Junji 北海道大学, 大学院・保健科学研究院, 助教 (50359486)
KAMIYA Shigeru 杏林大学, 医学部, 教授 (10177587)
NAKAMURA Shinji 順天堂大学, 医学研究科, 助教 (40207882)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | Chlamydophila pneumoniae / リンパ球細胞 / IFNγ / 付着 / ヘパリン / グランザイムK / 肺炎クラミジア / グランザイム / エフェクター蛋白 / 外膜蛋白 / ストレス蛋白GroEL1 / 持続感染 |
|---|
| Research Abstract |
We assessed pathogenic chlamydial infection mechanism to lymphocytes when compared to epithelial cells. As a result, we found the unique chlamydial attachment process on lymphocytes, independent of heparin, which has a critical on bacterial general attachment to cells. It was also confirmed by using DNA microarray that pathogenic chlamydial survival in lymphocytes was controlled by granzyme K. Furthermore, we demonstrated that lymphocytes could provide a shelter for pathogenic chlamydiae to escape from IFNγ. Thus, pathogenic chlamydial infection mechanism to lymphocytes is unique when compared to epithelial cells, possibly connecting clinical significance.
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Report
(4 results)
Research Products
(100 results)
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[Journal Article] Ciliates expel environmental Legionella-laden pellets for stockpiling food2012
Author(s)
Hojo F, Sato D, Matsuo J, Miyake M, Nakamura S, Kunichika M, Hayashi Y, Yoshida M, Takahashi K, Takemura H, Kamiya S, Yamaguchi H
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Journal Title
Applied Environmental Microbiology
Volume: (in press)
NAID
Related Report
Peer Reviewed
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[Journal Article] Chlamydia trachomatis serovar L2 infection model using human lymphoid Jurkat cells2012
Author(s)
Kubo T, Ishida K, Matsuo J, Nakamura S, Hayashi Y, Sakai H, Yoshida M, Takahashi K, Hirai I, Yamamoto Y, Yamaguchi H
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Journal Title
Microbial Pathogenesis
Volume: (in press)
NAID
Related Report
Peer Reviewed
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[Journal Article] Chlamydophila pneumoniae attachment and infection in low proteoglycan expressing human lymphoid Jurkat cells2011
Author(s)
Kobayashi M, Ishida K, Matsuo J, Nakamura S, Nagasawa A, Motohashi1 K, Yao T, Hirai I, Yamamoto Y, Suzuki H, Shimizu C, Matsuno K, Yamaguchi H
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Journal Title
Microbial Pathogenesis
Volume: 51
Pages: 209-216
NAID
Related Report
Peer Reviewed
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[Journal Article] Ciliates promote the transfer of the gene encoding the extended-spectrum beta-lactamase CTX-M-27 between Escherichia coli strains2011
Author(s)
Oguri S, Matsuo J, Hayashi Y, Nakamura S, Hanawa T, Fukumoto T, Mizutani Y, YaoT, Akizawa K, Suzuki H, Shimizu C, Matsuno K, Kamiya S, Yamaguchi H
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Journal Title
Journal of Antimicrobial Chemotherapy
Volume: 66
Pages: 527-530
Related Report
Peer Reviewed
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[Journal Article] Ciliates rapidly enhance frequency of conjugation between Escherichia coli strains through bacterial accumulation in vesicles2010
Author(s)
Matsuo J, Oguri S, Nakamura S, Hanawa T, Fukumoto T, Hayashi Y, Kawaguchi K, Mizutani Y, Yao T, Akizawa K, Suzuki H, Simizu C, Matsunoa K, Kamiya S, Yamaguchi H
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Journal Title
Research in Microbiology
Volume: 161
Pages: 711-719
NAID
Related Report
Peer Reviewed
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[Journal Article] Impact of free-living amoebae on presence of Parachlamydia acanthamoebae in the hospital environment and its survival in vitro without requirement for amoebae2010
Author(s)
Fukumoto T, Matsuo J, Hayashi Y, Oguri S, Nakamura S, Mizutani Y, Yao T, Akizawa K, Suzuki H, Shimizu C, Matsuno K, Yamaguchi H
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Journal Title
Journal of Clinical Microbiology
Volume: 48
Pages: 3360-3365
NAID
Related Report
Peer Reviewed
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