Analysis of antibiotics resistance and virulence of multidrug resistant S. maltophilia

Research Project

Project/Area Number	21590477
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Bacteriology (including Mycology)
Research Institution	Gunma University
Principal Investigator	TANIMOTO Kouichi 群馬大学, 大学院・医学系研究科, 准教授 (40188389)
Project Period (FY)	2009 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000) Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	Stenitrophomonas maltophilia / 薬剤耐性 / 病原性因子 / PFGE / MLST / S. maltophilia / 臨床分離株 / 病原因子 / 遺伝子 / 感染症 / 抗生物質 / 細菌
Research Abstract	The diversity within the genetic and antibiotic resistance profiles and the production of virulence-associated enzymatic activities of 66 Stenotrophomonas maltophilia strains collected from a university hospital were studied. PFGE and MLST analysis indicated that there were a variety of profiles present. The study of virulence factors indicated that these strains did not have strong virulence factors. Those results suggested that clinical isolates studied were community-acquired strains and stayed in a hospital because of their multiple drug resistances.