| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
Protein Ser/ Thr Kinase(K)-Phosphatase(P) plays essential roles in regulation of cellular functions in both prokaryotes and eukaryotes. Although Clostridia have also the K-P systems, they have not been investigated. In this study, we revealed function of the K-P system in C. perfringens by analyzing in-frame deletion mutants of the system and the target protein(S) for K identified. Our results indicate that the K-P system regulates morphology of Clostridia via phosphorylation of S.
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