| Project/Area Number |
21590484
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | University of the Ryukyus |
|---|
Principal Investigator |
TOMA Claudia 琉球大学, 医学研究科, 助教 (40325832)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Toshihiko 琉球大学, 医学研究科, 教授 (10292848)
|
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| Co-Investigator(Renkei-kenkyūsha) |
KOIZUMI Nobuo 国立感染症研究所, 医学系, 主任研究官 (10333361)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
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| Keywords | 病原性 / 細菌 / 感染症 / マクロファージ |
|---|
| Research Abstract |
We examined in this study the mechanism of macrophage infection by pathogenic Leptospira. Pathogenic leptospires were found within phagosomes. However, acquisition of lysosomal markers lagged behind that of non-pathogenic leptospires-containing phagosomes. In macrophages infected with pathogenic leptospires, intact leptospires were found within vacuoles at 24 hours post infection, while non-pathogenic leptospires were degraded. Furthermore, a population of pathogenic leptospires was released to the extracellular milieu.
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