Strategy used to infect macrophages by the zoonotic bacteria Leptospira
| Project/Area Number |
21590484
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
TOMA Claudia 琉球大学, 医学研究科, 助教 (40325832)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Toshihiko 琉球大学, 医学研究科, 教授 (10292848)
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| Co-Investigator(Renkei-kenkyūsha) |
KOIZUMI Nobuo 国立感染症研究所, 医学系, 主任研究官 (10333361)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 病原性 / 細菌 / 感染症 / マクロファージ |
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| Research Abstract |
We examined in this study the mechanism of macrophage infection by pathogenic Leptospira. Pathogenic leptospires were found within phagosomes. However, acquisition of lysosomal markers lagged behind that of non-pathogenic leptospires-containing phagosomes. In macrophages infected with pathogenic leptospires, intact leptospires were found within vacuoles at 24 hours post infection, while non-pathogenic leptospires were degraded. Furthermore, a population of pathogenic leptospires was released to the extracellular milieu.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Pathogenic Vibrio activate NLRP3 inflammasome via cytotoxins and TLR/nucleotide-binding oligomerization domain-mediated NF-κB signaling2010
Author(s)
Toma C, Higa N, Koizumi Y, Nakasone N, Ogura Y, McCoy AJ, Franchi L, Uematsu S, Sagara J, Taniguchi S, Tsutsui H, Akira S, Tschopp J, Nunez G, Suzuki T.
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Journal Title
J. Immunol
Volume: 184
Pages: 5287-5297
Related Report
Peer Reviewed
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