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Genetic analysis of horizontal gene transfer of cyto lethal distending toxin(cdt) gene in Shigella spp. and Escherichia coli

Research Project

Project/Area Number 21590487
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Bacteriology (including Mycology)
Research InstitutionOsaka Prefecture University

Principal Investigator

YAMASAKI Shinji  大阪府立大学, 大学院・生命環境科学研究科, 教授 (70221653)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords赤痢菌 / 大腸菌 / 細菌毒素 / 水平伝播 / バクテリオファージ / 細胞膨化致死毒素 / 大陽菌
Research Abstract

There are five variants of Escherichia coli cytolethal distending toxin(Ec-cdtI-V) genes and a cdt(Sh-cdt) genes in Shigella spp. Ec-cdtI, Ec-cdtIV and Sh-cdt genes are located on lambdoid phages while Ec-cdtV genes are surrounded by genes related to P2 and lambdoid phages. Ec-cdtIII genes are located on plasmid, however, no genes was found, which are related to horizontal gene transfer, in the upstream and downstream regions of Ec-cdtII.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (38 results)

All 2012 2011 2010 2009 Other

All Journal Article (8 results) (of which Peer Reviewed: 4 results) Presentation (20 results) Remarks (10 results)

  • [Journal Article] Molecular characterization of cytolethal distending toxin produced by Providencia alcalifaciens isolated from patients with diarrhea2012

    • Author(s)
      A. Shima, A. Hinenoya, M. Asakura, N. Sugimoto, T. Tsukamoto, H. Ito, A. Nagita, S. M. Faruque, and S. Yamasaki
    • Journal Title

      Infect. Immun.

      Volume: 80 Pages: 1323-1332

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] エンテロトキシン・ベロ毒素2011

    • Author(s)
      山崎伸二
    • Journal Title

      家畜診療

      Volume: 58 Pages: 323-330

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Distribution of virulence genes related to adhesins and toxins in Shiga toxin-producing Escherichia coli strains isolated from healthy cattle and diarrheal patients in Japan2010

    • Author(s)
      Y. Wu, T. Taguchi, A. Nagita, A. Hinenoya, K. Shima, T. Tsukamoto, N. Sugimoto, M. Asakura, and S. Yamasaki
    • Journal Title

      J. Vet. Med. Sci.

      Volume: 72 Pages: 589-597

    • Related Report
      2011 Final Research Report
  • [Journal Article] 志賀毒素産生性大腸菌とその毒素2010

    • Author(s)
      山崎伸二
    • Journal Title

      食品衛生研究

      Volume: 60 Pages: 17-25

    • Related Report
      2011 Final Research Report
  • [Journal Article] Distribution of virulence genes related to adhesins and toxins in Shiga toxin-producing Escherichia coli strains isolated from healthy cattle and diarrheal patients in Japan2010

    • Author(s)
      Y.Wu, 他8名
    • Journal Title

      J.Vet.Med.Sci. 72

      Pages: 589-597

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2010

    • Author(s)
      山崎伸二
    • Journal Title

      食品衛生研究「志賀毒素産生性大腸菌とその毒素」(社団法人 日本食品衛生協会)

      Pages: 17-25

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Prevalence and characteristics of cytolethal distending toxin(Cdt)-producing Escherichia coli from children with diarrhea in Japan2009

    • Author(s)
      A. Hinenoya, A. Nagita, K. Ninomiya, M. Asakura, K. Shima, K. Seto, T. Tsukamoto, T. Ramamurthy S. M. Faruque, and S. Yamasaki
    • Journal Title

      Microbiol. Immunol

      Volume: 53 Pages: 206-215

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence and characteristics of cytolethal distending toxin (Cdt)-producing Escherichia coli from children with diarrhea in Japan2009

    • Author(s)
      A.Hinenoya, 他9名
    • Journal Title

      Microbiol.Immunol. 53

      Pages: 206-215

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Genetic analysis of cytolethal distending toxin genes in various Shigella species2012

    • Author(s)
      日根野谷淳、島綾香、朝倉昌博、山崎伸二
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎
    • Year and Date
      2012-03-27
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 市販牛肉における志賀毒素産生性大腸菌の汚染状況2011

    • Author(s)
      日根野谷淳、島綾香、向澤奈津子、丹羽裕子、四良丸幸、西川明芳、朝倉昌博、山崎伸二
    • Organizer
      第152回日本獣医学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2011-09-20
    • Related Report
      2011 Final Research Report
  • [Presentation] 市販牛肉における志賀毒素産生性大腸菌及びカンピロバクターの汚染状況2011

    • Author(s)
      日根野谷淳、島綾香、向澤奈津子、丹羽裕子、四良丸幸、西川明芳、朝倉昌博、山崎伸二
    • Organizer
      第15回腸管出血性大腸菌感染症研究会
    • Place of Presentation
      大阪
    • Year and Date
      2011-07-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Prevalence and characterization of cytolethal distending toxin-producing Escherichia coli in diarrheal and healthy children in Japan. International Union of Microbiological Societies 2011 Congress2011

    • Author(s)
      A. Shima, A. Hinenoya, M. Asakura, S. Shiramaru, T. Tsukamoto, and S. Yamasaki
    • Organizer
      XIII International Congress of Bacteriology and Applied Microbiology
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2011-06-10
    • Related Report
      2011 Final Research Report
  • [Presentation] Controlled study targeting cytotoxic necrotizing factor-producing Escherichia coli in Japan2011

    • Author(s)
      A. Hinenoya, N. Mukaizawa, A. Shima, M. Asakura, A. Nagita, and S. Yamasaki
    • Organizer
      International Union of Microbiological Societies 2011 Congress. XIII International Congress of Bacteriology and Applied Microbiology
    • Place of Presentation
      Sapporo, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Cytolethal distending toxin produced by Providencia alcalifaciens isolated from diarrheal patient in Japan2011

    • Author(s)
      A. Shima, A. Hinenoya, M. Asakura, N. Sugimoto, T. Tsukamoto, A. Nagita, and S. Yamasaki
    • Organizer
      European Workshop on Bacterial Protein Toxins(ETOX15)
    • Place of Presentation
      Oslo, Norway
    • Related Report
      2011 Final Research Report
  • [Presentation] 細胞壊死因子産生性大腸菌と小児下痢症との関係2010

    • Author(s)
      向澤奈津子, 島綾香, 日根野谷淳, 朝倉昌博, 名木田章, 山崎伸二
    • Organizer
      第63回日本細菌学会関西支部総会
    • Place of Presentation
      枚方
    • Year and Date
      2010-11-20
    • Related Report
      2011 Final Research Report
  • [Presentation] 細胞壊死因子産生性大腸菌と小児下痢症との関係2010

    • Author(s)
      向澤奈津子, 他5名
    • Organizer
      第63回 日本細菌学会関西支部総会
    • Place of Presentation
      枚方(大阪)
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Prevalence of cytolethal distending toxin-producing Escherichia coli in children in Japan2010

    • Author(s)
      島綾香、日根野谷淳、四良丸幸、朝倉昌博、山崎伸二
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2010-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] Chimeric cytolethal distending toxin(cdt) genes between cdt-I and cdt-IV in Escherichia coli2010

    • Author(s)
      日根野谷淳、朝倉昌博、杉本典彦、山崎伸二
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2010-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] 小児下痢症と細胞壊死因子(CNF)産生性大腸菌2010

    • Author(s)
      向澤奈津子、名木田章、島綾香、日根野谷淳、塚本定三、朝倉昌博、山崎伸二
    • Organizer
      第6回小児消化管感染症研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-02-06
    • Related Report
      2011 Final Research Report
  • [Presentation] ヒト及びウシから分離した志賀毒素産生性大腸菌における病原因子の保有状況の解析2010

    • Author(s)
      日根野谷淳、呉育羅、田口堯、朝倉昌博、杉本典彦、山崎伸二
    • Organizer
      第14回腸管出血性大腸菌感染症研究会
    • Place of Presentation
      宮崎
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Chimeric cytolethal distending toxin(cdt-I/cdt-IV) genes in Escherichia coli.2010

    • Author(s)
      A. Hinenoya, M. Asakura, N. Chowdhury, N. Sugimoto, S. M. Faruque and S. Yamasak
    • Organizer
      One hundred tenth of General Meeting of American Society for Microbiology
    • Place of Presentation
      SanDiego, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Ckimeric Cytolethal Distending Toxin (cdt-I/cdt-IV) genes in Escherichia coli.2010

    • Author(s)
      A.Hinenoya, 他5名
    • Organizer
      One hundred tenth of General Meeting of American Society for Microbiology
    • Place of Presentation
      SanDiego, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Chimeric cytolethal distending toxin(cdt) genes between cdt-I and cdt-IV in Escherichia coli2010

    • Author(s)
      日根野谷淳, 他3名
    • Organizer
      第83回 日本細菌学会総会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] prevaience of cytolethal distending toxin-producing Escherichia coli in children in Japan2010

    • Author(s)
      島綾香, 他4名
    • Organizer
      第83回 日本細菌学会総会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] 下痢症患者から分離したProvidencia alcalifaciensが産生する細胞膨化致死毒素の性状2009

    • Author(s)
      島綾香、日根野谷淳、杉本典彦、朝倉昌博、山崎伸二
    • Organizer
      第62回日本細菌学会関西支部総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-11-14
    • Related Report
      2011 Final Research Report
  • [Presentation] Providencia alcalifaciensが産生するCytolethal distending toxin(CDT)の性状解析2009

    • Author(s)
      島綾香、日根野谷淳、杉本典彦、朝倉昌博、山崎伸二
    • Organizer
      第56回毒素シンポジウム
    • Place of Presentation
      岐阜
    • Year and Date
      2009-08-26
    • Related Report
      2011 Final Research Report
  • [Presentation] Cytolethal distending toxin : a novel virulence factor produced by Providencia alcalifaciens isolated from diarrheal patients2009

    • Author(s)
      A. Shima, A. Hinenoya, M. Asakura, N. Sugimoto, T. Tsukamoto, A. Nagita, S. M. Faruque, S. Yamasaki
    • Organizer
      44th Joint Conference on cholera and other bacterial enteric infections panel
    • Place of Presentation
      San Diego, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Providencia alcalifaciens isolated from diarrheal patient produces cytolethal distending toxin2009

    • Author(s)
      A. Shima, A. Hinenoya, M. Asakura, N. Sugimoto, T. Tsukamoto, A. Nagita, and S. Yamasaki
    • Organizer
      One hundred ninth of General Meeting of American Society for Microbiology
    • Place of Presentation
      Pennsylvania, USA
    • Related Report
      2011 Final Research Report
  • [Remarks] 講演1山崎伸二:大阪病院機能向上研究会「腸管出血性大腸(EHEC)集団感染.ドイツO104.」2012年3月10日大阪

    • Related Report
      2011 Final Research Report
  • [Remarks] 2.山崎伸二:第37回日本食品微生物学会学術セミナー「生食用食肉等における規制制定とその後の問題」2012年3月2日和歌山

    • Related Report
      2011 Final Research Report
  • [Remarks] 3.山崎伸二:第3回日本旅行医学会関西セミナー「腸管出血性大腸菌O157、O104の病原性メカニズムとその対策」2012年2月18日大阪

    • Related Report
      2011 Final Research Report
  • [Remarks] 4.山崎伸二: 2012年衛生科学研究会冬季勉強会「ユッケ食中毒で話題となった腸管出血性大腸菌感染症の特徴」2012年2月10日吹田

    • Related Report
      2011 Final Research Report
  • [Remarks] 5.山崎伸二:大阪市環境食品技術者会特別講演会「生食肉による話題の食中毒.腸管出血性大腸菌感染症とその対策.」2011年11月18日大阪

    • Related Report
      2011 Final Research Report
  • [Remarks] 6.山崎伸二:第15回腸管出血性大腸菌感染症研究会緊急報告「ドイツでのO104 : H4による集団食中毒事例について」、2011年7月15日、大阪

    • Related Report
      2011 Final Research Report
  • [Remarks] 7.山崎伸二:社団法人日本食品衛生協会主催食品衛生特別講演会、食肉の生食にひそむ危険.腸管出血性大腸菌食中毒とその対応.「腸管出血性大腸菌食中毒・感染症の特徴と動向」、2011年6月30日、京都商工会議所、京都

    • Related Report
      2011 Final Research Report
  • [Remarks] 8.山崎伸二:第18回大阪府立母子保健総合医療センターシンポジウム「CDT産生性大腸菌は下痢の原因となりうるか?」2011年2月14日、大阪、和泉市

    • Related Report
      2011 Final Research Report
  • [Remarks] 9.山崎伸二:独立行政法人国立病院機構大阪南医療センター講演会、「腸内細菌研究の最近の話題」、2010年3月5日、河内長野、大阪

    • Related Report
      2011 Final Research Report
  • [Remarks] 10.S. Yamasaki. Prevalence of campylobacters and cytolethal distending toxin-producing Escherichia coli in diarrheal children in Japan. June 21st 2009, Guangzhou, China

    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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