| Project/Area Number |
21590488
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIMOMURA Hirofumi 自治医科大学, 医学部, 講師 (80348002)
YANO Tomonori 自治医科大学, 医学部, 助教 (30438634)
HAYASHI Shunji 自治医科大学, 医学部, 准教授 (40260765)
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| Research Collaborator |
HAYASHI Yoshikazu 自治医科大学, 附属病院, 病院助教
TAKEZAWA Takahito 自治医科大学, 附属病院, 臨床助教(レジデント)
HOSODA Kouich 自治医科大学, 医学部・大学院, 博士
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 構造 / 生理 / 細菌叢 / 小腸 / 胃 / 消化管 / ピロリ菌 / ナイセリア / ニトロソ化合物 / ダブルバルーン内視鏡 / ディフィシル菌 / 細菌 / 消化器 |
|---|
| Research Abstract |
The state of bacterial flora in the small intestine is unclear because of the difficulty for taking samples. We investigated bacteria quantitatively by cultures from small intestinal juices which were taken with a double-balloon endoscopeas a new technique. A few of bacteria were found in the stomach and duodenum, while we detected many bacteria on and after the lower jejunum. In the lower jejunum, anaerobic condition is established. Clostridium difficile was detected from approximately 60% of healthy adults. A half of isolated strains had enterotoxin genes(toxA and toxB). This bacterium was isolated on and after the ileum. In adults infected with Helicobacter pylori, the bacterium was culturable with juices from the stomach to the jejunum.
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