| Project/Area Number |
21590493
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
|
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| Research Institution | Juntendo University |
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Principal Investigator |
ITO Teruyo 順天堂大学, 医学部, 先任准教授 (10095763)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | MRSA / PVL / 遺伝子 / 病原性 / ラテックス凝集反応 / Cell / 市中感染型MRSA |
|---|
| Research Abstract |
The majority of MRSA strains isolated from outpatients of dermatology carried types IV or V SCCmec elements, which are characteristic in community-acquired MRSA strains. PVL positive isolates were roughly classified into two, the international clones that might be imported from other countries, e. g., US, India, or Taiwan, and the domestic clones.
Two novel PVL phages belonging to group 3 siphoviridae were identified in two international clones, ST59 and ST772. Titers of anti-PVL as well as anti-staphylococcus aureus antibodies in the sera of children were lower than those of adults, suggesting that it might be a reason that life-threatening infection was occurred among children.
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