Spread and pathogenecity of PVL-positive MRSA strains emerging in the community
| Project/Area Number |
21590493
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Juntendo University |
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Principal Investigator |
ITO Teruyo 順天堂大学, 医学部, 先任准教授 (10095763)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | MRSA / PVL / 遺伝子 / 病原性 / ラテックス凝集反応 / Cell / 市中感染型MRSA |
|---|
| Research Abstract |
The majority of MRSA strains isolated from outpatients of dermatology carried types IV or V SCCmec elements, which are characteristic in community-acquired MRSA strains. PVL positive isolates were roughly classified into two, the international clones that might be imported from other countries, e. g., US, India, or Taiwan, and the domestic clones.
Two novel PVL phages belonging to group 3 siphoviridae were identified in two international clones, ST59 and ST772. Titers of anti-PVL as well as anti-staphylococcus aureus antibodies in the sera of children were lower than those of adults, suggesting that it might be a reason that life-threatening infection was occurred among children.
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Report
(4 results)
Research Products
(54 results)
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[Journal Article] Trial to control an outbreak of Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus at a boarding school in Japan2011
Author(s)
Higashiyama M, Ito T, Han X, Nishiyama J, Tanno A, Wada T, Funaoka Y, Yoshida Y, Mikita K, Ogawa T, Okusa Y, Kaku K, Hatada J, Hiramatsu K, Kawana A.
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Journal Title
Am J Infect Control
Volume: 39(10)
Pages: 858-65
Related Report
Peer Reviewed
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[Journal Article] Heterogeneously vancomycin-intermediate Staphylococcus aureus(hVISA) emerged before the clinical introduction of vancomycin in Japan : a retrospective study2011
Author(s)
Yamakawa J, Aminaka M, Okuzumi K, Kobayashi H, Katayama Y, Kondo S, Nakamura A, Oguri T, Hori S, Cui L, Ito T, Jin J, Kurosawa H, Kaneko K, Hiramatsu K.
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Journal Title
NAID
Related Report
Peer Reviewed
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[Journal Article] Transcription and translation products of the cytolysin gene psm-mec on the mobile genetic element SCCmec regulate Staphylococcus aureus virulence2011
Author(s)
Kaito C, Saito Y, Nagano G, Ikuo M, Omae Y, Hanada Y, Han X, Kuwahara-Arai K, Hishinuma T, Baba T, Ito T, Hiramatsu K, Sekimizu K.
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Related Report
Peer Reviewed
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[Journal Article] Transcription and translation products of the cytolysin gene psm-mec on the mobile genetic element SCCmec regulate Staphylococcus aureus virulence.2011
Author(s)
Kaito C, Saito Y, Nagano G, Ikuo M, Omae Y, Hanada Y, Han X, Kuwahara-Arai K, Hishinuma T, Baba T, Ito T, Hiramatsu K, Sekimizu K.
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Related Report
Peer Reviewed
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[Journal Article] A report for controlling the dissemination of Panton-Valentine leukocidin-positive Methicillin-Resistant Staphylococcus aureus clone at a Boarding School in Japan2011
Author(s)
Masaaki Higashiyama, Teruyo Ito, Xiao Han, Akemi Tanno, Toshiko Wada, Youichi Funaoka, Yusuke Yoshida, Kei Mikita, Tomomichi Ogawa, Junichiro Nishiyama, Yasushi Okusa, Koki Kaku, Junichi Hatada, Keiichi Hiramatsu, Akihiko Kawana
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Journal Title
American Journal of Infection control
Volume: (In press)
Related Report
Peer Reviewed
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[Journal Article] Epidural abscess caused by community-associated methicillin-resistant Staphylococcus aureus strain USA300 in Japan2010
Author(s)
Higashiyama M, Ito T, Han X, Ono K, Minamimura K, Sakakibara F, Tanno A, Nishiyama J, Hatada J, Hiramatsu K, Kawana A.
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Journal Title
J Infect Chemother
Volume: 16(5)
Pages: 345-9
NAID
Related Report
Peer Reviewed
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[Journal Article] Identification of a novel variant of SCCmec, type-II. 5, and its truncated form by the insertion of putative conjugative transposon Tn60122009
Author(s)
Han X, Ito T, Takeuchi F, Ma XX, Takasu M, Uehara Y, Oliveira DC, de Lencastre H, Hiramatsu K.
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Journal Title
Antimicrob Agents Chemother
Related Report
Peer Reviewed
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