Epitope of causative microorganism of primary biliary cirrhosis

• Project/Area Number: 21590494
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Bacteriology (including Mycology)
• Research Institution: Juntendo University
• Principal Investigator: KIKUCHI Ken 順天堂大学, 医学部, 准教授 (60214748)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 原発性胆汁性肝硬変 / 抗原エピトープ / ヒストン様タンパク / Streptococcus intermedius / 比較ゲノム解析 / 分子模倣 / 原発性胆汁性肝硬変(PBC) / microcompartment / Strptococcus intermedius / histone-like protein / gp210

Research Abstract

The epitope of the anti-gp210 antibody, which contributes to the progression of primary biliary cirrhosis(PBC), was conserved in histone-like protein of Streptococcus intermedius(SI) in mouse PBC model. SI was more frequently isolated from gingivitis lesions of PBC patients than those in controls. However, there were no significant differences of virulence factors and genetic backgrounds between strains from patients with PBC and control.

Research Products

• [Journal Article] Involvement of commensal bacteria may lead to dysregulated inflammatory and autoimmune responses in a mouse model for chronic nonsuppurative destructive cholangitis (2012)
  • Author(s): Haruta I, Kikuchi K, Nakamura M, Miyakawa H, Hirota K, Kato H, Miyakawa H, Shibata N, Miyake Y, Hashimoto E, Shiratori K, Yagi J
  • Journal Title: J. Clin. Immunol Volume: (e-published)
  • Peer Reviewed
• [Journal Article] 感染症四方山話(3):感染症研究との出会い (2012)
  • Author(s): 菊池賢
  • Journal Title: The Chemical Times Volume: 224 Pages: 8-14
• [Journal Article] 感染症四方山話(3):感染症研究との出会い-常在菌と病原菌の狭間に見せられるまで- (2012)
  • Author(s): 菊池賢
  • Journal Title: Chemical Times Volume: 224(印刷中) Pages: 8-14
• [Journal Article] 口腔内細菌と自己免疫疾患 (2011)
  • Author(s): 菊池賢
  • Journal Title: 化学療法の領域 Volume: 27 Pages: 71-78
• [Journal Article] Are dysregulated inflammatory responses to commensal bacteria involved in the pathogenesis of hepato-biliary-pancreatic autoimmune disease? An analysis using mice models of primary biliary cirrhosis and autoimmune pancreatitis (2011)
  • Author(s): Yanagisawa N, Haruta I, Kikuchi K, Shibata N, Yagi J
  • Journal Title: ISRN Gastroenterol Volume: (e-published)
  • Peer Reviewed
• [Journal Article] Are dysregulated inflammatory responses to commensal bacteria involved in the pathogenesis of hepato-biliary-pancreatic autoimmune disease? an analysis using mice models of primary biliary cirrhosis and autoimmune pancreatitis (2011)
  • Author(s): Yanagisawa N, Haruta I, Kikuchi K, Shibata N, Yagi J
  • Journal Title: ISRN Gastroenterol Volume: 2011(2011)(e-publ;ished) Pages: 8-8
  • DOI: 10.5402/2011/513514
  • Peer Reviewed
• [Journal Article] Long-term bacterial exposure can trigger nonsuppurative destructive cholangitis associated with multifocal epithelial inflammation (2010)
  • Author(s): Haruta I, Kikuchi K, Hashimoto E, Nakamura M, Miyakawa H, Hirota K, Shibata N, Kato H, Arimura Y, Kato Y, Uchiyama T, Nagamune H, Kobayashi M, Miyake Y, Shiratori K, Yagi J
  • Journal Title: Lab. Invest Volume: 90 Pages: 577-588
  • Peer Reviewed
• [Journal Article] Role of catabolite control protein A in the regulation of intemedilysin production by Streptococcus intermedius (2010)
  • Author(s): Tomoyasu T, Tabata A, Hiroshima R, Imaki H, Masuda S, Woley RA, Aduse-Opoku J, Kikuchi K, Hiramatsu K, Nagamune H
  • Journal Title: Infect. Immun Volume: 78 Pages: 4012-4021
  • Peer Reviewed
• [Journal Article] 常在菌感染を誘因とする全身疾患-Streptococcus intermediusと原発性胆汁性肝硬変 (2010)
  • Author(s): 菊池賢
  • Journal Title: 無菌生物 Volume: 40 Pages: 39-39
  • NAID: 10026666358
  • Peer Reviewed
• [Journal Article] Role of catabolite control protein A in the regulation of intermedilysin production by Streptococcus intermedius (2010)
  • Author(s): Tomoyasu T, Tabata T, Hiroshima R, Imaki H, Matsuda S, Wiley RA, Aduse-Opoku J, Kikuchi K, Hiramatsu K, Nagamune H
  • Journal Title: Infect.Immun. Volume: 78 Pages: 4012-4021
  • Peer Reviewed
• [Journal Article] Long-term bacterial exposure can trigger nonsuppurative destructive cholangitis associated with multifocal epithelial inflammation (2010)
  • Author(s): Haruta I, Kikuchi K, et al.
  • Journal Title: Laboratory Investigation 40(e-published)
  • Peer Reviewed
• [Presentation] Streptococcus intermediusゲノムにみられる特有のmicrocompartmentを含むgenomic island (2012)
  • Author(s): 菊池賢、松田真理、水谷友紀、馬場理、崔龍洙、平松啓一
  • Organizer: 第21回Lancefieldレンサ球菌研究会
  • Place of Presentation: 大阪大学歯学部(大阪)発表予定
  • Year and Date: 2012-06-08
• [Presentation] Genes encoding bacterial microcompartments and relationship to anerophilic/carbon dioxide dependency (2012)
  • Author(s): 菊池賢、松田真理、馬場理、崔龍洙、平松啓一
  • Organizer: 第85回日本細菌学会総会
  • Place of Presentation: 長崎ブリックホール(長崎)
  • Year and Date: 2012-03-27
• [Presentation] 微生物検査におけるMALDI-TOF MSの可能性 (2012)
  • Author(s): 菊池賢
  • Organizer: 第23回日本臨床微生物学会総会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2012-01-21
• [Presentation] Genes encoding bacterial microcompartments and relationship to anerophilic/carbon dioxide dependency (2012)
  • Author(s): 菊池賢、松田真理, 他
  • Organizer: 第85回日本細菌学会総会
  • Place of Presentation: 長崎
• [Presentation] Genes containing LPXTG motif in Streptococcus intermedius identified from whole genome sequences (2011)
  • Author(s): K ikuchi K, Matsuda M, Baba T, Cui L, Hiramatsu K
  • Organizer: International Union of Microbiological Societies 2011 Congress
  • Place of Presentation: 札幌コンベンションセンター(札幌)
  • Year and Date: 2011-09-07
• [Presentation] ゲノム解析からみStreptococcus intermediusの病原因子 (2011)
  • Author(s): 菊池賢、松田真理、馬場理、崔龍洙、平松啓一
  • Organizer: 第58回毒素シンポジウム
  • Place of Presentation: 順天堂大学(東京)
  • Year and Date: 2011-07-07
• [Presentation] ゲノム解析からみたStreptococcus intermediusの病原因子 (2011)
  • Author(s): 菊池賢
  • Organizer: 第58回毒素シンポジウム
  • Place of Presentation: 栃木県鬼怒川温泉
  • Year and Date: 2011-07-07
• [Presentation] MALDI-TOF MSによるStreptococcus anginosus groupの同定 (2011)
  • Author(s): 菊池賢、松田直人、松田真理、野竹重幸、玉井清子、市川香織、柳沢英二、平松啓一
  • Organizer: 第20回Lancefieldレンサ球菌研究会
  • Place of Presentation: 愛知学院大学薬学部(名古屋)
  • Year and Date: 2011-06-17
• [Presentation] MALDI-TOF MSによるStreptococcus属の同定 (2011)
  • Author(s): 菊池賢、松田直人、松田真理、野竹重幸、玉井清子、柳沢英二、平松啓一
  • Organizer: 第85回日本感染症学会総会
  • Place of Presentation: ザ・プリンスパークタワー東京(東京)
  • Year and Date: 2011-04-22
• [Presentation] Streptococcus intermediusによる化膿性膝関節炎の1例 (2011)
  • Author(s): 紺泰枝、菊池賢
  • Place of Presentation: ザ・プリンスパークタワー東京(東京)
  • Year and Date: 2011-04-22
• [Presentation] Streptococcus intermediusと原発性胆汁性肝硬変 (2011)
  • Author(s): 菊池賢
  • Organizer: 第43回日本無菌生物ノートバイオロジー学会
  • Place of Presentation: 日本大学歯学部(東京)
  • Year and Date: 2011-01-21
• [Presentation] Genes containing LPXTG motif in Streptococcus intermedius identified from whole genome sequences (2011)
  • Author(s): Kikuchi K, Matsuda M, Baba T, Cui L, Hiramatsu K
  • Organizer: International Union of Microbiological Societies 2011 Congress
  • Place of Presentation: 札幌
• [Presentation] MALDI-TOF MSによるStreptococcus属の同定 (2011)
  • Author(s): 菊池賢, 他
  • Organizer: 第85回日本感染症学会総会
  • Place of Presentation: 東京
• [Presentation] Streptococcus intermediusによる化膿性膝関節炎の1例 (2011)
  • Author(s): 紺泰枝、菊池賢
  • Organizer: 第85回日本感染症学会総会
  • Place of Presentation: 東京
• [Presentation] MALDI-TOF MSによるStreptococcus anginosus groupの同定 (2011)
  • Author(s): 菊池賢, 他
  • Organizer: 第21回Lancefieldレンサ球菌研究会
  • Place of Presentation: 名古屋
• [Presentation] 微生物検査におけるMALDI-TOF MSの可能性 (2011)
  • Author(s): 菊池賢
  • Organizer: 第23回日本臨床微生物学会
  • Place of Presentation: 横浜(教育講演)
• [Presentation] 細菌の長期反復投与に惹起される、原発性胆汁性肝硬変様の自己免疫胆管炎マウスモデル作製の試み (2010)
  • Author(s): 春田郁子, 菊池賢, 他
  • Organizer: 第82回日本細菌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-03-13
• [Presentation] Streptococcus intermedius と原発性胆汁性肝硬変(招待講演) (2010)
  • Author(s): 菊池賢
  • Organizer: 第43回無菌生物ノートバイオロジー学会
  • Place of Presentation: 東京
  • Year and Date: 2010-01-22
• [Presentation] Streptococcus intermediusが産生するヒト特異的細胞溶解毒素インターメディリシンの発現調節機構の解析 (2009)
  • Author(s): 友安俊文、田端厚之、菊池賢、佐々木崇、馬場理、平松啓一、長宗秀明
  • Organizer: 第56回毒素シンポジウム
  • Place of Presentation: アルモニーテラッセ(岐阜)
  • Year and Date: 2009-08-28