| Project/Area Number |
21590496
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
YAGI Junji 東京女子医科大学, 医学部, 教授 (70182300)
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| Co-Investigator(Kenkyū-buntansha) |
IMANISHI Ken' ichi 東京女子医科大学, 医学部, 准教授 (20132920)
ARIMURA Yutaka 東京女子医科大学, 医学部, 講師 (10281677)
OMORI Miyuki 東京女子医科大学, 医学部, 助教 (30462667)
KATO Hidehito 東京女子医科大学, 医学部, 助教 (00241084)
HARUTA Ikuko 東京女子医科大学, 医学部, 講師 (80221513)
UESHIBA Hidehiro 東京女子医科大学, 医学部, 助教 (30223449)
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| Co-Investigator(Renkei-kenkyūsha) |
OZAKI Makoto 東京女子医科大学, 医学部, 教授 (30160849)
KOTANI Toru 東京女子医科大学, 医学部, 准教授 (00195736)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 感染免疫 / LECT2 / 敗血症 / 毒素性ショック / 炎症 / 炎症性サイトカイン / 診断 / LECT2受容体 / SEA / D-galactosamine / 敗血症性ショック |
|---|
| Research Abstract |
Using the mouse model of SEA-induced toxicity, LECT2^<-/-> mouse showed exacerbation of multiple organ failure and increase of mortality. The plasma LECT2 level in B6 mouse injected with SEA/D-GalN declined rapidly and increased to the normal level until 72 hours after treatment. The administration of LECT2 suppressed remarkably plasma TNF-and IL-6 levels and increased survival rate. LECT2 appears to be an intrinsic regulatory factor in excess inflammatory responses. In the patients with sepsis, the plasma LECT2 level decreased at acute phase, and increased at recovery phase, suggesting for the first time that LECT2 might be also associated with human inflammatory diseases.
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