• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of immunotherapy and virotherapy against ATL

Research Project

Project/Area Number 21590504
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Virology
Research InstitutionHokkaido University

Principal Investigator

OHASHI Takashi  北海道大学, 遺伝子病制御研究所, 准教授 (10282774)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsHTLV-I / 成人T細胞白血病 / 動物モデル / 免疫治療 / ウイルス療法 / MHC-I / Single chain trimer / ATL / CTL / Tax / Epitope / Vaccinia
Research Abstract

The potential for novel therapies against Human T-cell leukemia virus type I (HTLV-I) induced-adult T-cell leukemia (ATL) has been assessed in a rat model of HTLV-I infection. The results indicate that the single chain trimer (SCT) of MHC-I linked to HTLV-I epitope peptide is able to induce HTLV-I-specific cytotoxic responses and that LC16m8Δ, a highly attenuated vaccinia strain, has an ability to lyse HTLV-I-infected T cells. These results should be useful for further verifying the strategies to fight against HTLV-I.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (18 results)

All 2011 2010 2009 Other

All Journal Article (12 results) (of which Peer Reviewed: 6 results) Presentation (2 results) Remarks (4 results)

  • [Journal Article] Nuclear and cytoplasmic effects of human CRM1 on HIV-1 production in rat cells2011

    • Author(s)
      Nagai-Fukataki M, Ohashi T, Hashimoto I, Kimura T, Hakata Y, Shida H
    • Journal Title

      Genes Cells

      Volume: 16 Pages: 203-216

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Nuclear and cytoplasmic effects of human CRM1 on HIV-1 production in rat cells.2011

    • Author(s)
      Nagai-Fukataki M.
    • Journal Title

      Genes Cells

      Volume: 16 Pages: 203-216

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effect of human TRIM5alpha on HIV-1 production2010

    • Author(s)
      Zhang X., Kondo M., Chen J., Miyoshi H., Suzuki H., Ohashi T., and Shida H
    • Journal Title

      Microbes Infect

      Volume: 12 Pages: 768-777

    • Related Report
      2011 Final Research Report
  • [Journal Article] Inhibitory effect of human TRIM5alpha on HIV-1 production.2010

    • Author(s)
      Zhang X.
    • Journal Title

      Microbes Infect.

      Volume: 12 Pages: 768-777

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of IL-10-and IFN-g-producing T-cell responses by autoreactive T-cells expressing human T-cell leukemia virus type I Tax2009

    • Author(s)
      Takatsuka N., Hasegawa A., Takamori A., Shimizu Y., Kato H., Ohashi T., Amagasa T., Masuda T., Kannagi M
    • Journal Title

      Int. Immunol

      Volume: 21 Issue: 10 Pages: 1089-1100

    • DOI

      10.1016/j.micinf.2010.05.004

    • Related Report
      2011 Final Research Report
  • [Journal Article] Functional analysis of Foxp3 and CTLA-4 expressing HTLV-1-infected cells in a rat model2009

    • Author(s)
      Takayanagi R., Ohashi T., and Shida H
    • Journal Title

      Microbes Infect

      Volume: 11 Issue: 9 Pages: 964-972

    • DOI

      10.1093/intimm/dxp089

    • Related Report
      2011 Final Research Report
  • [Journal Article] Synergistic effect of human CycT1 and CRM1 on HIV-1 propagation in rat T cells and macrophages2009

    • Author(s)
      Okada H., Zhang X., Fofana IB., Nagai M., Suzuki H., Ohashi T., and Shida H
    • Journal Title

      Retrovirology

      Volume: 6 Issue: 12 Pages: 43-43

    • DOI

      10.1016/j.micinf.2009.06.007

    • Related Report
      2011 Final Research Report
  • [Journal Article] Immunogenicity of newly constructed attenuated vaccinia strain LC16m8△ that expresses SIV Gag protein2009

    • Author(s)
      Suzuki H., Kidokoro M., Fofana IB., Ohashi T., Okamura T., Honda M., Yamamoto N., and Shida H
    • Journal Title

      Vaccine

      Volume: 27 Issue: 1 Pages: 966-971

    • DOI

      10.1186/1742-4690-6-43

    • Related Report
      2011 Final Research Report
  • [Journal Article] Induction of IL-10- and IFN-γ-producing T-cell responses by autoreactive T-cells expressing human T-cell leukemia virus type I Tax.2009

    • Author(s)
      Takatsuka N
    • Journal Title

      International Immunology 21

      Pages: 1089-1100

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional analysis of Foxp3 and CTLA-4 expressing HTLV-1-infected cells in a rat model.2009

    • Author(s)
      Takayanagi R.
    • Journal Title

      Microbes and Infection 11

      Pages: 964-972

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synergistic effect of human CycT1 and CRM1 on HIV-1 propagation in rat T cells and macrophages.2009

    • Author(s)
      Okada H.
    • Journal Title

      Retrovirology 6

      Pages: 43-43

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunogenicity of newly constructed attenuated vaccinia strain LC16m8Δ that expresses SIV Gag protein.2009

    • Author(s)
      Suzuki H.
    • Journal Title

      Vaccine 27

      Pages: 966-971

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] ラットモデルを用いた低病原性ワクシニアウイルスの抗HTLV-I腫瘍効果の解析2011

    • Author(s)
      大橋貴、中村貴史、木所稔、志田壽利
    • Organizer
      第4回HTLV-I研究会
    • Place of Presentation
      東京大学弥生講堂
    • Year and Date
      2011-09-19
    • Related Report
      2011 Final Research Report
  • [Presentation] ラットモデルを用いた低病原性ワクシニアウイルスの抗HTLV-I腫瘍効果の解析2011

    • Author(s)
      大橋貴
    • Organizer
      第4回HTLV-I研究会
    • Place of Presentation
      東京大学弥生講堂(東京)
    • Year and Date
      2011-09-19
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.igm.hokudai.ac.jp/molvir/index.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.igm.hokudai.ac.jp/molvir/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.igm.hokudai.ac.jp/molvir/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.igm.hokudai.ac.jp/molvir/index.html

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi