| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
In order to produce the anti-HIV agents effective for the viral variants, we carried out in silico drug design, organic synthesis, and assay of the compound potency. The designed compounds were intended to be targeted on the I84V and V82A mutants of HIV-1 protease. Several compounds were synthesized, and some of the intermediates of the designed compounds showed anti-viral activity. It is required to enhance the compound potency greatly. Accordingly, the modification of the derivatives should be performed to produce a potent agent in our future work.
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