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Elucidation of the molecular mechanism how EB virus induces the pathogenesis by visualizing viral infection

Research Project

Project/Area Number 21590509
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Virology
Research InstitutionOsaka University

Principal Investigator

YASUI Teruhito  大阪大学, 微生物病研究所, 准教授 (60283074)

Co-Investigator(Renkei-kenkyūsha) KIKUTANI Hitoshi  大阪大学, 微生物病研究所, 教授 (80161412)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsEpstein-Barrウイルス / B細胞 / Latent membrane protein / 潜伏感染 / 自己免疫疾患 / ヘルペスウイルス / リンパ腫 / モノクローナル抗体 / 細胞形質転換 / Estein-Barrウイルス
Research Abstract

Epstein-Barr virus is an oncogenic herpesvirus that infects into over 90% of worldwide human beings. To elucidate the molecular pathogenesis in which EB virus induce cell growth transformation, recombinant EB virus was produced to visualize the viral infection and then utilized for identification of host factor that is responsible for the viral entry. Furthermore, the novel cloning strategy for identifying host molecules associated with latent membrane proteins was established to clarify the contribution of the interacting host factor in EB virus infection.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (48 results)

All 2011 2010 2009 Other

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (33 results) Remarks (2 results)

  • [Journal Article] Deleterious effects of lymphocytes at the early stage of neurodegeneration in an animal model of amyotrophic lateral sclerosis2011

    • Author(s)
      Tada S, Okuno T, Yasui T, NakatsujiY, Sugimoto T, Kikutani H, Sakoda S
    • Journal Title

      J Neuroinflammation

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] An immunoreceptor adapter protein, DAP12, suppresses adaptive immune responses mediated by B lymphocytes2011

    • Author(s)
      Nakano-Yokomizo, T., S. Tahara-Hanaoka, C. Nakahashi-Oda, T. Nabekura, N. K. Tchao, M. Kadosaki, N. Totsuka, N. Kurita, K. Nakamagoe, A. Tamaoka, T. Takai, T. Yasui, H. Kikutani, S. Honda, K. Shibuya, L. L. Lanier, A. Shibuya
    • Journal Title

      J. Exp. Med.

      Volume: 208 Pages: 1661-1671

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The immunoreceptor adapter protein DAP12 suppresses B lymphocyte-driven adaptive immune responses2011

    • Author(s)
      Takako Nakano-Yokomizo, et.al.
    • Journal Title

      J Exp Med

      Volume: 8 Issue: 8 Pages: 1661-1671

    • DOI

      10.1084/jem.20101623

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deleterious effects of lymphocytes at the early stage of neurodegeneration in an animal model of amyotrophic lateral sclerosis2011

    • Author(s)
      Tada S.
    • Journal Title

      Journal of Neuroinflammation

      Volume: 8 Issue: 1 Pages: 19-29

    • DOI

      10.1186/1742-2094-8-19

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical role of IkappaB Kinase alpha in TLR7/ 9-induced type I IFN production by conventional dendritic cells2010

    • Author(s)
      Hoshino K, Sasaki I, Sugiyama T, Yano T, Yamazaki C, Yasui T, Kikutani H, Kaisho T
    • Journal Title

      J. Immunol

      Volume: 184 Pages: 3341-3345

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] BS69 cooperates with TRAF3 in the regulation of Epstein-Barr virus-derived LMP1/ CTAR1-induced NF-kB activation2010

    • Author(s)
      Ikeda O, Miyasaka Y, Yoshida R, Mizushima A, Oritani K, Sekine Y, Kuroda M, Yasui T, Fujimuro M, Muromoto R, Nanbo A, Matsuda T
    • Journal Title

      FEBS Lett

      Volume: 584 Pages: 865-872

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] BS69 cooperates with TRAF3 in the regulation of Epstein-Barr virus-derived LMP1/CTAR1-induced NF-kB activation.2010

    • Author(s)
      Ikeda O, et al.
    • Journal Title

      FEBS Lett.

      Volume: 584 Pages: 865-872

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical role of IkappaB Kinase alpha in TLR7/9-induced type I IFN production by conventional dendritic cells.2010

    • Author(s)
      Hoshino K, et al.
    • Journal Title

      J.Immunol.

      Volume: 184 Pages: 3341-3345

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BS69 cooperates with TRAF3 in the regulation of Epstein-Barr virus-derived LMP1/CTAR1-induced NF-kB activation2010

    • Author(s)
      Ikeda O, et al.
    • Journal Title

      FEBS Lett. 584

      Pages: 865-872

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BS69 negatively regulates the canonical NF-kappaB activation induced by Epstein-Barr virus-derived LMP12009

    • Author(s)
      Ikeda O, Sekine Y, Mizushima A, Oritani K, Yasui T, Fujimuro M, Muromoto R, Nanbo A, Matsuda T
    • Journal Title

      FEBS Lett

      Volume: 583 Pages: 1567-74

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced humoral immune responses against T-independent antigens in Fc alpha/ muR-deficient mice2009

    • Author(s)
      Honda S, Kurita N, Miyamoto A, Cho Y, Usui K, Takeshita K, Takahashi S, Yasui T, Kikutani H, Kinoshita T, Fujita T, Tahara-Hanaoka S, Shibuya K, Shibuya A
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 106 Pages: 11230-11255

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced humoral immune responses against T-independent antigens in Fe alpha/muR-deficient mice2009

    • Author(s)
      Honda S, et al.
    • Journal Title

      Proc Natl Acad Sci USA. 106

      Pages: 11230-11235

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BS69 negatively regulates the canonical NF-kappaB activation induced by Epstein-Barr virus-derived LMP12009

    • Author(s)
      Ikeda O, et al.
    • Journal Title

      FEBS Lett. 583

      Pages: 1567-1574

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Novel role of BAFF-BAFF-R interaction in neuroprotection2011

    • Author(s)
      Satoru Tada
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Year and Date
      2011-11-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] アポトーシス細胞と肥満細胞上のCD300aによる炎症応答の調節2011

    • Author(s)
      小田(中橋)ちぐさ
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Year and Date
      2011-11-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Apoptotic cells suppress mast cell inflammatory responses via the CD33a immunoreceptor2011

    • Author(s)
      Chigusa Oda-Nakahashi, Teruhito Yasui
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-27
    • Related Report
      2011 Final Research Report
  • [Presentation] Novel role of BAFF-BAFF-R interaction in neuroprotection2011

    • Author(s)
      Satoru Tada, Teruhito Yasui
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-27
    • Related Report
      2011 Final Research Report
  • [Presentation] EBウイルスLMP2aによるBCRシグナル変化に伴う胚中心B細胞分化抑制2011

    • Author(s)
      南谷武春、安居輝人
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-27
    • Related Report
      2011 Final Research Report
  • [Presentation] An Immunoreceptor adaptor protein, DAP12, suppresses adaptive immune responses mediated by B lymphocytes2011

    • Author(s)
      Satoko Tahara-Hanaoka
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-27
    • Related Report
      2011 Final Research Report
  • [Presentation] A immunoreceptor adaptor protein, DAP12, suppresses adaptive immune responses mediated by B lymphocytes2011

    • Author(s)
      Takako Nakano-Yokomizo
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Year and Date
      2011-11-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] EBウイルスLMP2aによるBCRシグナル変化に伴う胚中心B細胞分化抑制2011

    • Author(s)
      南谷武春
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Year and Date
      2011-11-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Impaired germinal center reaction by Epstein-Barr virus latent membrane protein 2A2011

    • Author(s)
      Takeharu Minamitani, Teruhito Yasui
    • Organizer
      XV International congress of Virology
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2011-09-13
    • Related Report
      2011 Final Research Report
  • [Presentation] Impaired germinal center reaction by Epstein-Bar virus Latent membrane protein 2A2011

    • Author(s)
      Takeharu Minamitani
    • Organizer
      XV International congress of Virology
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2011-09-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] EBウイルスLMP2Aシグナルは胚中心B細胞分化を修飾する2011

    • Author(s)
      南谷武春、安居輝人
    • Organizer
      第8回EBウイルス研究会
    • Place of Presentation
      大阪
    • Year and Date
      2011-07-08
    • Related Report
      2011 Final Research Report
  • [Presentation] Epstein-BarrウイルスLatent membrane protein 2Aシグナルは胚中心B細胞の分化を修飾する2011

    • Author(s)
      南谷武春
    • Organizer
      第8回EBV研究会
    • Place of Presentation
      大阪大学銀杏会館(大阪府)
    • Year and Date
      2011-07-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] Epstein-BarrウイルスLatent membrane protein 2Aシグナルによる胚中心B細胞分化修飾2011

    • Author(s)
      南谷武春、安居輝人
    • Organizer
      第26回ヘルペスウイルス研究会
    • Place of Presentation
      大阪
    • Year and Date
      2011-06-03
    • Related Report
      2011 Final Research Report
  • [Presentation] Epstein-BarrウイルスLatent membrane protein 2Aシグナルによる胚中心B細胞の分化修飾2011

    • Author(s)
      南谷武春
    • Organizer
      第26回ヘルペスウイルス研究会
    • Place of Presentation
      大阪アカデミア(大阪府)
    • Year and Date
      2011-06-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] ERM/ BiFC systemを用いたEBV Latent membrane会合宿主分子の包括的解析2010

    • Author(s)
      安居輝人
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島
    • Year and Date
      2010-11-08
    • Related Report
      2011 Final Research Report
  • [Presentation] ERM/BiFC systemを用いたEBV Latent membrane会合宿主分子の包括的解析2010

    • Author(s)
      安居輝人
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島
    • Year and Date
      2010-11-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Comprehensive detection assay of physiological interaction partners for the Epstein-Barr virus latent membrane protein 1 by bimolecular fluorescence complementation system coupled with enhanced retrovirus mutagenesis2010

    • Author(s)
      Teruhito Yasui
    • Organizer
      The 14^<th> Biennial Conference of the International Association for Research on Epstein-Barr virus & Associated Diseases
    • Place of Presentation
      Birmingham, UK
    • Year and Date
      2010-09-04
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] PKN1 is involved in quality control of germinal center by regulating BCR signaling threshold dependent on the Akt activation2010

    • Author(s)
      Teruhito Yasui, PKC-related kinase
    • Organizer
      The 14^<th> International congress Immunology
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2010-08-23
    • Related Report
      2011 Final Research Report
  • [Presentation] PKC-related kinase, PKN1 is involved in quality control of germinal center by regulating BCR signaling threshold dependent on the Akt activation2010

    • Author(s)
      Teruhito Yasui
    • Organizer
      The 14^<th> International congress Immunology
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2010-08-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] The quality control of humoral immune response by PKC-related kinase, PKN12010

    • Author(s)
      Teruhito Yasui
    • Organizer
      International Symposium on Organelle Network ; Microbiology, Immunology, and Cell Biology
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2010-07-12
    • Related Report
      2011 Final Research Report
  • [Presentation] The quality control of humoral immune response by PKC-related kinase, PKN12010

    • Author(s)
      Teruhito Yasui
    • Organizer
      International Symposium on Organelle Network ; Microbiology, Immunology, and Cell Biology
    • Place of Presentation
      Osaka, Japan(招待講演)
    • Year and Date
      2010-07-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] ERM/ BiFC systemを用いたEBVLatent membrane会合宿主分子の包括的解析2010

    • Author(s)
      安居輝人
    • Organizer
      第7回EBウイルス研究会
    • Place of Presentation
      札幌
    • Year and Date
      2010-07-09
    • Related Report
      2011 Final Research Report
  • [Presentation] ERM/BiFC systemを用いたEBV Latent membrane会合宿主分子の包括的解析2010

    • Author(s)
      安居輝人
    • Organizer
      第7回EBウイルス研究会
    • Place of Presentation
      札幌
    • Year and Date
      2010-07-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] A role of lymphocytes in an animal model of inheritad ALS2010

    • Author(s)
      Satoru Tada, Teruhito Yasui
    • Organizer
      The 4^<th> International RIMD-CVRDC joint symposium
    • Place of Presentation
      Okayama, Japan
    • Year and Date
      2010-06-17
    • Related Report
      2011 Final Research Report
  • [Presentation] Murine herpescirus 68組換えウイルスの作成と潜伏感染動態の解析2010

    • Author(s)
      森本智美、安居輝人
    • Organizer
      第25回ヘルペスウイルス研究会
    • Place of Presentation
      静岡
    • Year and Date
      2010-05-27
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] EBV膜蛋白の細胞形質転換機構2010

    • Author(s)
      安居輝人
    • Organizer
      平成21年度遺伝子病研究所研究集会
    • Place of Presentation
      札幌
    • Year and Date
      2010-01-18
    • Related Report
      2011 Final Research Report
  • [Presentation] PKN1はAkt依存性BCRシグナル閥値を制御することによって抗体親和性成熟をコントロールする2009

    • Author(s)
      安居輝人, 外6人
    • Organizer
      第39回日本免疫学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] PKN1はAkt依存性BCRシグナル閾値を制御することによって抗体親和性成熟をコントロールする2009

    • Author(s)
      安居輝人
    • Organizer
      第39回日本免疫学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-03
    • Related Report
      2011 Final Research Report
  • [Presentation] GPIアンカー型タンパク質のラフトへの局在に免疫寛容が重要である2009

    • Author(s)
      Yeteo Wang、安居輝人
    • Organizer
      第39回日本免疫学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-03
    • Related Report
      2011 Final Research Report
  • [Presentation] BS69によるEBウイルス遺伝子産物LMP1の活性制御機構の解析2009

    • Author(s)
      池田收、安居輝人
    • Organizer
      第39回日本免疫学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 発現制御可能なEBウイルスlatent membrane protein 2Aトランスジェニックマウスを用いたB細胞分化修飾機構の解析2009

    • Author(s)
      安居輝人
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-27
    • Related Report
      2011 Final Research Report
  • [Presentation] 現制御可能なトランスジェニックマウスを用いたEBウイルスlatent membraneproteinによるB細胞分化修飾機構の解析2009

    • Author(s)
      安居輝人
    • Organizer
      第6回EBウイルス研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-09
    • Related Report
      2011 Final Research Report
  • [Presentation] EBウイルスlatent membraneproteinによるB細胞分化修飾機構の解析2009

    • Author(s)
      安居輝人
    • Organizer
      第24回ヘルペスウイルス研究会
    • Place of Presentation
      静岡
    • Year and Date
      2009-07-04
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.biken.osaka-u.ac.jp/biken/mol-imm/Molecular_Immunology/Welcome.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.biken.osaka-u.ac.jp/biken/mol-imm/Molecular_Immunology/Welcome.html

    • Related Report
      2011 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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