Elucidation of the molecular mechanism how EB virus induces the pathogenesis by visualizing viral infection
| Project/Area Number |
21590509
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Osaka University |
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Principal Investigator |
YASUI Teruhito 大阪大学, 微生物病研究所, 准教授 (60283074)
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| Co-Investigator(Renkei-kenkyūsha) |
KIKUTANI Hitoshi 大阪大学, 微生物病研究所, 教授 (80161412)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | Epstein-Barrウイルス / B細胞 / Latent membrane protein / 潜伏感染 / 自己免疫疾患 / ヘルペスウイルス / リンパ腫 / モノクローナル抗体 / 細胞形質転換 / Estein-Barrウイルス |
|---|
| Research Abstract |
Epstein-Barr virus is an oncogenic herpesvirus that infects into over 90% of worldwide human beings. To elucidate the molecular pathogenesis in which EB virus induce cell growth transformation, recombinant EB virus was produced to visualize the viral infection and then utilized for identification of host factor that is responsible for the viral entry. Furthermore, the novel cloning strategy for identifying host molecules associated with latent membrane proteins was established to clarify the contribution of the interacting host factor in EB virus infection.
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Report
(4 results)
Research Products
(48 results)
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[Journal Article] An immunoreceptor adapter protein, DAP12, suppresses adaptive immune responses mediated by B lymphocytes2011
Author(s)
Nakano-Yokomizo, T., S. Tahara-Hanaoka, C. Nakahashi-Oda, T. Nabekura, N. K. Tchao, M. Kadosaki, N. Totsuka, N. Kurita, K. Nakamagoe, A. Tamaoka, T. Takai, T. Yasui, H. Kikutani, S. Honda, K. Shibuya, L. L. Lanier, A. Shibuya
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Journal Title
J. Exp. Med.
Volume: 208
Pages: 1661-1671
Related Report
Peer Reviewed
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[Journal Article] BS69 cooperates with TRAF3 in the regulation of Epstein-Barr virus-derived LMP1/ CTAR1-induced NF-kB activation2010
Author(s)
Ikeda O, Miyasaka Y, Yoshida R, Mizushima A, Oritani K, Sekine Y, Kuroda M, Yasui T, Fujimuro M, Muromoto R, Nanbo A, Matsuda T
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Journal Title
FEBS Lett
Volume: 584
Pages: 865-872
Related Report
Peer Reviewed
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[Journal Article] Enhanced humoral immune responses against T-independent antigens in Fc alpha/ muR-deficient mice2009
Author(s)
Honda S, Kurita N, Miyamoto A, Cho Y, Usui K, Takeshita K, Takahashi S, Yasui T, Kikutani H, Kinoshita T, Fujita T, Tahara-Hanaoka S, Shibuya K, Shibuya A
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Journal Title
Proc Natl Acad Sci USA
Volume: 106
Pages: 11230-11255
Related Report
Peer Reviewed
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