Regulation of genome replication of negative-strand RNA virus by an accessory protein
| Project/Area Number |
21590510
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Virology
|
|---|
| Research Institution | Hiroshima University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
IRIE Takashi 広島大学, 大学院・医歯薬学総合研究科, 准教授 (70419498)
KIYOTANI Katsuhiro 広島大学, 大学院・医歯薬学総合研究科, 講師 (00106824)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | ウイルス / パラミクソウイルス / センダイウイルス / ゲノム極性 / C蛋白質 / プロモーター / cDNAからのウイルス産生系 / cDNAからのウイルス作成系 |
|---|
| Research Abstract |
Infection experiments with the C protein-deficient Sendai virus, which has a single-stranded negative-sense RNA as a genome, suggested that the C protein was involved in regulation of RNA genome polarity during genome replication. The C protein appeared to suppress genomic RNA synthesis in a promoter-dependent fashion, resulting that progeny viruses dominantly had a negative-sense RNA genome. This regulation seems to be related with interferon-βinduction. We also tested other closely related viruses for the regulation.
|
Report
(4 results)
Research Products
(38 results)
-
-
[Journal Article] Optineurin with amyotrophic lateral sclerosis-related mutations abrogates inhibition of interferon regulatory factor-3 activation2011
Author(s)
Sakaguchi, T., Irie, T., Kawabata, R., Yoshida, A., Maruyama, H., Kawakami, H.
-
Journal Title
Neuroscience letters
Volume: vol.505
Pages: 279-281
NAID
Related Report
Peer Reviewed
-
[Journal Article] Analysis of interaction of Sendai virus V protein and melanoma differentiation-associated gene 52011
Author(s)
Sakaguchi, T., Irie, T., Kuwayama, M., Ueno, T., Yoshida, A., Kawabata, R.
-
Journal Title
Microbiology and Immunology
Volume: vol.55
Pages: 760-767
NAID
Related Report
Peer Reviewed
-
[Journal Article] Decreased expression in nuclear factor-κB essential modulator due to a novel splice-site mutation causes X-linked ectodermal dysplasia with immunodeficiency2011
Author(s)
Karakawa, S., Okada, S., Tsumura, M., Mizoguchi, Y., Ohno, N., Yasunaga, S., Otsubo, M., Kawai, T., Nishikomori, R., Sakaguchi, T., Takihara, T., Kobayashi, M.
-
Journal Title
Journal of Clinical Immunology
Volume: vol.31
Pages: 762-772
Related Report
Peer Reviewed
-
[Journal Article] Oncolytic vesicular stomatitis virus administered by isolated limb perfusion suppresses osteosarcoma growth.2011
Author(s)
Kubo, T., Shimose, S., Matsuo, T., Fujimori, J., Sakaguchi, T., Yamaki, M., Shinozaki, K., Woo, S. L., Ochi M.
-
Journal Title
Journal of Orthopaedic Research
Volume: vol.29
Pages: 795-800
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
