• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Analysis of the mechanism of Aichi virus replication complex formation.

Research Project

Project/Area Number 21590514
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Virology
Research InstitutionFujita Health University

Principal Investigator

SASAKI Jun  藤田保健衛生大学, 医学部, 講師 (70319268)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsアイチウイルス / 宿主因子 / ゲノム複製 / ACBD3 / PI4KB / PI4P / ピコルナウイルス
Research Abstract

Aichi virus is thought to be a causative agent of acute gastroenteritis in humans. Understanding the mechanism of the growth of pathogens is required for effective control of infectious diseases ; however, the mechanism of Aichi virus replication remains to be cleared. In this study, two host factors essential for Aichi virus replication were identified. The studies on other viruses report that these host proteins are involved in replication of the viruses. Findings in this study, together with the other studies, may lead to the development of drugs to control infection or growth of multiple viruses.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (12 results)

All 2012 2011 2010 2009

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (6 results)

  • [Journal Article] ACBD3? mediated recruitment of PI4KB to picornavirus RNA replication sites2012

    • Author(s)
      Sasaki J, Ishikawa K, Arita M, Taniguchi K
    • Journal Title

      EMBO J

      Volume: 31 Pages: 754-766

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 3CD, but not 3C, cleaves the VP1/2A site efficiently during Ai chi virus polyprotein processing through interaction with 2A2012

    • Author(s)
      Sasaki J, Ishikawa K, Taniguchi K
    • Journal Title

      Virus Res

      Volume: 163 Pages: 592-598

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] ACBD3-mediated recruitment of PI4KB to picornavirus RNA replication sites2012

    • Author(s)
      Sasaki J, Ishikawa K, Arita M, Taniguchi K
    • Journal Title

      EMBO J

      Volume: 31 Issue: 3 Pages: 754-766

    • DOI

      10.1038/emboj.2011.429

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 3CD, but not 3C, cleaves the VP1/2A site efficiently during Aichi virus polyprotein processing through interaction with 2A2012

    • Author(s)
      Sasaki J, Ishikawa K, Taniguchi K
    • Journal Title

      Virus Res

      Volume: 163 Issue: 2 Pages: 592-598

    • DOI

      10.1016/j.virusres.2011.12.013

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overall linkage map of the nonstructural proteins of Aichi virus2010

    • Author(s)
      Ishikawa K, Sasaki J, Taniguchi K
    • Journal Title

      Virus Res

      Volume: 147 Pages: 77-84

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Overall linkage map of the nonstructural proteins of Aichi virus2010

    • Author(s)
      Ishikawa K
    • Journal Title

      Virus Research 147

      Pages: 77-84

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] A Golgi protein interacting with 2B, 2BC, 2C, 3A and 3AB is a host factor required for Ai chi virus RNA replication2011

    • Author(s)
      Ishikawa K, Sasaki J, Maeno Y, Moriguchi K, Komoto S, Taniguchi K
    • Organizer
      International Union of Microbiological Societies 2011 Congress
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2011-09-15
    • Related Report
      2011 Final Research Report
  • [Presentation] A Golgi protein interacting with 2B, 2BC, 2C, 3A and 3AB is a host factor required for Aichi virus RNA replication2011

    • Author(s)
      Ishikawa K, Sasaki J, Maeno Y, Moriguchi K, Komoto S, Taniguchi K
    • Organizer
      International Union of Microbiological Societies 2011 Congress
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Related Report
      2011 Annual Research Report
  • [Presentation] アイチウイルス3CDによる2AのN末端の切断2009

    • Author(s)
      佐々木潤、石川球美子、前野芳正、河本聡志、守口匡子、谷口孝喜
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      東京都都市センターホテル
    • Year and Date
      2009-10-25
    • Related Report
      2011 Final Research Report
  • [Presentation] アイチウイルス3CDによる2AのN末端の切断2009

    • Author(s)
      佐々木潤
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      東京都 都市センターホテル
    • Year and Date
      2009-10-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Cleavage at the N-terminus of 2A by 3CD of Aichi virus2009

    • Author(s)
      Sasaki J, Ishikawa K, Taniguchi K
    • Organizer
      第9回あわじしま感染症・免疫フォーラム
    • Place of Presentation
      兵庫県淡路市兵庫県立淡路夢舞台国際会議場
    • Year and Date
      2009-09-10
    • Related Report
      2011 Final Research Report
  • [Presentation] Cleavage at the N-terminus of 2A by 3CD of Aichi virus2009

    • Author(s)
      佐々木潤
    • Organizer
      第9回あわじしま感染症・免疫フォーラム
    • Place of Presentation
      兵庫県淡路市 兵庫県立淡路夢舞台国際会議場
    • Year and Date
      2009-09-10
    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi