Approaches to establish the novel antiviral strategies focused on assembly and budding of highly pathogenic viruses

• Project/Area Number: 21590518
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Virology
• Research Institution: Nagasaki University (2010-2011); National Research Institute of Police Science (2009)
• Principal Investigator: YASUDA Jiro 長崎大学, 熱帯医学研究所, 教授 (10282518)
• Co-Investigator(Renkei-kenkyūsha): KUROSAKI Yohei 長崎大学, 熱帯医学研究所, 助教 (40415443)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: Tetherin / 抗ウイルス / インフルエンザウイルス / ハザラウイルス / 出血熱ウイルス / エボラウイルス / クリミア・コンゴ出血熱ウイルス / マールブルグウイルス / ラッサウイルス

Research Abstract

In this study, to establish novel antiviral strategies against highly pathogenic viruses, we analyzed the action mechanism of the antiviral cellular factor, Tetherin, and its antiviral spectrum. We demonstrated that Tetherin has the antiviral activities against influenza and Hazara viruses as well as Lassa and Marburg viruses.

Research Products

• [Journal Article] Ebolavirus replication and tetherin/ BST-2 (2012)
  • Author(s): *Yasuda, J.
  • Journal Title: Frontiers in Microbiology Volume: 3 Pages: 111-111
  • Peer Reviewed
• [Journal Article] Ebolavirus replication and tetherin/BST-2 (2012)
  • Author(s): Yasuda, J.
  • Journal Title: Frontiers in Microbiology Volume: 3 Pages: 1-5
  • DOI: 10.3389/fmicb.2012.00111
  • Peer Reviewed
• [Journal Article] Rapid detection of Lassa virus by reverse transcription. loop-mediated isothermal amplification (2011)
  • Author(s): Fukuma, A., Kurosaki, Y., Morikawa, Y., Grolla, A., Feldmann, H., and* Yasuda, J.
  • Journal Title: Microbiology and Immunology Volume: 55 Pages: 44-50
  • NAID: 10031121439
  • Peer Reviewed
• [Journal Article] Cloning and Characterization of the Antiviral Activity of Feline Tetherin/ BST-2 (2011)
  • Author(s): Fukuma, A., Abe, M., Morikawa, Y., Miyazawa, T., and* Yasuda, J.
  • Journal Title: PLoS One Volume: 6
  • NAID: 120006985155
• [Journal Article] Rapid detection of Lassa virus by reverse transcription-loop-mediated isothermal amplification. (2011)
  • Author(s): Fukuma, A., Kurosaki, Y., Morikawa, Y., Grolla, A., Feldmann, H., Yasuda, J.
  • Journal Title: Microbiology and Immunology Volume: 55 Pages: 44-50
  • NAID: 10031121439
  • Peer Reviewed
• [Journal Article] Cloning and Characterization of the Antiviral Activity of Feline Tetherin/BST-2. (2011)
  • Author(s): Fukuma, A., Abe, M., Morikawa, Y.Miyazawa, T., Yasuda, J.
  • Journal Title: PLoS One Volume: 6
  • NAID: 120006985155
  • Peer Reviewed
• [Journal Article] Marburg virus budding : ESCRT of progeny virion to the outside of the cell (2010)
  • Author(s): *Yasuda, J.
  • Journal Title: Future Virology Volume: 5 Pages: 627-637
  • Peer Reviewed
• [Journal Article] Marburg virus budding : ESCRT of progeny virion to the outside of the cell. (2010)
  • Author(s): Yasuda, J.
  • Journal Title: Future Virology Volume: 5 Pages: 627-637
  • Peer Reviewed
• [Journal Article] Dimerization of tetherin is not essential for its antiviral activity against Lassa and Marburg viruses (2009)
  • Author(s): Sakuma, T., Sakurai, A., and* Yasuda, J.
  • Journal Title: PLoS One Volume: 4
  • Peer Reviewed
• [Journal Article] Dimerization of tetherin is not essential for its antiviral activity against Lassa and Marburg viruses (2009)
  • Author(s): Sakuma, T, Sakurai, A., Yasuda, J.
  • Journal Title: PLoS One 4
  • Peer Reviewed
• [Presentation] Anti-Tetherin activities of Zaire and Reston ebolavirus glycoprotein (2011)
  • Author(s): Yohei Kurosaki, Ayato Takada, Jiro Yasuda
  • Organizer: In" The XVth International Congress of Virology, Sapporo
• [Presentation] Tetherin/ BST-2 functions as an antiviral cellular factor against influenza virus (2011)
  • Author(s): Takeda E., . Sakurai A., Takasita E. and Yasuda J.
  • Organizer: In" The XVth International Congress of Virology
  • Place of Presentation: Sapporo
• [Presentation] Anti-Tetherin activities of Zaire and Reston ebolavirus glycoprotein (2011)
  • Author(s): Kurosaki, Y., Takada, A., Yasuda, J.
  • Organizer: The XVth International Congress of Virology
  • Place of Presentation: Sapporo、(北海道)
• [Presentation] Tetherin/BST-2 functions as an antiviral cellular factor against influenza virus (2011)
  • Author(s): Takeda E., Sakurai A., Takashita E., Yasuda J.
  • Organizer: The XVth International Congress of Virology
  • Place of Presentation: Sapporo、(北海道)
• [Presentation] ANTIVIRAL ACTIVITY OF TETHERIN/BST-2 AGAINST NEGATIVE STRAND RNA VIRUSES. (2010)
  • Author(s): Yasuda, J., Sakurai, A., Noda, T., Urata, S., Kawaoka, Y., Sakuma, T.
  • Organizer: The XIVth International Conference on Negative Strand Viruses
  • Place of Presentation: Brugge, Belgium
  • Year and Date: 2010-06-23
• [Presentation] エボラウイルス表面糖タンパク質GPによる抗ウイルス因子BST-2/ Tetherinの活性阻害 (2010)
  • Author(s): 黒崎陽平、安田二朗
  • Organizer: 33回日本分子生物学会年会BMB2010
  • Place of Presentation: 神戸
• [Presentation] Bst-2/ Tetherinによるハザラウイルス放出抑制機構の解析 (2010)
  • Author(s): 西村聡子、安田二朗
  • Organizer: 第33回日本分子生物学会年会BMB2010
  • Place of Presentation: 神戸
• [Presentation] エボラウイルス表面糖タンパク質GPによるBST-2/ Tetherinの活性阻害 (2010)
  • Author(s): 黒崎陽平、安田二朗
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: 徳島
• [Presentation] ANTIVIRAL ACTIVITY OF TETHERIN/ BST-2 AGAINST NEGATIVE STRAND RNA VIRUSES (2010)
  • Author(s): Yasuda, J., Sakurai, A., Noda, T., Urata, S., Kawaoka, Y., and Sakuma, T.
  • Organizer: In" The XIVth International Conference on Negative Strand Viruses"
  • Place of Presentation: Brugge, Belgium
• [Presentation] エボラウイルス表面糖タンパク質GPによるBST-2/Tetherinの活性阻害 (2010)
  • Author(s): 黒崎陽平、安田二朗
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: 徳島(あわぎんホール)
• [Presentation] エボラウイルス表面糖タンパク質GPによる抗ウイルス因子BST-2/Tetherinの活性阻害 (2010)
  • Author(s): 黒暗陽平、安田二朗
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸(国際会議場)
• [Presentation] Bst-2/Tetherinによるハザラウイルス放出抑制機構の解析 (2010)
  • Author(s): 西村聡子、安田二朗
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸(国際会議場)
• [Presentation] Antiviral mechanism of BST-2/ tetherin (2009)
  • Author(s): 安田二朗、櫻井陽、佐久間稔惠
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] Antiviral mechanism of BST-2/tetherin (2009)
  • Author(s): 安田二朗、櫻井陽、佐久間稔恵
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Remarks]
  • URL: http://www.tm.nagasaki-u.ac.jp/emerging/index.html