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Approaches to establish the novel antiviral strategies focused on assembly and budding of highly pathogenic viruses

Research Project

Project/Area Number 21590518
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Virology
Research InstitutionNagasaki University (2010-2011)
National Research Institute of Police Science (2009)

Principal Investigator

YASUDA Jiro  長崎大学, 熱帯医学研究所, 教授 (10282518)

Co-Investigator(Renkei-kenkyūsha) KUROSAKI Yohei  長崎大学, 熱帯医学研究所, 助教 (40415443)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsTetherin / 抗ウイルス / インフルエンザウイルス / ハザラウイルス / 出血熱ウイルス / エボラウイルス / クリミア・コンゴ出血熱ウイルス / マールブルグウイルス / ラッサウイルス
Research Abstract

In this study, to establish novel antiviral strategies against highly pathogenic viruses, we analyzed the action mechanism of the antiviral cellular factor, Tetherin, and its antiviral spectrum. We demonstrated that Tetherin has the antiviral activities against influenza and Hazara viruses as well as Lassa and Marburg viruses.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (25 results)

All 2012 2011 2010 2009 Other

All Journal Article (10 results) (of which Peer Reviewed: 9 results) Presentation (14 results) Remarks (1 results)

  • [Journal Article] Ebolavirus replication and tetherin/ BST-22012

    • Author(s)
      *Yasuda, J.
    • Journal Title

      Frontiers in Microbiology

      Volume: 3 Pages: 111-111

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ebolavirus replication and tetherin/BST-22012

    • Author(s)
      Yasuda, J.
    • Journal Title

      Frontiers in Microbiology

      Volume: 3 Pages: 1-5

    • DOI

      10.3389/fmicb.2012.00111

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid detection of Lassa virus by reverse transcription. loop-mediated isothermal amplification2011

    • Author(s)
      Fukuma, A., Kurosaki, Y., Morikawa, Y., Grolla, A., Feldmann, H., and* Yasuda, J.
    • Journal Title

      Microbiology and Immunology

      Volume: 55 Pages: 44-50

    • NAID

      10031121439

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cloning and Characterization of the Antiviral Activity of Feline Tetherin/ BST-22011

    • Author(s)
      Fukuma, A., Abe, M., Morikawa, Y., Miyazawa, T., and* Yasuda, J.
    • Journal Title

      PLoS One

      Volume: 6

    • NAID

      120006985155

    • Related Report
      2011 Final Research Report
  • [Journal Article] Rapid detection of Lassa virus by reverse transcription-loop-mediated isothermal amplification.2011

    • Author(s)
      Fukuma, A., Kurosaki, Y., Morikawa, Y., Grolla, A., Feldmann, H., Yasuda, J.
    • Journal Title

      Microbiology and Immunology

      Volume: 55 Pages: 44-50

    • NAID

      10031121439

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cloning and Characterization of the Antiviral Activity of Feline Tetherin/BST-2.2011

    • Author(s)
      Fukuma, A., Abe, M., Morikawa, Y.Miyazawa, T., Yasuda, J.
    • Journal Title

      PLoS One

      Volume: 6

    • NAID

      120006985155

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Marburg virus budding : ESCRT of progeny virion to the outside of the cell2010

    • Author(s)
      *Yasuda, J.
    • Journal Title

      Future Virology

      Volume: 5 Pages: 627-637

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Marburg virus budding : ESCRT of progeny virion to the outside of the cell.2010

    • Author(s)
      Yasuda, J.
    • Journal Title

      Future Virology

      Volume: 5 Pages: 627-637

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dimerization of tetherin is not essential for its antiviral activity against Lassa and Marburg viruses2009

    • Author(s)
      Sakuma, T., Sakurai, A., and* Yasuda, J.
    • Journal Title

      PLoS One

      Volume: 4

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dimerization of tetherin is not essential for its antiviral activity against Lassa and Marburg viruses2009

    • Author(s)
      Sakuma, T, Sakurai, A., Yasuda, J.
    • Journal Title

      PLoS One 4

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Anti-Tetherin activities of Zaire and Reston ebolavirus glycoprotein2011

    • Author(s)
      Yohei Kurosaki, Ayato Takada, Jiro Yasuda
    • Organizer
      In" The XVth International Congress of Virology, Sapporo
    • Related Report
      2011 Final Research Report
  • [Presentation] Tetherin/ BST-2 functions as an antiviral cellular factor against influenza virus2011

    • Author(s)
      Takeda E., . Sakurai A., Takasita E. and Yasuda J.
    • Organizer
      In" The XVth International Congress of Virology
    • Place of Presentation
      Sapporo
    • Related Report
      2011 Final Research Report
  • [Presentation] Anti-Tetherin activities of Zaire and Reston ebolavirus glycoprotein2011

    • Author(s)
      Kurosaki, Y., Takada, A., Yasuda, J.
    • Organizer
      The XVth International Congress of Virology
    • Place of Presentation
      Sapporo、(北海道)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Tetherin/BST-2 functions as an antiviral cellular factor against influenza virus2011

    • Author(s)
      Takeda E., Sakurai A., Takashita E., Yasuda J.
    • Organizer
      The XVth International Congress of Virology
    • Place of Presentation
      Sapporo、(北海道)
    • Related Report
      2011 Annual Research Report
  • [Presentation] ANTIVIRAL ACTIVITY OF TETHERIN/BST-2 AGAINST NEGATIVE STRAND RNA VIRUSES.2010

    • Author(s)
      Yasuda, J., Sakurai, A., Noda, T., Urata, S., Kawaoka, Y., Sakuma, T.
    • Organizer
      The XIVth International Conference on Negative Strand Viruses
    • Place of Presentation
      Brugge, Belgium
    • Year and Date
      2010-06-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] エボラウイルス表面糖タンパク質GPによる抗ウイルス因子BST-2/ Tetherinの活性阻害2010

    • Author(s)
      黒崎陽平、安田二朗
    • Organizer
      33回日本分子生物学会年会BMB2010
    • Place of Presentation
      神戸
    • Related Report
      2011 Final Research Report
  • [Presentation] Bst-2/ Tetherinによるハザラウイルス放出抑制機構の解析2010

    • Author(s)
      西村聡子、安田二朗
    • Organizer
      第33回日本分子生物学会年会BMB2010
    • Place of Presentation
      神戸
    • Related Report
      2011 Final Research Report
  • [Presentation] エボラウイルス表面糖タンパク質GPによるBST-2/ Tetherinの活性阻害2010

    • Author(s)
      黒崎陽平、安田二朗
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島
    • Related Report
      2011 Final Research Report
  • [Presentation] ANTIVIRAL ACTIVITY OF TETHERIN/ BST-2 AGAINST NEGATIVE STRAND RNA VIRUSES2010

    • Author(s)
      Yasuda, J., Sakurai, A., Noda, T., Urata, S., Kawaoka, Y., and Sakuma, T.
    • Organizer
      In" The XIVth International Conference on Negative Strand Viruses"
    • Place of Presentation
      Brugge, Belgium
    • Related Report
      2011 Final Research Report
  • [Presentation] エボラウイルス表面糖タンパク質GPによるBST-2/Tetherinの活性阻害2010

    • Author(s)
      黒崎陽平、安田二朗
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島(あわぎんホール)
    • Related Report
      2010 Annual Research Report
  • [Presentation] エボラウイルス表面糖タンパク質GPによる抗ウイルス因子BST-2/Tetherinの活性阻害2010

    • Author(s)
      黒暗陽平、安田二朗
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸(国際会議場)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Bst-2/Tetherinによるハザラウイルス放出抑制機構の解析2010

    • Author(s)
      西村聡子、安田二朗
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸(国際会議場)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Antiviral mechanism of BST-2/ tetherin2009

    • Author(s)
      安田二朗、櫻井陽、佐久間稔惠
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] Antiviral mechanism of BST-2/tetherin2009

    • Author(s)
      安田二朗、櫻井陽、佐久間稔恵
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.tm.nagasaki-u.ac.jp/emerging/index.html

    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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