| Project/Area Number |
21590525
|
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
|
|---|
| Research Institution | National Hospital Organization Nagoya Medical Center |
|---|
Principal Investigator |
IWATANI Yasumasa 独立行政法人国立病院機構(名古屋医療センター臨床研究センター), 感染・免疫研究部, 室長 (90303403)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ウィルス / 生体分子 / 酵素 / 蛋白質 / 生体防御因子 |
|---|
| Research Abstract |
The human APOBEC3 family(A, B, C, DE, F, G, and H) proteins are cellular defense factors that potently inhibit the replication of retroviruses, including HIV. In order to clarify the anti-viral mechanism, we determined the biochemical characteristics of the enzymes. Furthermore, we identified four ubiquitination sites of APOBEC3G that are critical for HIV Vif-mediated degradation. Our findings will provide important informationto further understand the molecular mechanisms of Anti-viral activities as well as to develop attractive strategies utilizing potential endogenous inhibitors against HIV.
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