Signal transduction of TLR by STM/Hrs

Research Project

Project/Area Number	21590527
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Immunology
Research Institution	Iwaki Meisei University
Principal Investigator	MURATA Kazuko いわき明星大学, 薬学部, 教授 (20137631)
Co-Investigator(Kenkyū-buntansha)	SUGAMURA Kazuo 宮城県立がんセンター研究所, 特任部長 (20117360) NAGATA Takayuki いわき明星大学, 薬学部, 助手 (50553202)
Project Period (FY)	2009 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	自然免疫 / 小胞輸送 / 蛋白質分解 / TLR / シグナル伝達
Research Abstract	We investigated the effects of STAM1/2 on innate immunity, in particular, on the degradation of Toll-like receptor(TLR) family members TLR4.STAMs may play an important role in the lysosomal degradation and translocation of TLR4 upon stimulation with LPS. These observations suggest that STAMs function as negative regulators of innate immunity mediated by TLR4.