Identification of ubiquitin-dependent endosomal sorting signal in cytokine receptors
| Project/Area Number |
21590530
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KOJIMA Katsuhiko 信州大学, 医学部, 助教 (80345743)
YOSHINO Kazuhisa 信州大学, 医学部, 助教 (40551859)
AMANO Yuji 信州大学, 医学部, 助教 (50624681)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 小胞輸送 / サイトカイン受容体 / エンドソーム / ユビキチン / 小胞輸送シグナル |
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| Research Abstract |
In immune or nerve system, intracellular compartments maintain the function, which is supported by endosomal sorting, keeps the specific substances of the system and exchanges the substances between the compartments without physiological and morphological disorder. Here, we showed ubiquitin-independent endosomal sorting of interleukin-2 receptorβ(IL-2Rβ) and identified a novel endosomal sorting signal in the cytoplasmic region of IL-2Rβ. Our report provides the first description of endosomal sorting signal in a ubiquitin-independent manner.
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Report
(4 results)
Research Products
(9 results)
