Development of a new therapy for Crohn's disease by using immuno-regulatory function of NOD2
| Project/Area Number |
21590532
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | クローン病 / NOD2 / TLR / 粘膜免疫 |
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| Research Abstract |
Healthy gut mucosa exhibit tolerogenic responses to intestinal microflora. Excessive immune-reactions against intestinal microflora lead to the development of inflammatory bowel diseases. Mutations in NOD2 are associated with the development of Crohn's disease. Elucidation of mechanisms by which NOD2 mutations cause Crohn's disease provides new insights in the pathogenesis of colitis. Here we show that NOD2 activation inhibits both NF-. B activation and type I IFN production mediated by TLRs.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Activation of Toll-like receptors and NOD-like receptors is involved in enhanced IgG4 responses in autoimmune pancreatitis.2012
Author(s)
Watanabe T, Yamashita K, Fujikawa S, Sakurai T, Kudo M, Shiokawa, M, Kodama Y, Uchida K, Okazaki K, Chiba T.
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Journal Title
Arthritis & Rheumatism
Volume: 64
Issue: 3
Pages: 914-24
DOI
NAID
Related Report
Peer Reviewed
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