| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
Regulatory T (Treg) cells engage in the maintenance of immunological self-tolerance. The transcription factor Foxp3 has been recognized as a master regulator of Treg cells, yet the molecular mechanisms by which Foxp3 controls its target genes still remain elusive. By characterizing transcriptional complexes containing Foxp3, we found that the T cell-specific transcription factor Bcl11b and genome organizer Satb1 were important for exerting Treg functions. Bcl11b-deficient Treg cells lost suppressive activity, resulting in the development of severe autoimmune diseases. In Satb1-deficinet mice, Treg cells lost the Treg-specific DNA hypomethylation pattern. These results indicate that Bcl11b and Satb1 are essential constituents of Foxp3-containing complexes for exerting Treg-specific transcriptional regulation.
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