The role of Notch signaling in the development and maintenance of memory T cells

• Project/Area Number: 21590536
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Immunology
• Research Institution: The University of Tokushima
• Principal Investigator: MAEKAWA Yoichi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (10294670)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 免疫記憶 / CD4陽性Tリンパ球 / 感染症 / リーシュマニア / ワクチン / 免疫学的記憶 / メモリーT細胞 / リーシュマニア原虫 / 濾胞性T細胞 / Notch / メモリーTリンパ球 / Leishmania major原虫感染

Research Abstract

Immunological memory is essential for providing protection against recurrent infection. However, it is still unknown the molecular mechanism underlying the development and maintenance of memory T cells. Here, we found that the mice bearing Notch signaling-deficient T cells did not show the protective immune response against secondary Leishmania major infection, indicating that Notch signaling is critical for memory T cell survival after antigen stimulation.

Research Products

• [Journal Article] Notch2 regulates the development of marginal zone B cells through Fos (2012)
  • Author(s): Iwahashi S, Maekawa Y, Nishida J, Ishifune C, Kitamura A, Arimochi H, Kataoko K, Chiba S, Shimada M, Yasutomo K
  • Journal Title: Biochem Biophys Res Commun Volume: 418(4) Pages: 701-707
  • URL: http://dx.doi.org/10.1016/j.bbrc.2012.01.082
  • Peer Reviewed
• [Journal Article] Manipulation of CD98 resolves type 1 diabetes in nonobese diabetic mice (2012)
  • Author(s): ian G, Arimochi H, Kitamura A, Nishida J, Li S, Kishihara K, Maekawa Y, Yasutomo K
  • Journal Title: J Immunol Volume: 188 Issue: 5 Pages: 2227-34
  • DOI: 10.4049/jimmunol.1102586
  • Peer Reviewed
• [Journal Article] Notch2 regulates the development of marginal zone B cells through Fos (2012)
  • Author(s): Iwahashi S, et al
  • Journal Title: Biochem Biophys Res Commun Volume: 418号 Pages: 701-707
  • Peer Reviewed
• [Journal Article] Manipulation of CD98 resolves Type 1 diabetes in NOD mice (2012)
  • Author(s): Gaojian L, et al
  • Journal Title: J Immunol Volume: 188号 Pages: 2227-2234
  • Peer Reviewed
• [Journal Article] A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans (2011)
  • Author(s): Kitamura A, Maekawa Y, Uehara H, Izumi K, Kawachi I, Nishizawa M, Toyoshima Y, Takahashi H, Standley DM, Tanaka K, Hamazaki J, Murata S, Obara K, Toyoshima I, Yasutomo K.
  • Journal Title: J Clin Invest Volume: 121 Issue: 10 Pages: 4150-4160
  • DOI: 10.1172/jci58414
  • Peer Reviewed
• [Journal Article] High phosphate diet reduces atherosclerosis formation in apolipoprotein E-deficient mice (2011)
  • Author(s): Shiota A, Taketani Y, Maekawa Y, Yasutomo K, Sata M, Sakai T, Mizuno R, Isshiki M, Yamamoto H, Takeda E
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 49 Issue: 2 Pages: 109-114
  • DOI: 10.3164/jcbn.10-150
  • NAID: 130004466642
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed
• [Journal Article] The Lifestyle of the Segmented Filamentous Bacterium : A Non-Culturable Gut-Associated Immunostimulating Microbe Inferred by Whole-Genome Sequencing (2011)
  • Author(s): Kuwahara T, et al
  • Journal Title: DNA Research Volume: 18 Issue: 4 Pages: 291-303
  • DOI: 10.1093/dnares/dsr022
  • Peer Reviewed
• [Journal Article] Notch signaling regulates the development of a novel type of Thy1-expressing dendritic cell in the thymus (2011)
  • Author(s): Ishifune C, et al
  • Journal Title: Eur J Immunol Volume: 41 Issue: 5 Pages: 1309-20
  • DOI: 10.1002/eji.201041159
  • Peer Reviewed
• [Journal Article] A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans (2011)
  • Author(s): Kitamura A, et al
  • Journal Title: J Clin Invest Volume: 121号 Pages: 4150-4160
  • Peer Reviewed
• [Journal Article] The Lifestyle of the Segmented Filementous Bacterfum : A Non-Culturable Cut-Associated Immunostimulating Mlcrobe Inferred by Whole-Genome Sequencing (2011)
  • Author(s): Kuwahara T, et al
  • Journal Title: DNA Res Volume: 18号 Pages: 291-303
  • Peer Reviewed
• [Journal Article] Notch signaling regulates the development of a novel type of Thy1-expressing dendritic cell in the thymus. (2011)
  • Author(s): Chieko Ishifune
  • Journal Title: European Journal of Immunology Volume: 41 Pages: 1-12
  • Peer Reviewed
• [Journal Article] Notch2 signaling is required for potent anti-tumor immunity in vivo (2010)
  • Author(s): Sugimoto K, Maekawa Y, Kitamura A, Nishida J, Koyanagi A, Yagita H, Kojima H, Chiba S, Shimada M, Yasutomo K
  • Journal Title: J Immunol Volume: 184 Issue: 9 Pages: 4673-4678
  • DOI: 10.4049/jimmunol.0903661
  • Peer Reviewed
• [Journal Article] Notch signaling drives IL-22 secretion in CD4+ T cells by stimulating the aryl hydrocarbon receptor. (2010)
  • Author(s): Alam MS, Maekawa Y, Kitamura A, Tanigaki K, Yoshimoto T, Kishihara K, Yasutomo K
  • Journal Title: Proc Natl Acad Sci USA Volume: 107 Issue: 13 Pages: 5943-5948
  • DOI: 10.1073/pnas.0911755107
  • Peer Reviewed
• [Journal Article] Notch2 signaling is required for potent anti-tumor immunity in vivo. (2010)
  • Author(s): Koji Sugimoto
  • Journal Title: Journal of Immunology 184(Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Notch signaling drives IL-22 secretion in CD4+ T cells by stimulating the aryl hydrocarbon receptor. (2010)
  • Author(s): Muhammad Shamsul Alam
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America 107(13) Pages: 5943-5948
  • Peer Reviewed
• [Journal Article] Protein tyrosine phosphatase-kappa regulates CD4+ T cell development through ERK1/ 2-mediated signaling (2009)
  • Author(s): Erdenebayar N, Maekawa Y, Moshida J, Kitamura A, Yasutomo K
  • Journal Title: Biochem Biophys Res Commun Volume: 390(3) Pages: 489-493
  • URL: http://dx.doi.org/10.1016/j.bbrc.2009.09.117
  • Peer Reviewed
• [Journal Article] Protein-tyrosine phosphatase-kappa regulates CD4+ T cell development through ERK1/2-mediated signaling (2009)
  • Author(s): Namjil Erdenebayar
  • Journal Title: Biochemical and Biophyicals Research Communications 390(3) Pages: 489-493
  • Peer Reviewed
• [Journal Article] High phosphate diet reduces atherosclerosis formation in ApoE-deficient mice
  • Author(s): Asuka Shiota
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: (In Press)
  • Peer Reviewed
• [Presentation] BNotch signaling regulates the development of intraepithelial CD8ττTCRτυcells in the small intestine (2011)
  • Author(s): 前川洋一
  • Organizer: 第40回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ(千葉市)
  • Year and Date: 2011-11-28
• [Presentation] Notch signaling regulates the development of intraepithelial CD8αα TCRαβ cells in the small intestine (2011)
  • Author(s): Yoichi MAEKAWA
  • Organizer: 日本免疫学会
  • Place of Presentation: 幕張メッセ(千葉県)
  • Year and Date: 2011-11-28
• [Presentation] A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans (2011)
  • Author(s): Yoichi MAEKAWA
  • Organizer: 日本免疫学会
  • Place of Presentation: 幕張メッセ(千葉県)
  • Year and Date: 2011-11-27
• [Presentation] Notch2 signaling is required for potent anti-tumor immunity in vivo (2010)
  • Author(s): MAEKAEWA Yoichi
  • Organizer: 第14回国際免疫学会
  • Place of Presentation: 神戸国際会議場(神戸市)
  • Year and Date: 2010-08-23
• [Presentation] NotchシグナルはTリンパ球の恒常性を制御する (2009)
  • Author(s): 前川洋一
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪国際会議場(大阪市)
  • Year and Date: 2009-12-04
• [Presentation] Notch signaling controls T cell homeostasis (2009)
  • Author(s): 前川洋一
  • Organizer: 日本免疫学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-04