| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
To induce not only effector T cells, but also memory T cells is important issue for an establishment of immune defense against infectious and cancer diseases. There are many reports of memory T cells in some viral infectious diseases, however to induce anti-tumor T cell effects against tumor associated antigen has not been studied well, due to the low amounts of antigen expression on tumor cells. We previously demonstrated that our strategy using NKT ligand loaded tumor cells showed long term antitumor effects. In the current study, we analyzed the kinetics of memory T cells and elucidated the mechanism of the induction of memory T cells.
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