Elucidation of the mechanisms in the regulation of type I interferon production in plasmacytoid dendritic cells

• Project/Area Number: 21590547
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Immunology
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: WATARAI Hiroshi 独立行政法人理化学研究所, 免疫制御研究グループ, 上級研究員 (70415339)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 形質細胞様樹状細胞 / インターフェロン / 生体防御 / ウイルス / Toll様受容体 / プレキシン / セマフォリン

Research Abstract

Plasmacytoid dendritic cells(PDC) play a pivotal role in host defense against viruses by their robust production of type I interferons. They exclusively express TLR7 and TLR9 which is a sensor to viral and microbial DNA and RNA, while it has still been unclear in the mechanisms in the augmentation and regulation of cytokine productions. In this research, PDC-TREM, a specific surface receptor on activated PDC surface, has been investigated. PDC-TREM is associated with PlxnA1, a ligand for Sema6D, and gives signals through adaptor molecule DAP12, resulting in the regulation of type I IFN production.

Research Products

• [Journal Article] Development and function of invariant natural killer T cells producing T_H2-and T_H17-cytokines (2012)
  • Author(s): Watarai H, Sekine-Kondo E, Motomura H, Yasuda T, Yoshida H, Kubo M, Koseki H, Taniguchi M.
  • Journal Title: PLoS Biol Volume: 10(2)
  • Peer Reviewed
• [Journal Article] Development and Function of Invariant Natural Killer T cells Producing TH2- and TH17-cytokines (2012)
  • Author(s): Watarai H, Sekine-Kondo E, Shigeura T, Motomura Y, Yasuda T, Satoh R, Yoshida H, Kubo M, Kawamoto H, Koseki H, Taniguchi M
  • Journal Title: PLoS Biol Volume: 10 Issue: 2 Pages: e1001255-e1001255
  • DOI: 10.1371/journal.pbio.1001255
  • Peer Reviewed
• [Journal Article] RCAI-39, 41, 53, 100, 127 and 128, the analogues of KRN7000, activate mouse natural killer T cells to produce Th2-biased cytokines by their administration as liposomal particles (2011)
  • Author(s): Tashiro T, Ishii Y, Shigeura T, Nakagawa R, Watarai H, Taniguchi M, Mori K.
  • Journal Title: Med Chem Comm Volume: 2 Pages: 620-625
  • Peer Reviewed
• [Journal Article] E4bp4, a mammalian basic leucine zipper transcriptinal factor, is a critical regulator of IL-10 and IL-13 production by CD4 T cells (2011)
  • Author(s): Motomura Y, Kitamura H, Hijikata A, Matsunaga Y, Matsumoto K, Inoue H, Atarashi K, Hori S, Watarai H, Zhu J, Taniguchi M, Kubo M.
  • Journal Title: Nat Immunol Volume: 12(5) Pages: 450-459
  • Peer Reviewed
• [Journal Article] The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells (2011)
  • Author(s): Motomura, Y., et al
  • Journal Title: Nature Immunology Volume: 12 Issue: 5 Pages: 450-459
  • DOI: 10.1038/ni.2020
  • Peer Reviewed
• [Journal Article] Synthesis and biological activity of ester and ether analogues ofα-galactosylceramide(KRN7000) (2010)
  • Author(s): Shiozaki M, Tashiro T, Koshino H, Nakagawa R, Inoue S, Shigeura T, Watarai H, Taniguchi M, Mori K.
  • Journal Title: Carbohydr Res Volume: 345(12) Pages: 1663-1684
  • Peer Reviewed
• [Journal Article] Murine induced pluripotent stem cells can be derived from and differentiate into natural killer T cells (2010)
  • Author(s): Watarai H, Fujii SI, Yamada D, Rybouchkin A, Sakata S, Nagata Y, Iida-Kobayashi M, Sekine-Kondo E, Shimizu K, Shozaki Y, Sharif J, Matsuda M, Mochiduki S, Hasegawa T, Kitahara G, Endo T, Toyoda T, Ohara O, Harigaya KI, Koseki H, Taniguchi M.
  • Journal Title: J Clin Invest Volume: 120(7) Pages: 2610-2618
  • Peer Reviewed
• [Journal Article] Induction of Th1-biased cytokine production byα-carba-GalCer, a neoglycolipid ligand for natural killer T cells (2010)
  • Author(s): Tashiro T, Sekine-Kondo E, Shigeura T, Nakagawa R, Inoue S, Omori-Miyake M, Chiba T, Hongo N, Fujii SI, Shimizu K, Mori K, Yoshiga Y, Sumida T, Watarai H, Taniguchi M.
  • Journal Title: Int Immunol Volume: 22(4) Pages: 319-328
  • Peer Reviewed
• [Journal Article] Regulation of IL-9 expression by IL-25 signaling (2010)
  • Author(s): Angkasekwinai P, Chang SH, Thapa M, Watarai H, Dong C.
  • Journal Title: Nat Immunol Volume: 11(3) Pages: 250-256
  • Peer Reviewed
• [Journal Article] High-mobility group box 1 is involved in the initial events of early loss of transplanted islets in mice (2010)
  • Author(s): Matsuoka N, Itoh T, Watarai H, Sekine-Kondo E, Nagata N, Okamoto K, Mera T, Yamamoto H, Yamada S, Maruyama I, Taniguchi M, Yasunami Y.
  • Journal Title: J Clin Invest Volume: 120(3) Pages: 735-743
  • NAID: 120002142757
  • Peer Reviewed
• [Journal Article] Generation of functional NKT cells in vitro from embryonic stem cells bearing rearranged invariant Vα14-Jα18 TCRαgene (2010)
  • Author(s): Watarai H, Rybouchkin A, Hongo N, Nagata Y, Sakata S, Sekine E, Dashtsoodol N, Tashiro T, Fujii SI, Shimizu K, Mori K, Masuda K, Kawamoto H, Koseki H, Taniguchi M.
  • Journal Title: Blood Volume: 115(2) Pages: 230-237
  • Peer Reviewed
• [Journal Article] The specialized iNKT cell system recognizes glycolipid antigens and bridges the innate and acquired immune systems with potential applications for cancer therapy (2010)
  • Author(s): Taniguchi M, Tashiro T, Dashtsoodol N, Hongo N, Watarai H.
  • Journal Title: Int Immunol Volume: 22(1) Pages: 1-6
  • NAID: 10027390882
  • Peer Reviewed
• [Journal Article] Induction of Th1-biased cytokine production by □-carba-GalCer, a neogly colipid ligand for NKT cells. (2010)
  • Author(s): Tashiro T, et al.
  • Journal Title: Int Immunol Volume: 22 Pages: 319-328
  • Peer Reviewed
• [Journal Article] Murine induced pluripotent stem cells can be derived from and differentiate into natural killer T cells. (2010)
  • Author(s): Watarai H, et al.
  • Journal Title: J Clin Invest Volume: 120 Pages: 2610-2618
  • Peer Reviewed
• [Journal Article] Synthesis and biological activity of ester and ether analogues of α-galactosylceramide (KRN7000). (2010)
  • Author(s): Shiozaki M, et al
  • Journal Title: Carbohydr Res Volume: 345 Pages: 1663-1684
  • Peer Reviewed
• [Journal Article] The specialized iNKT cell system recognizes glycolipid antigens and bridges the innate and acquired immune systems with potential applications for cancer therapy (2010)
  • Author(s): Taniguchi M, et al.
  • Journal Title: International Immunology 22 Pages: 1-6
  • Peer Reviewed
• [Journal Article] Generation of functional NKT cells in vitro from embryonic stem cells bearing rearranged invariant V{alpha}14-J{alpha}18 TCR{alpha}gene (2010)
  • Author(s): Watarai H, Rybouchkin A, Hongo N, et al.
  • Journal Title: Blood 115 Pages: 230-237
  • Peer Reviewed
• [Journal Article] High-mobility group box 1 is involved in the initial events of early loss of transplanted islets in mice (2010)
  • Author(s): Matsuoka N, Itoh T, Watarai H, et al.
  • Journal Title: Journal of Clinical Investigation 120(in press)
  • NAID: 120002142757
  • Peer Reviewed
• [Journal Article] Regulation of IL-9 expression by IL-25 signaling (2010)
  • Author(s): Angkasekwinai P, et al.
  • Journal Title: Nature Immunology 11 Pages: 250-256
  • Peer Reviewed
• [Journal Article] M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex (2009)
  • Author(s): Hase K, Kimura S, Takatsu H, Ohmae M, Kawano S, Kitamura H, Ito M, Watarai H, Hazelett CC, Yeaman C, Ohno H.
  • Journal Title: Nat Cell Biol Volume: 11(12) Pages: 1427-1432
  • Peer Reviewed
• [Journal Article] RCAI-37, 56, 59, 60, 92, 101, and 102, cyclitol and carbasugar analogs of KRN7000 : their synthesis and bioactivity for mouse lymphocytes to produce Th1-biased cytokines (2009)
  • Author(s): Tashiro T, Nakagawa R, Hirokawa T, Inoue S, Watarai H, Taniguchi M, Mori K.
  • Journal Title: Bioorgan Med Chem Volume: 17(17) Pages: 6360-6373
  • Peer Reviewed
• [Journal Article] RCAI-37, 56, 59, 60, 92, 101, and 102, cyclitol and carbasugar analogs of KRN7000 : their synthesis and bioactivity for mouse lymphocytes to produce Th1-biased cytokines (2009)
  • Author(s): Tashiro T, et al.
  • Journal Title: Bioorganic & Medicinal Chemistry 17 Pages: 6360-6373
  • Peer Reviewed
• [Journal Article] M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex (2009)
  • Author(s): Hase K, et al.
  • Journal Title: Nature Cell Biology 11 Pages: 1427-1432
  • Peer Reviewed
• [Presentation] Development and function of invariant natural killer T cells producing T_H2-and T_H17-cytokines (2012)
  • Author(s): Watarai H, Sekine-Kondo E, Taniguchi M.
  • Organizer: Keystone Symposia : The Biology of Cytokines/Th17 Cells in Health and Disease
  • Place of Presentation: Keystone, USA
  • Year and Date: 2012-02-08
• [Presentation] Development and Function of Inflammatory NKT cells (2012)
  • Author(s): 渡会浩志、近藤悦子、谷口克
  • Organizer: Keystone Symposia : The Biology of Cytokines/Th17 Cells in Health and Disease
  • Place of Presentation: キーストーン(米国)
  • Year and Date: 2012-02-07
• [Presentation] Development of Inflammatory natural killer T cells in the Thymus (2011)
  • Author(s): 渡会浩志、近藤悦子、谷口克
  • Organizer: 第40回日本免疫学会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2011-12-06
• [Presentation] 気道過敏性発症に関与する炎症性ナチュラルキラーT細胞の機能と分化 (2011)
  • Author(s): 渡会浩志
  • Organizer: 第48回日本小児アレルギー学会・第16回アジア太平洋小児アレルギー呼吸器免疫学会合同学術大会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2011-10-28
• [Presentation] Function of Pathogenic Invariant Natural Killer T Cells Contribute to the Induction of Airway Hyperreactivity (2011)
  • Author(s): 渡会浩志
  • Organizer: APAPARI 2011 & 48^<th> JSPACI
  • Place of Presentation: 福岡国際会議場(福岡)
  • Year and Date: 2011-10-28
• [Presentation] Development and Function of TH2- and TH17-Cytokine Producing NKT cells (2011)
  • Author(s): 渡会浩志
  • Organizer: 6^<th> International Symposium on CD1 and NKT Cells
  • Place of Presentation: シカゴ(米国)
  • Year and Date: 2011-09-27
• [Presentation] Development and function of invariant natural killer T cells producing T_H2-and T_H17-cytokines (2011)
  • Author(s): Watarai H, Sekine-Kondo E, Taniguchi M.
  • Organizer: 6^<th> International Symposium on CD1 and NKT cells
  • Place of Presentation: Chicago, USA
  • Year and Date: 2011-09-24
• [Presentation] ナチュラルキラーT(NKT)細胞による気道過敏症発症と炎症慢性化機構 (2011)
  • Author(s): 渡会浩志
  • Organizer: 第3回小児気道アレルギーフォーラム
  • Place of Presentation: ホテルニューオータニ博多
  • Year and Date: 2011-05-21
• [Presentation] Reprogramming of natural killer T(NKT) cells to induced pluripotent stem cells and their development into functional NKT cells in vitro (2010)
  • Author(s): Watarai H, Fujii S, Yamada D, Rybouchkin A, Sakata S, Nagata Y, Iida-Kobayashi M, Sekine-Kondo E, Shimizu K, Endo TA, Toyoda T, Ohara O, Koseki H, Taniguchi M.
  • Organizer: 16^<th> International Conference of the International Society of Differentiation
  • Place of Presentation: Nara, Japan
  • Year and Date: 2010-11-16
• [Presentation] iPS cell derived natural killer T (NKT) cells. (2010)
  • Author(s): Watarai H, et al
  • Organizer: 16^<th> International Conference of the International Society of Differentiation
  • Place of Presentation: Nara, Japan
  • Year and Date: 2010-11-16
• [Presentation] Murine induced pluripotent stem cells can be derived from and differentiate into natural killer T cells (2010)
  • Author(s): Watarai H, et al
  • Organizer: 11^<th> International Symposium on Dendritic Cells
  • Place of Presentation: Lugano, Switzerland
  • Year and Date: 2010-09-28
• [Presentation] Murine induced pluripotent stem cells can be derived from and differentiate into natural killer T cells (2010)
  • Author(s): Watarai H, Fujii S, Koseki H, Taniguchi M.
  • Organizer: 11^<th> International Symposium on Dendritic Cells : Forum on Vaccine Science
  • Place of Presentation: Lugano, Switzer
  • Year and Date: 2010-09-27
• [Presentation] iPS cell-derived natural killer T cells (2010)
  • Author(s): 渡会浩志
  • Organizer: 第2回Meet the Expert
  • Place of Presentation: 広島大学
  • Year and Date: 2010-09-15
• [Presentation] Therapeutic potential of natural killer T cells derived from iPS cells (2010)
  • Author(s): 渡会浩志
  • Organizer: 第15回神経芽腫研究会
  • Place of Presentation: 国立がんセンター
  • Year and Date: 2010-08-28
• [Presentation] Reprogramming of natural killer T(NKT) cells to induced pluripotent stem cells and their development into functional NKT cells in vitro (2010)
  • Author(s): Watarai H, Fujii S, Yamada D, Rybouchkin A, Sakata S, Nagata Y, Iida-Kobayashi M, Sekine-Kondo E, Shimizu K, Endo TA, Toyoda T, Ohara O, Koseki H, Taniguchi M.
  • Organizer: 14^<th> International Congress on Immunology
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2010-08-23
• [Presentation] Reprogramming of natural killer T (NKT) cells to induced pluripotent stem cells and their development into functional NKT cells in vitro (2010)
  • Author(s): Watarai H, et al
  • Organizer: 14^<th> International Congress on Immunology
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2010-08-23
• [Presentation] 気道過敏症発症に関与する新しい細胞集団の発見 (2009)
  • Author(s): 渡会浩志
  • Organizer: 第12回小児吸入療法フォーラム
  • Place of Presentation: ベルサール神田
  • Year and Date: 2009-11-21
• [Presentation] A novel subset of mouse NKT cells bearing the IL-17 receptor Bresponds to IL-25 and contributes to airway hyperreactivity (2009)
  • Author(s): 渡会浩志, ら
  • Organizer: 第21回日本アレルギー学会春季臨床大会
  • Place of Presentation: 長良川国際会議場(岐阜)
  • Year and Date: 2009-06-06
• [Book] 気道過敏性発症に関与する炎症性NKT細胞サブセットの機能と胸腺内分化、炎症と免疫 (2012)
  • Author(s): 渡会浩志
  • Publisher: 先端医学社
• [Book] 「炎症と免疫」気道過敏性発症に関与する炎症性NKT細胞サブセットの機能と胸腺内分化 (2012)
  • Author(s): 渡会浩志
  • Publisher: 先端医学社
• [Book] NKT細胞、「免疫疾患」 (2011)
  • Author(s): 渡会浩志・谷口克
  • Publisher: エル・アイ・シー
• [Book] Mechanisms of NKT-cell-mediated adjuvant activity and function of iPS-derived NKT cells, Natural Killer T cells : Balancing the Regulation of Tumor Immunity (2011)
  • Author(s): Taniguchi M, Fujii S, Nakayama T, Motohashi S, Dashtsoodol N, Watarai H, Harada M.
  • Publisher: Springer
• [Book] A role for natural killer T-cell subsets in the pathogenesis of various allergic disordersn, Inflammation and Allergy Drug Desig (2011)
  • Author(s): Watarai H, Harada M, Tamari M, Taniguchi M.
• [Book] 抗腫瘍効果を発揮する免疫担当細胞NKT細胞のiPS細胞からの分化誘導、生物の科学遺伝 (2011)
  • Author(s): 渡会浩志・谷口克
  • Publisher: エヌ・ティー・エス
• [Book] 免疫疾患-疾患モデルの作製と利用-NKT細胞 (2011)
  • Author(s): 渡会浩志・谷口克
  • Publisher: エル・アイ・シー
• [Book] Natural Killer T cells : Balancing the Regulation of Tumor Immunity NKT-cell-mediated adjuvant activity and function of iPS-derived NKT cells (2011)
  • Author(s): Taniguchi M, Fujii S, Nakayama T, Motohashi S, Dashtsoodol N, Watarai H, Harada M
  • Publisher: Springer
• [Book] Inflammation and Allergy Drug Design A role for natural killer T-cell subsets in the pathogenesis of various allergic disorders (2011)
  • Author(s): Watarai H, Harada M, Tamari M, Taniguchi M.
  • Publisher: Wiley Blackwell
• [Book] 「生物の科学遺伝」抗腫瘍効果を発揮する免疫担当細胞NKT細胞のiPS細胞からの分化誘導 (2011)
  • Author(s): 渡会浩志・谷口克
  • Publisher: エヌ・ティー・エス
• [Book] 糖脂質リガンドの相違によるNKT細胞のサイトカイン産生、臨床免疫・アレルギー科 (2010)
  • Author(s): 渡会浩志・田代卓哉・谷口克
  • Publisher: 科学評論社
• [Book] IL-17レセプターB陽性NKT細胞によるアレルギーの誘導、臨床免疫・アレルギー科 (2010)
  • Author(s): 渡会浩志・谷口克
  • Publisher: 科学評論社
• [Book] ナチュラルキラーT細胞の発生と分化、医学のあゆみ (2010)
  • Author(s): 渡会浩志・谷口克
  • Publisher: 医歯薬出版株式会社
• [Book] ナチュラルキラーT細胞の発生と分化 (2010)
  • Author(s): 渡会浩志・谷口克
  • Publisher: 医歯薬出版株式会社「医学のあゆみ」
• [Book] 糖脂質リガンドの相違によるNKT細胞のサイトカイン産生 (2010)
  • Author(s): 渡会浩志・田代卓哉・谷口克
  • Publisher: 科学評論社「臨床免疫・アレルギー科」
• [Book] IL-25によるNKT細胞のサイトカイン産生、臨床免疫・アレルギー科 (2009)
  • Author(s): 渡会浩志・谷口克
  • Publisher: 科学評論社
• [Book] アレルギー性喘息など気道過敏性を引き起こす細胞の発見、日本農芸化学会会誌『化学と生物』 (2009)
  • Author(s): 渡会浩志
• [Book] IL-17RB+NKT細胞による喘息誘導、感染炎症免疫 (2009)
  • Author(s): 渡会浩志・谷口克
  • Publisher: 医薬の門社
• [Book] NKT細胞による免疫制御機構とアレルギー発症のメカニズム、実験医学増刊・アレルギー疾患の免疫機構 (2009)
  • Author(s): 渡会浩志・谷口克
  • Publisher: 羊土社
• [Book] アレルギー性ぜんそくとNKT細胞、メディカル・サイエンス・ダイジェスト (2009)
  • Author(s): 渡会浩志・谷口克
  • Publisher: ニューサイエンス社
• [Remarks]
  • URL: http://www.riken.jp/r-world/research/lab/rcai/regulation/index.html
• [Remarks]
  • URL: http://web.rcai.riken.jp/en/labo/regulation/
• [Remarks]
  • URL: http://www.riken.jp/r-world/research/lab/rcai/regulation/index.html
• [Remarks]
  • URL: http://web.rcai.riken.jp/en/labo/regulation/
• [Patent(Industrial Property Rights)] iPS細胞由来アロNKT細胞を用いた免疫療法およびそのためのNKT細胞由来iPS細胞および該iPS由来NKT細胞のバンキング (2011)
  • Inventor(s): 谷口克、渡会浩志、古関明彦、藤井眞一郎
  • Industrial Property Rights Holder: 独立行政法人理化学研究所
  • Acquisition Date: 2011-12-02
  • Overseas
• [Patent(Industrial Property Rights)] 非アレルギー性気道炎症及び/または非アレルギー性気道過敏症の治療薬 (2011)
  • Inventor(s): 渡会浩志、谷口克
  • Industrial Property Rights Holder: 独立行政法人理化学研究所
  • Acquisition Date: 2011-10-31
  • Overseas
• [Patent(Industrial Property Rights)] 非アレルギー性気道炎症及び/または非アレルギー性気道過敏症の治療薬 (2011)
  • Inventor(s): 渡会浩志、谷口克
  • Industrial Property Rights Holder: 独立行政法人理化学研究所
  • Filing Date: 2011-10-31
  • Overseas
• [Patent(Industrial Property Rights)] iPS細胞由来アロNKT細胞を用いた免疫療法及びそのためのiPS細胞バンキング (2011)
  • Inventor(s): 谷口克、古関明彦、渡会浩志、藤井眞一郎
  • Industrial Property Rights Holder: 独立行政法人理化学研究所
  • Filing Date: 2011-12-02
  • Overseas
• [Patent(Industrial Property Rights)] 新規合成糖脂質およびその用途 (2010)
  • Inventor(s): 田代卓哉、森謙治、汐崎正生、谷口克、渡会浩志、重浦智邦
  • Industrial Property Rights Holder: 独立行政法人理化学研究所
  • Acquisition Date: 2010-02-05
• [Patent(Industrial Property Rights)] iPS細胞由来アロNKT細胞を用いた免疫療法およびそのためのNKT細胞由来iPS細胞および該iPS由来NKT細胞のバンキング (2010)
  • Inventor(s): 渡会浩志、藤井眞一郎、古関明彦、谷口克
  • Industrial Property Rights Holder: 独立行政法人理化学研究所
  • Filing Date: 2010-12-02
  • Overseas
• [Patent(Industrial Property Rights)] 新規合成糖脂質およびその用途 (2010)
  • Inventor(s): 田代卓哉、森謙治、汐崎正生、谷口克、渡会浩志
  • Industrial Property Rights Holder: 理化学研究所
  • Industrial Property Number: 2010-024859
  • Filing Date: 2010-02-05
• [Patent(Industrial Property Rights)] エステル化α-ガラクトシルセラミド類 (2009)
  • Inventor(s): 汐崎正生、田代卓哉、森謙治、中川竜介、渡会浩志、谷口克、鈴木小夜
  • Industrial Property Rights Holder: 独立行政法人理化学研究所
  • Acquisition Date: 2009-09-11
  • Overseas
• [Patent(Industrial Property Rights)] NKT細胞由来iPS細胞およびそれ由来のNKT細胞 (2009)
  • Inventor(s): 谷口克、渡会浩志、古関明彦、藤井眞一郎、小林美登里、坂田さくら、長田夕子
  • Industrial Property Rights Holder: 独立行政法人理化学研究所
  • Acquisition Date: 2009-09-08
  • Overseas
• [Patent(Industrial Property Rights)] B細胞由来iPS細胞およびその用途 (2009)
  • Inventor(s): 谷口克、渡会浩志、伊川友活、石川文彦、河本宏、古関明彦、小林美登里
  • Industrial Property Rights Holder: 独立行政法人理化学研究所
  • Acquisition Date: 2009-09-04
  • Overseas
• [Patent(Industrial Property Rights)] NKT細胞由来iPS細胞およびそれ由来のNKT細胞 (2009)
  • Inventor(s): 谷口克、渡会浩志、古関明彦、藤井眞一郎
  • Industrial Property Rights Holder: 理化学研究所
  • Filing Date: 2009-09-08
  • Overseas