Effect of a novel resistance associated mutation, N348I, which has been identified in Japanese HIV-1 infected patients, on the reverse transcriptase activity.
Project/Area Number |
21590591
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Applied pharmacology
|
Research Institution | Tohoku University |
Principal Investigator |
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | ウイルス / HIV / 薬剤耐性 / 逆転写酵素 / 多剤耐性 / 臨床分離株 |
Research Abstract |
Effect of a novel resistance associated mutation, N348I, which has been identified in Japanese HIV-1 infected patients, on the reverse transcriptase activity.
|
Report
(4 results)
Research Products
(67 results)
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[Journal Article] Biochemical, inhibition, and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase2012
Author(s)
Tanyaradzwa P. Ndongwe, Adeyemi O. Adedeji, Eleftherios Michailidis, Yee Tsuey Ong, Atsuko Hachiya, Bruno Marchand, Emily M. Ryan, Devendra K. Rai, Karen A. Kirby, Angela S. Whatley, Donald H. Burke, Marc Johnson, Shilei Ding, Yi-Min Zheng, Shan-Lu Liu, E
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[Journal Article] Affinity selection and sequence-activity relationships of HIV-1 membrane fusion inhibitors directed at the drug-resistant variants2010
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Shinya Oishi, Kentaro Watanabe, Saori Ito, Michinori Tanaka, Hiroki Nishikawa, Hiroaki Ohno, Kazuki Shimane, Kazuki Izumi, Yasuko Sakagami, Eiichi N. Kodama, Masao Matsuoka, Akira Asai and Nobutaka Fujii
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[Journal Article] Rev-derived peptides inhibit HIV-1 replication by antagonism of Rev and a co-receptor, CXCR42010
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Kazuki Shimane, Eiichi N. Kodama, Ikuhiko Nakase, Shiroh Futaki, Yasuteru Sakurai, Yasuko Sakagami, Xiaoguang Li, Toshio Hattori, Stefan G. Sarafianos, Masao Matsuoka
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[Journal Article] Characterization of HIV-1 resistance to a fusion inhibitor, N36, derived from the gp41 amino terminal heptad repeat2010
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Kazuki Izumi, Shota Nakamura, Hiroaki Nakano, Kazuya Shimura, Yasuko Sakagami, Shinya Oishi, Susumu Uchiyama, Tadayasu Ohkubo, Yuji Kobayashi, Nobutaka Fujii, Masao Matsuoka, Eiichi N. Kodama
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[Journal Article] Synthesis and Biological Evaluation of Selective CXCR4 Antagonists Containing Alkene Dipeptide Isosteres2010
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Tetsuo Narumi, Ryoko Hayashi, Kenji Tomita, Kazuya Kobayashi, Noriko Tanahara, Hiroaki Ohno, Takeshi Naito, Eiichi Kodama, Masao Matsuoka, Shinya Oishi, and Nobutaka Fujii
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[Journal Article] Synthesis and Biological Evaluatian of Selective CXCR4 Antagonists Containing Alkene Dipeptide Isosteres.2010
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Tetsuo Narumi, Ryoko Hayashi, Kenji Tomita, Kazuya Kobayashi, Noriko Tanahara, Hiroaki Ohno, Takeshi Naito, Eiichi Kodama, Masao Matsuoka, Shinya Oishi, Nobutaka Fujii
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Journal Title
Organic & Biomolecular Chemistry
Volume: 8
Pages: 616-621
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[Journal Article] Characterization of HIV-1 resistance to a fusion inhibitor, N36, derived from the gp41 amino terminal heptad repeat.2010
Author(s)
Kazuki Izumi, Shota Nakamura, Hiroaki Nakano, Kazuya Shimura, Yasuko Sakagami, Shinya Oishi, Susumu Uchiyama, Tadayasu Ohkubo, Yuji Kobayashi, Nobutaka Fujii, Masao Matsuoka, Eiichi N.Kodama
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Journal Title
Antiviral Research
Volume: 87
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[Journal Article] Rev-derived peptides inhibit HIV 1 replication by antagonism of Rev and a co-receptor, CXCR4.2010
Author(s)
Kazuki Shimane, Eiichi N.Kodama, Ikuhiko Nakase, Shiroh Futaki, Yasuteru Sakurai, Yasuko Sakagami, Xiaoguang Li, Toshio Hattori, Stefan G.Sarafianos,Masao Matsuoka
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Journal Title
Internatianal Journal of Biochemistry and Cell Biology
Volume: 42
Pages: 1482-1488
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[Journal Article] Affinity selection and sequence-activity relationships of HIV-1 membrane fusion inhibitors directed at the drug-resistant variants.2010
Author(s)
Shinya Oishi, Kentaro Watanabe, Saori Ito, Michinori Tanaka, Hiroki Nishikawa, Hiroaki Ohno, Kazuki Shimane, Kazuki Izumi, Yasuko Sakagami, Eiichi N.Kodama, Masao Matsuoka, Akira Asai, Nobutaka Fujii
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Journal Title
Medicinal Chemistry Communications
Volume: 1
Pages: 276-281
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[Journal Article] Synthesis and Biological Evaluation of Selective CXCR4 Antagonists Containing Alkene Dipeptide Isosteres.2010
Author(s)
Tetsuo Narumi, Ryoko Hayashi, Kenji Tomita, Kazuya Kobayashi, Noriko Tanahara, Hiroaki Ohno, Takeshi Naito, Eiichi Kodama, Masao Matsuoka, Shinya Oishi, Nobutaka Fujii.
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Organic & Biomolecular Chemistry 8
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[Journal Article]2010
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児玉栄一, 他
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[Journal Article] Mechanism of inhibition of HIV-1 reverse transcriptase by 4'-ethynyl-2-fluoro-2'-doxyadenosine triphosphate, a translocation defective reverse transcriptase inhibitor2009
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Journal Title
Journal of Biological Chemistry
Volume: 284
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[Journal Article] Bioorganic Synthesis of a Recombinant HIV-1 Fusion Inhibitor, SC35EK, with an N-Terminal Pyroglutamate Capping Group2009
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Kazumi Kajiwara, Kentaro Watanabe, Rei Tokiwa, Tomoko Kurose, Hiroaki Ohno, Hiroko Tsutsumi, Yoji Hata, Kazuki Izumi, Eiichi Kodama, Masao Matsuoka, Shinya Oishi, and Nobutaka Fujii
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[Journal Article] Bioorganic Synthesis of End-capped Anti-HIV Peptides by Simultaneous Cyanocysteine-mediated Cleavages of Recombinant Proteins2009
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[Journal Article] X-ray Crystallographic Study of an HIV-1 Fusion Inhibitor with the gp41 S138A Substitution2009
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[Journal Article] Design and synthesis of membrane fusion inhibitors against the feline immunodeficiency virus2009
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[Journal Article] Peptide bond mimicry by(E)-alkene and(Z)-fluoroalkene peptide isosteres : synthesis and bioevaluation of alpha-helical anti-HIV peptide analogues2009
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Shinya Oishi, Hirotaka Kamitani, Yasuyo Kodera, KentaroWatanabe, Kazuya Kobayashi, Tetsuo Narumi, Kenji Tomita, Hiroaki Ohno, Takeshi Naito, Eiichi Kodama, Masao Matsuoka and Nobutaka Fujii
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[Journal Article] Clinical relevance of substitutions in the connection subdomain and RNase H domains of HIV-1 reverse transcriptase from a cohort of antiretroviral treatment-naive patients2009
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[Journal Article] Electrostatically constrained α-helical peptide inhibits replication of HIV-1 resistant to enfuvirtide.2009
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[Journal Article] Clinical relevance of substitutions in the connection subdomain and R Nase H domains of HIV-1 reverse transcriptase from a cohort of antiretroviral treatment-naive patients.2009
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[Journal Article] Peptide bond mimicry by (E)-alkene and (Z)-fluoroalkene peptide isosteres : synthesis and bioevaluation of alpha-helical anti-HIV peptide analogues.2009
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[Journal Article] Design and synthesis of membrane fusion inhibitors against the feline immunodeficiency virus.2009
Author(s)
Shinya Oishi, Yasuyo Kodera, Hiroki Nishikawa, Kamitani H, Tsuyoshi Watabe, Hiroaki Ohno, Tadafumi Tochikura, Kazuki Shimane, Eiichi Kodama, Masao Matsuoka, Fuminori Mizukoshi, Hajime Tsujimoto H, Nobutaka Fujii
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[Journal Article] X-ray Crystallographic Study of an HIV-1 Fusion Inhibitor with the gp41 S138A Substitution.2009
Author(s)
Tsuyoshi Watabe, Yukihiro Terakawa, Kentaro Watanabe, Hiroaki Ohno, Hiroaki Nakano, Toru Nakatsu, Hiroaki Kato, Kazuki Izumi, Eiichi Kodama, Masao Matsuoka, Kazuo Kitaura, Shinya Oishi, Nobutaka Fujii.
-
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Journal of Molecular Biology 392
Pages: 657-665
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-
[Journal Article] Bioorganic Synthesis of End-capped Anti-HIV Peptides by Simultaneous Cyanocysteine-mediated Cleavages of Recombinant Proteins.2009
Author(s)
Michinori Tanaka, Kazumi Kajiwara, Rei Tokiwa, Kentaro Watanabe, Hiroaki Ohno, Hiroko Tsutsumi, Yoji Hata, Kazuki Izumi, Eiichi Kodama, Masao Matsuoka, Shinya Oishi, Nobutaka Fujii
-
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Bioorganic & Medicinal Chemistry 17
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-
[Journal Article] Bioorganic Synthesis of a Recombinant HIV-1 Fusion Inhibitor, SC35EK, with an N-Terminal Pyroglutamate Capping Group.2009
Author(s)
Kazumi Kajiwara, Kentaro Watanabe, Rei Tokiwa, Tomoko Kurose, Hiroaki Ohno, Hiroko Tsutsumi, Yoji Hata, Kazuki Izumi, Eiichi Kodama, Masao Matsuoka, Shinya Oishi, Nobutaka Fujii.
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[Journal Article] Mechanism of inhibition of HIV-1 reverse transcriptase by 4'-ethynyl-2-fluoro-2'-doxyadenosine triphosphate, a translocation defective reverse transcriptase inhibitor.2009
Author(s)
Eleftherios Michailidis, Bruno Marchand, Eiichi N.Kodama, Kamlendra Singh, Masao Matsuoka, Karen A.Kirby, Emily M.Ryan, Ali M.Sawani, Eva Nagy, Noriyuki Ashida, Hiroaki Mitsuya, Michael A.Parniak, Stefan G.Sarafianos.
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Journal Title
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[Journal Article]2009
Author(s)
児玉栄一、服部俊夫, 他
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Pages: 2754-2761
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[Presentation] Effect of 4'-and2-NRTI Substitutions on the Inhibition Mechanism of HIV Reverse Transcriptase2011
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Organizer
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Place of Presentation
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[Presentation] HIV-1 Reverse Transcriptase(RT)Polymorphism 172K Suppresses the Effect of Clinically Relevant Drug Resistance Mutations to Both Nucleoside and Nonnucleoside RT Inhibitors2011
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Organizer
12th Annual Symposium on Antiviral Drug Resistance, Hershey, Pennsylvania
Place of Presentation
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[Presentation] HIV-1 Reverse Transcriptase (RT) Polymorphism 172K Suppresses the Effeet of Clinically Relevant Drug Resistance Mutations to Both Nucleoside and Nonnucleoside RT Inhibitors2011
Author(s)
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Organizer
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Place of Presentation
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[Presentation] Effect of 4'- and 2-NRTI Substitutions on the Inhibition Mechanism of HIV Reverse Transcriptase2011
Author(s)
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Organizer
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Place of Presentation
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[Presentation] The NNRTI-resistant Y181C HIV-1 reverse transcriptase is hyper-susceptible to 4'-ethynyl-2-fluoro deoxyadenosine(EFDA)2009
Author(s)
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Organizer
10th Annual Symposium on Antiviral Drug Resistance
Place of Presentation
アメリカ、リッチモンド
Year and Date
2009-11-16
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[Presentation] K70Q expands multi-drug resistance(MDR)of HIV-1 containing"Q151M complex" reverse transcriptase mutations2009
Author(s)
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Organizer
10th Annual Symposium on Antiviral Drug Resistance, Richmond, VA
Place of Presentation
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[Presentation] The NNRTI-resistant Y181C HIV-1 reverse transcriptase is hyper-susceptible to 4'-ethynyl-2-fluoro deoxyadenosine(EFDA)2009
Author(s)
Yee Tsuey Ong, Eleftherios Michailidis, Bruno Marchand, Matthew S. Schuckmann, Kamlendra Singh, Ei-Ichi Kodama, Masao Matsuoka, Hiroaki Mitsuya, Eva Nagy, Michael A. Parniak, and Stefan G. Sarafianos
Organizer
10th Annual Symposium on Antiviral Drug Resistance, Richmond, VA
Place of Presentation
USA
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[Presentation] Biochemical characterization of the HIV reverse transcriptase connection domain multi-class drug resistance mutation N348I2009
Author(s)
Matthew Schuckmann, Atsuko Hachiya, Ei-ichi N. Kodama, Bruno Marchand, Eleftherios Michailidis, Kamlendra Singh, Yasuko Sakagami, Shinichi Oka, and Stefan G. Sarafianos
Organizer
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Place of Presentation
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