Optimization of antifungal regimens based on site-specific pharmacokinetics-pharmacodynamics-pharmacogenomics
| Project/Area Number |
21590595
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Hiroshima University |
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Principal Investigator |
IKAWA Kazuro 広島大学, 大学院・医歯薬学総合研究科, 准教授 (40363048)
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| Co-Investigator(Kenkyū-buntansha) |
MORIKAWA Norifumi 広島大学, 大学院・医歯薬学総合研究科, 教授 (30346481)
IKEDA Kayo 広島大学, 大学院・医歯薬学総合研究科, 助教 (30379911)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | 臨床 / 感染症 / 薬物動態 / 薬力学 |
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| Research Abstract |
The present research established simple and rapid systems to determine drug concentrations for azole and candin antifungals. The research performed pharmacokinetic analyses of drug concentration data, which were obtained by measuring concentrations in plasma and biological fluids, at the target sites, of patients. Then, the research examined the relationship between pharmacokinetics and pharmaco dynamics by incorporating pharmacogenomic data(wild type, mutant heterozygous or homozygous mutant of P450) as covariates. By Monte Carlo simulation with this modeling, the research investigated the optimal antifungal regimens. Also, the research developed software technology that healthcare professionals can design the optimal antifungal regimens based on information about the patient and causative bacteria.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Safety analysis of liposomal amphotericin B in adult patients : anaemia, thrombocytopenia, nephrotoxicity, hepatotoxicity and hypokalaemia2011
Author(s)
Shigemi A, Matsumoto K, Ikawa K, YajiK, Shimodozono Y, Morikawa N, TakedaY, Yamada K.
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Journal Title
Int. J. Antimicrob. Agents
Volume: 38
Pages: 417-420
Related Report
Peer Reviewed
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[Journal Article] Safety analysis of liposomal amphotericin B in adult patients : anaemia, thrombocytopenia, nephrotoxicity, hepatotoxicity and hypokalaemia2011
Author(s)
Shigemi A, Matsumoto K, Ikawa K, Yaji K, Shimodozono Y, Morikawa N, Takeda Y, Yamada K
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Journal Title
Int.J.Antimicrob.Agents.
Volume: 38
Pages: 417-420
Related Report
Peer Reviewed
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[Presentation] Dexamethasone reduced voricona zoleplasma level in a patient who carries CYP2C19 mutant2009
Author(s)
Matsumoto K, Kondo T, Kanazawa N, Yokoyama Y, Fukamizu T, Takeda Y, Mukai M, Arimura H, Nakazaki M, IkawaK, Morikawa N, Tei C, Yamada K.
Organizer
Asian Federation for Pharmaceutical Sciences 2009
Place of Presentation
Fukuoka, Japan
Year and Date
2009-10-16
Related Report
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[Presentation] Dexamethasone reduced voriconazole plasma level in a patient who carries CYP2C19 mutant2009
Author(s)
Matsumoto K, Kondo T, Kanazawa N, Yokoyama Y, Fukamizu T, Takeda Y, Mukai M, Arimura H, Nakazaki M, Ikawa K, et al.
Organizer
Asian Federation for Pharmaceutical Sciences
Place of Presentation
Fukuoka, Japan
Year and Date
2009-10-16
Related Report
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