Association Study of Closed-angle Glaucoma

• Project/Area Number: 21590596
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied pharmacology
• Research Institution: Nagasaki University
• Principal Investigator: KONDO Shinji 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (90398149)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: ファーマコゲノミクス / 緑内障 / 遺伝子 / 関連解析 / 相関解析

Research Abstract

We performed a Single Nucleotide Polymorphism-based association study in 41 closed-angle glaucoma cases and 100 healthy controls. Although 16 genes were investigated to see whether these genes are responsible for this disease or not, we were unable to detect any novel variants for closed-angle glaucoma risk in these genes.

Research Products

• [Journal Article] PBC Study Group in NHOSLJ. A polymorphism in the integrinαV subunit gene affects the progression of primary biliary cirrhosis in Japanese patients (2011)
  • Author(s): Inamine T, Nakamura M, Kawauchi A, Shirakawa Y, Hashiguchi H, Aiba Y, Taketomi A, Shirabe K, Nakamuta M, Hayashi S, Saoshiro T, Komori A, Yatsuhashi H, Kondo S, Omagari K, Maehara Y, Ishibashi H, Tsukamoto K
  • Journal Title: J Gastroenterol Volume: 46(5) Pages: 676-86
  • Peer Reviewed
• [Journal Article] The evidence of polymorphisms of the liver X receptor gene as a DNA-based biomarker for susceptibility to coronary artery disease in a Japanese population (2011)
  • Author(s): Fukae A et al(10人中6番目)
  • Journal Title: Acta Medica Nagasakiensia Volume: 55(2) Pages: 69-76
  • Peer Reviewed
• [Journal Article] A polymorphism in the integrin αV subunit gene affects the progression of primary biliary cirrhosis in Japanese patients (2011)
  • Author(s): Inamine T, et al
  • Journal Title: J Gastroenterology Volume: 46(5) Pages: 676-686
  • Peer Reviewed
• [Journal Article] Two missense mutations of the IRF6 gene in two Japanese families with popliteal pterygium syndrome (2010)
  • Author(s): Matsuzawa N, Kondo S, Shimozato K, Nagao T, Nakano M, Tsuda M, Hirano A, Niikawa N, Yoshiura K.
  • Journal Title: Am J Med Genet A Volume: 152A(9) Pages: 2262-7
  • Peer Reviewed
• [Journal Article] Two missense mutations of the IRF6 gene in two Japanese families with popliteal pterygium syndrome. (2010)
  • Author(s): Matsuzawa N, Kondo S, et al
  • Journal Title: Am J Med Genet A Volume: 152 Pages: 2262-2267
  • Peer Reviewed
• [Journal Article] Prevalence and nonrandom distribution of exonic mutations in interferon regulatory factor 6 in 307 families with Van der Woude syndrome and 37 families with popliteal pterygium syndrome (2009)
  • Author(s): de Lima RL, Hoper SA, Ghassibe M, Cooper ME, Rorick NK, Kondo S, Katz L, Marazita ML, Compton J, Bale S, Hehr U, Dixon MJ, Daack-Hirsch S, Boute O, Bayet B, Revencu N, Verellen-Dumoulin C, Vikkula M, Richieri-Costa A, Moretti-Ferreira D, Murray JC, Schutt
  • Journal Title: Genet Med Volume: 11(4) Pages: 241-7
  • Peer Reviewed
• [Journal Article] Polymorphisms of PTPN11 coding SHP-2 as biomarkers for ulcerative colitis susceptibility in the Japanese populaiton (2009)
  • Author(s): Narumi Y, Isomoto H, Shiota M, Sato K, Kondo S, Machida H, Yanagihara K, Mizuta Y, Kohno S, Tsukamoto K.
  • Journal Title: J Clin Immunol Volume: 29(3) Pages: 303-10
  • Peer Reviewed
• [Journal Article] Developmentally dynamic changes of DNA methylation in the mouse Snurf/ Snrpn gene (2009)
  • Author(s): Miyazaki K, Mapendano CK, Fuchigami T, Kondo S, Ohta T, Kinoshita A, Tsukamoto K, Yoshiura K, Niikawa N, Kishino T
  • Journal Title: Gene Volume: 432(1-2) Pages: 97-101
  • Peer Reviewed
• [Journal Article] Strong evidence of a combination polymorphism of the tyrosine kinase 2 gene and the signal transducer and activator of transcription 3 gene as a DNA-based biomarker for susceptibility to Crohn' s disease in the Japanese population (2009)
  • Author(s): Sato K, Shiota M, Fukuda S, Iwamoto E, Machida H, Inamine T, Kondo S, Yanagihara K, Isomoto H, Mizuta Y, Kohno S, Tsukamoto K
  • Journal Title: J Clin Immunol Volume: 29(6) Pages: 815-825
  • Peer Reviewed
• [Journal Article] A further insight into the origin of human T-lymphotropic virus type 1(HTLV-1) in Japan, based on the genotyping of ABCC11 (2009)
  • Author(s): Oshima K, Fujii H, Eguchi K, Otani M, Matsuo T, Kondo S, Yoshiura K, Yamamoto T
  • Journal Title: Tropical Medicine and Health Volume: 37(3) Pages: 121-123
  • NAID: 10025715307
  • Peer Reviewed
• [Journal Article] Prevalence and nonrandom distribution of exonic mutations in interferon regulatory factor 6 in 307 families with Van der Woude syndrome and 37 families with popliteal pterygium syndrome. (2009)
  • Author(s): de Lima RL, et al
  • Journal Title: Genet Med 11(4) Pages: 241-247
  • Peer Reviewed
• [Journal Article] Polymorphisms of PTPN11 coding SHP-2 as biomarkers for ulcerative colitis susceptibility in the Japanese populaiton. (2009)
  • Author(s): Narumi Y, et al
  • Journal Title: J Clin Immunol 29(3) Pages: 303-310
  • Peer Reviewed
• [Presentation] A polymorphism in the proliferation-inducing ligand gene is associated with susceptibility to ulcerative colitis in the Japanese population (2010)
  • Author(s): K Sato
  • Organizer: 18th United European Gastroenterology Week(UEGW)
  • Place of Presentation: in Barcelona, Spain
• [Presentation] Popliteal Pterygium Syndrome患者に由来するIRF6遺伝子変異はその転写活性能を低下させる (2010)
  • Author(s): 岩村直矢, Van der Woude Syndrome
  • Organizer: 日本薬学会第130回年会
  • Place of Presentation: 岡山
• [Presentation] VWS, PPS患者でみられる転写因子IRF6変異は転写活性能を低下させる (2010)
  • Author(s): 岩村直矢
  • Organizer: 第27回日本薬学会九州支部大会
  • Place of Presentation: 長崎
• [Presentation] Diplotype polymorphisms of the salt export pump gene are associated with susceptibility to the progression of primary biliary cirrhosis in Japanese patients (2009)
  • Author(s): Tatsuo Inamine
  • Organizer: 59th American Society of Human Genetics Annual Meeting
  • Place of Presentation: in Honolulu, USA
• [Presentation] A haplotype polymorphism of FUT1 is associated with susceptibility to pulmonary emphysema in the Japanese population (2009)
  • Author(s): Risa Uemura
  • Organizer: 59th American Society of Human Genetics Annual Meeting
  • Place of Presentation: in Honolulu, USA
• [Presentation] The cholesterol 7 alpha-hydroxylase gene susceptible to the severe progression of primary biliary cirrhosis in Japanese patients (2009)
  • Author(s): Shingo Higa
  • Organizer: 59th American Society of Human Genetics Annual Meeting
  • Place of Presentation: in Honolulu, USA
• [Presentation] Evidence of polymorphisms of Xpo1 as a biomarker for susceptibility to anti-tuberculosis drug-induced hepatotoxicity in Japanese patients with tuberculosis (2009)
  • Author(s): Tsutomu Mawatari
  • Organizer: 59th American Society of Human Genetics Annual Meeting
  • Place of Presentation: in Honolulu, USA
• [Presentation] CYP7A1遺伝子は原発性胆汁性肝硬変の重症化感受性遺伝子である (2009)
  • Author(s): 比嘉辰伍
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
• [Presentation] イジュ(Schima wallichii ssp. noronhae)樹皮主成分分析結果 (2009)
  • Author(s): 松尾敏明
  • Organizer: 第50回日本熱帯医学会大会総会
  • Place of Presentation: 沖縄
• [Presentation] Polymorphisms of the genesencoding hepatobiliary transporters are associated with susceptibility to the severe progression of primary biliary cirrhosis in Japanese patients (2009)
  • Author(s): Tatsuo Inamine
  • Organizer: 第3回次世代を担う若手医療薬科学シンポジウム
  • Place of Presentation: 福岡