Role of macrophages in the development and repair of renal injury

• Project/Area Number: 21590600
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied pharmacology
• Research Institution: Osaka City University
• Principal Investigator: MIURA Katsuyuki 大阪市立大学, 医学研究科, 教授 (00183624)
• Co-Investigator(Kenkyū-buntansha): IZUMI Yasukatsu 大阪市立大学, 大学院・医学研究科, 准教授 (10347495)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 薬物治療学 / 腎線維化 / マクロファージ / 樹状細胞 / 樹状組胞

Research Abstract

Tubulointerstitial fibrosis is a main determinant that leads to an irreversible loss of renal function in chronic diseases. The present study was conducted to elucidate the role of mononuclear phagocyte system in the development and repair of renal injury by using mouse unilateral ureteral obstruction. It was found in this animal model that mononuclear phagocytes but not dendritic cells were involved in the development of fibrosis whereas the contribution of these mononuclear phagocytes became less with progression of the disease despite the increase in number of the infiltrating mononuclear cells.

Research Products

• [Journal Article] Renal Fibrosis in Murine Obstructive Nephropathy Is Attenuated by Depletion of Monocyte Lineage, Not Dendritic Cells (2010)
  • Author(s): Y. Machida, K. Kitamoto, Y. Izumi, M. Shiota, J. Uchida, Y. Kira, T. Nakatani, K. Miura
  • Journal Title: Journal of Pharmacological Sciences Volume: 114 Issue: 4 Pages: 464-473
  • DOI: 10.1254/jphs.10246FP
  • NAID: 10029891247
  • ISSN: 1347-8613, 1347-8648
  • Peer Reviewed
• [Journal Article] Effects of conditional ablation of renal dendritic cells on renal fibrosis in obstructive nephropathy (2010)
  • Author(s): Y.Machida, K.Kitamoto, Y.Izumi, M.Shiota, J.Uchida, Y.Kira, T.Nakatani, K.Miura
  • Journal Title: J Pharmacol Sci Volume: 114 Pages: 464-473
  • Peer Reviewed
• [Journal Article] Effects of Liposome Clodronate on Renal Leukocyte Populations and Renal Fibrosis in Murine Obstructive Nephropathy (2009)
  • Author(s): K. Kitamoto, Y. Machida, J. Uchida, Y. Izumi, M. Shiota, T Nakao, H. Iwao, T. Yukimura, T. Nakatani and K. Miura
  • Journal Title: Journal of Pharmacological Sciences Volume: 111 Issue: 3 Pages: 285-292
  • DOI: 10.1254/jphs.09227FP
  • NAID: 10026154246
  • ISSN: 1347-8613, 1347-8648
  • Peer Reviewed
• [Journal Article] Effects of liposome clodronate on renal leukocyte populations and renal fibrosis in murine obstructive nephropathy. (2009)
  • Author(s): K.Kitamoto, Y.Machida, J.Uchida, Y.Izumi, M.Shiota, T.Nakao, H.Iwao, T.Yukimura, T.Nakatani, K.Miura
  • Journal Title: J Pharmacol Sci 111 Pages: 285-292
  • NAID: 10026154246
  • Peer Reviewed
• [Presentation] マウス閉塞性腎症モデルの腎線維化における単球系細胞の役割 (2011)
  • Author(s): 町田裕一, 他
  • Organizer: 第47回日本移植学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2011-10-06
• [Presentation] Depletion of monocyte but not dendritic cells attenuates renal fibrosis in murine obstructive nephropathy (2011)
  • Author(s): Machida Y, et al
  • Organizer: The 12th Congress of the Asian Society of Trans-plantation
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2011-09-27
• [Presentation] Role of renal dendritic cells and macrophages on renal fibrosis in obstructive nephropathy (2011)
  • Author(s): Y. Machida, et al
  • Organizer: 23th International Congress of The Transplantation Society
  • Place of Presentation: Vancouver
  • Year and Date: 2011-08-16
• [Presentation] 樹状細胞選択的除去によるマウス一側尿管閉塞モデルにおける腎線維化の検討 (2010)
  • Author(s): 町田裕一、仲谷達也、三浦克之
  • Organizer: 日本腎臓学会学術総会
  • Place of Presentation: 神戸
  • Year and Date: 2010-06-16
• [Presentation] Effects of conditional ablation of renal dendritic cells on renal fibrosis in obstructive nephropathy (2009)
  • Author(s): Machida Y., Kitamoto K., Nakatani T., Uchida J., Okamura M., Izumi Y, Miura K.
  • Organizer: American Society of Nephrology
  • Place of Presentation: San Diego, USA
  • Year and Date: 2009-10-29
• [Presentation] マウス腎一側尿管閉塞(UUO)モデルにおけるLiposome Clodronateの腎間質線維化抑制効果の検討 (2009)
  • Author(s): 北本興市郎, 他
  • Organizer: 第45回日本移植学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-09-16
• [Presentation] Effects of conditional depletion of renal dendritic cells on renal fibrosis in obstructive nephropathy
  • Author(s): Y. Machida, et al
  • Organizer: 2009 American Society of Nephrology Renal Week
  • Place of Presentation: San Diego