| Project/Area Number |
21590601
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Iwate Medical University |
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Principal Investigator |
IRIE Yasuyuki 岩手医科大学, 医学部, 准教授 (70303948)
|
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| Co-Investigator(Renkei-kenkyūsha) |
TAIRA Eiichi 岩手医科大学, 医学部薬理学講座, 教授 (60263240)
KONDO Yukiko 岩手医科大学, 医学部薬理学講座, 助教 (70347847)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 遺伝子 / 神経科学 / 脳・神経 / 薬理学 / 薬物依存 |
|---|
| Research Abstract |
This study was initiated for the purpose to explore the possibility to elucidate the molecular mechanism of drug dependence, such as psychostimulants, to treat or prevent this. When Neuro2a cells were transfected by Amida, a component of the chromatin remodeling complex, and its related proteins, it turned out that the proliferation rate and adhesion ability were affected. These results were caused because the expression of genes for specific cellar functions were altered. Meanwhile, it was revealed that cell death through the endoplasmic reticulum stress was induced by methamphetamine treatment of the CATH. a cells, a cell line derive from dopaminergic neurons in central nervous system.
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