| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
To clarify electrophysiological properties of the pulmonary vein(PV), we assessed its electrical activity and responses to drugs affecting intracellular Ca^<2+> concentration or ion-channel functions, which were compared with those in the atrium. In this study, triggered activity was induced by train stimulation in the PV, which was not observed in the left atrium. It is presumed that the less negative resting membrane potential in the PV cardiomyocytes induced Ca^<2+> overload during train stimulation, leading to generation of triggered activity. Activation of muscarinic receptors or GIRK channels, which could hyperpolarize the resting membrane potential of the PV, may become a pharmaceutical molecular target for strong suppression of the generation of triggered activity.
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