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The role of renal catecholamine in the progression on acute kidney injury in rats

Research Project

Project/Area Number 21590603
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied pharmacology
Research InstitutionOsaka Ohtani University

Principal Investigator

YUKIMURA Tokihito  大阪大谷大学, 薬学部, 教授 (10145774)

Research Collaborator YAMAGATA Masayo  大阪大谷大学, 薬学部, 講師 (50454583)
TSUTSUI Hidenobu  大阪大谷大学, 薬学部, 助教 (30434806)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords薬物治療学 / 急性腎不全 / 腎虚血再灌流障害 / ノルエピネフリン / 活性酸素種 / モノアミンオキシターゼ / 慢性腎臓病
Research Abstract

We have found that increases in renal sympathetic nerve activity during ischemic period and renal venous norepinephrine(NE) level after reperfusion play important roles in the development of ischemia/reperfusion(I/R)-induced acute kidney injury. In the present study, we examined the effect of isatin, an endogenous monoamine oxidase(MAO) inhibitor, moclobemide, a selective MAO_A inhibitor, and selegiline, a selective MAO_B inhibitor, on renal venous NE levels, superoxide(O_2^-) production after reperfusion and I/R-induced acute kidney injury. I/R-induced acute kidney injury was made by clamping the left renal artery and vein for 45 min followed by reperfusion, 2 weeks after the contralateral nephrectomy. Injection of isatin or moclobemide before ischemia increased the renal venous plasma NE level after reperfusion and aggravated I/R-induced renal injury, but not selegiline administration. The excessive O_2^-production after reperfusion was significantly suppressed by injection of all drugs, indicating that the inhibition of oxidative deamination effectively suppressed O_2^-production. Therefore, the aggravation effect of isatin seems to be mediated through increased NE levels in the kidney after reperfusion on I/R-induced acute kidney injury.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (20 results)

All 2012 2011 2010 2009

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (13 results) Book (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Protective effect of 17ss-estradiol on ischemic acute kidney injury through the renal sympathetic nervous system2012

    • Author(s)
      Tanaka R, Tsutsui H, Kobuchi S, Sugiura T, Yamagata M, Ohkita M, Takaoka M, Yukimura T, Matsumura Y
    • Journal Title

      Eur. J. Pharmacol

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protective effect of 17β-estradiol on ischemic acute kidney injury through the renal sympathetic nervous system2012

    • Author(s)
      Tanaka R
    • Journal Title

      Eur.J.Pharmacol

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 「治験に求められるバイオマーカーとしてのPETを考える勉強会」からの提言2010

    • Author(s)
      伊藤勝彦、植田真一郎、熊谷雄治、雪村時人、志賀剛、佐藤岳幸、劉世玉、稲野彰洋、柏木利次、中野重行、千田道雄、塚田秀夫、鳥山裕司、渡邉裕司
    • Journal Title

      臨床薬理

      Volume: 41 Pages: 233-243

    • NAID

      10027754407

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Moxonidine prevents ischemia/reperfusion-induced renal injury in rats2009

    • Author(s)
      Tsutsui H, Sugiura T, Hayashi K, Ohkita M, Takaoka M, Yukimura T, Matsumura Y
    • Journal Title

      Eur. J. Pharmacol

      Volume: 603 Pages: 73-78

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] Attenuated megalin expression in hyperfunctioning parathyroid tumor2011

    • Author(s)
      Masayo Yamagata
    • Organizer
      第2回IOF/ANZBMS/JSBMR(国際骨粗鬆症財団,オーストラリア・ニュージーランド骨代謝学会・日本骨代謝学会合同学会)
    • Place of Presentation
      オーストラリア・ゴールドコースト
    • Year and Date
      2011-09-05
    • Related Report
      2011 Final Research Report
  • [Presentation] Attenuated megalin expression in hyperfunctioning parathyroid tumors2011

    • Author(s)
      Masayo Yamagata
    • Organizer
      第2回IOF/ANZBMS/JSBMR(国際骨粗鬆症財団、オーストラリア・ニュージーランド骨代謝学会・日本骨代謝学会合同学会)
    • Place of Presentation
      オーストラリア・ゴールドコースト
    • Year and Date
      2011-09-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] メガリンは病的副甲状腺で発現が低下する2011

    • Author(s)
      山形雅代
    • Organizer
      第29回日本骨代謝学会年会
    • Place of Presentation
      大阪
    • Year and Date
      2011-07-30
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 腎虚血再灌流障害の性差における腎交感神経系の関与について2011

    • Author(s)
      筒居秀伸
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-23
    • Related Report
      2011 Final Research Report
  • [Presentation] 虚血性急性腎障害に対する17ss-エストラジオールの腎交感神経系を介した保護効果について2011

    • Author(s)
      田中亮輔
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 腎虚血再灌流障害の性差における腎交感神経系の関与について2011

    • Author(s)
      筒居秀伸
    • Organizer
      第84回 日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜(誌上開催)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 虚血性急性腎障害に対する17β-エストラジオールの腎交感神経系を介した保護効果について2011

    • Author(s)
      田中亮輔
    • Organizer
      第84回 日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜(誌上開催)
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラット腎虚血再灌流障害に対する内因性モノアミンオキシダーゼ阻害物質イサチンの効果2010

    • Author(s)
      三浦健
    • Organizer
      第130年会日本薬学会年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-30
    • Related Report
      2011 Final Research Report
  • [Presentation] ラット腎虚血再灌流障害に対する内因性モノアミンオキシダーゼ阻害物質イサチンの効果2010

    • Author(s)
      三浦健
    • Organizer
      第130年会 日本薬学会年会
    • Place of Presentation
      桃太郎アリーナ(岡山県)
    • Year and Date
      2010-03-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 腎虚血再灌流障害に対するモノアミンオキシターゼ阻害薬の効果2010

    • Author(s)
      筒居秀伸
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 腎虚血再灌流障害に対する虚血性プレコンディショニング処置の腎交感神経系を介した保護効果について2010

    • Author(s)
      田中亮輔
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 腎虚血再灌流障害に対するモノアミンオキシターゼ阻害薬の効果2010

    • Author(s)
      筒居秀伸
    • Organizer
      第83回 日本薬理学会年会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2010-03-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 腎虚血再灌流障害に対する虚血性プレコンディショニング処置の腎交感神経系を介した保護効果について2010

    • Author(s)
      田中亮輔
    • Organizer
      第83回 日本薬理学会年会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2010-03-16
    • Related Report
      2009 Annual Research Report
  • [Book] 循環器の薬理学-薬物による生体機能の修飾と臨床使用(ベッドサイドのBasic Cardiology)2009

    • Author(s)
      岩尾洋, 雪村時人
    • Total Pages
      263
    • Publisher
      メディカルサイエンスインターナショナル
    • Related Report
      2011 Final Research Report
  • [Book] 循環器の薬理学-薬物による生体機能の修飾と臨床使用-(ベッドサイドの Basic Cardiology)2009

    • Author(s)
      岩尾洋, 雪村時人
    • Total Pages
      263
    • Publisher
      メディカルサイエンスインターナショナル
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 腎障害の治療又は予防薬2011

    • Inventor(s)
      筒居秀伸、雪村時人
    • Industrial Property Rights Holder
      学校法人大谷学園
    • Filing Date
      2011-11-18
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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