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Pathogenesis of tissue remodeling caused by endogenous AGE and advanced targeting therapy

Research Project

Project/Area Number 21590604
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied pharmacology
Research InstitutionShujitsu University

Principal Investigator

MORI Shuji  就実大学, 薬学部, 教授 (50220009)

Co-Investigator(Kenkyū-buntansha) GOMITA Yutaka  就実大学, 薬学部, 教授 (00088709)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords臨床薬理学 / 組織リモデリング / 分子標的薬
Research Abstract

The protein array analysis with endogenous AGE as specific probe showed some high affinity binding factors for endogenous AGE, suggesting the formation of pathophysiological cluster in the local site of inflammatory. In addition, we succeeded the establishment of in vitro binding assay between recombinant endogenous AGE and RAGE. Also, Cell-based assay upon NF-kB activation and proinflammatory cytokine production was developed, providing the convenient platform for exploration of specific antagonist to endogenous AGE.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (17 results)

All 2012 2011 2010 2009

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (3 results)

  • [Journal Article] Anti-high mobility group box-1 monoclonal antibody protects the blood-brain barrier from ischemia-induced disruption in rats2011

    • Author(s)
      Zhang J, Takahashi HK, Liu K, Wake H, Liu R, Maruo T, Date I, Yoshino T, Ohtsuka A, Mori S, Nishibori M
    • Journal Title

      Stroke

      Volume: 42 Issue: 5 Pages: 1420-1428

    • DOI

      10.1161/strokeaha.110.598334

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] High-mobility group box protein 1 neutralization reduces development of diet-induced atherosclerosis in apolipoprotein e-deficient mice2011

    • Author(s)
      Kanellakis P, Agrotis A, Kyaw TS, Koulis C, Ahrens I, Mori S, Takahashi HK, Liu K, Peter K, Nishibori M, Bobik A
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 31 Issue: 2 Pages: 313-319

    • DOI

      10.1161/atvbaha.110.218669

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ciprofloxacin inhibits advanced glycation end products-induced adhesion molecule expression on human monocytes2010

    • Author(s)
      Mori S, Takahashi HK, Liu K, Wake H, Zhang J, Liu R, Yoshino T, Nishibori M
    • Journal Title

      Br J Pharmacol

      Volume: 161 Issue: 1 Pages: 229-240

    • DOI

      10.1111/j.1476-5381.2010.00880.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of nicotine on advanced glycation end product-induced immune response in human monocytes2010

    • Author(s)
      Takahashi HK, Liu K, Wake H, Mori S, Zhang J, Liu R, Yoshino T, Nishibori M
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 332 Issue: 3 Pages: 1013-1021

    • DOI

      10.1124/jpet.109.160861

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin E_2 inhibits advanced glycation end product-induced adhesion molecule expression on monocytes, cytokine production, and lymphocyte proliferation during human mixed lymphocyte reaction2010

    • Author(s)
      Takahashi HK, Zhang J, Mori S, Liu K, Wake H, Liu R, Sadamori H, Matsuda H, Yagi T, Yoshino T, Nishibori M
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 334 Issue: 3 Pages: 964-972

    • DOI

      10.1124/jpet.110.169102

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ciprofloxacin inhibits advanced glycation end products-induced adhesion molecule expression on human monocytes2010

    • Author(s)
      Mori S
    • Journal Title

      Brit J Pharmacol

      Volume: 161 Pages: 229-240

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of nicotine on advanced glycation end products-induced immune response in human monocytes2010

    • Author(s)
      Takahashi HK
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 332 Pages: 1013-1021

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin E_2 inhibits advanced glycation end product-induced adhesion molecule expression on monocytes, cytokine production and lymphocyte proliferation during human mixed lymphocyte reaction2010

    • Author(s)
      Takahashi HK
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 334 Pages: 964-972

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin E2 inhibits advanced glycation end product-induced adhesion molecule expression, cytokine production, and lymphocyte proliferation in human peripheral blood mononuclear cells2009

    • Author(s)
      Takahashi HK, Liu K, Wake H, Mori S, Zhang J, Liu R, Yoshino T, Nishibori M
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 331 Issue: 2 Pages: 656-670

    • DOI

      10.1124/jpet.109.157594

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Histamine inhibits advanced glycation end products-induced adhesion molecule expression on human monocytes2009

    • Author(s)
      Wake H, Takahashi HK, Mori S, Liu K, Yoshino T, Nishibori M
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 330 Issue: 3 Pages: 826-833

    • DOI

      10.1124/jpet.109.155960

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Advanced glycation end products subspecies-selectively induce adhesion molecule expression and cytokine production in human peripheral blood mononuclear cells2009

    • Author(s)
      Takahashi HK, Mori S, Wake H, Liu K, Yoshino T, Ohashi K, Tanaka N, Shikata K, Makino H, Nishibori M
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 330 Issue: 1 Pages: 89-98

    • DOI

      10.1124/jpet.109.150581

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin E2 inhibits advanced glycation end product-induced adhesion molecule expression, cytokine production, and lymphocyte proliferation in human peripheral blood mononuclear cells2009

    • Author(s)
      Takahashi HK
    • Journal Title

      J Pharmacol Exp Ther 331

      Pages: 656-670

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histamine inhibits advanced glycation end products-induced adhesion molecule expression on human monocytes2009

    • Author(s)
      Wake H
    • Journal Title

      J Pharmacol Exp Ther 330

      Pages: 826-833

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Advanced glycation end products subspecies-selectively induce adhesion molecule expression and cytokine production in human peripheral blood mononuclear cells2009

    • Author(s)
      Takahashi HK
    • Journal Title

      J Pharmacol Exp Ther 330

      Pages: 89-98

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] アレイ解析によるHMGB1相互作用因子の網羅的探索2012

    • Author(s)
      森秀治
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 治療分子標的としてのHMGB1と創薬2012

    • Author(s)
      森秀治
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 抗HMGB1抗体の結合特異性と機能解析2010

    • Author(s)
      森秀治
    • Organizer
      第49回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      米子
    • Related Report
      2011 Final Research Report 2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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