| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
The protein array analysis with endogenous AGE as specific probe showed some high affinity binding factors for endogenous AGE, suggesting the formation of pathophysiological cluster in the local site of inflammatory. In addition, we succeeded the establishment of in vitro binding assay between recombinant endogenous AGE and RAGE. Also, Cell-based assay upon NF-kB activation and proinflammatory cytokine production was developed, providing the convenient platform for exploration of specific antagonist to endogenous AGE.
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