Analysis of mechanism to escape from immune surveillance in tumor
| Project/Area Number |
21590608
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Hokkaido University |
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Principal Investigator |
YOSHIDA Shigeru 北海道大学, 大学院・保健科学研究院, 助教 (20431314)
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| Co-Investigator(Kenkyū-buntansha) |
FUGO Kazunori 北海道大学, 大学院・医学研究科, 助教 (20431306)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 免疫 / NKG2D / H60c / 可溶型NKG2Dリガンド / DETCs |
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| Research Abstract |
Soluble ligands for NKG2D are involved in escape from immune surveillance in tumor. In this study, soluble H60c (sH60c), NKG2D ligand expressed mainly in skin, was detected in skin tumor and was significantly induced in skin carcinoma. To detect sH60c protein, two monoclonal antibodies specific for H60c were generated and developed ELISA system for sH60c by using these Abs. This study is expected to be helpful in a better understanding of mechanisms to escape from immune surveillance in tumor and useful for development of novel immune therapy.
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Report
(4 results)
Research Products
(15 results)
