Lysophospholipid signal molecules act as determinants of conflicting actions of the lipoproteins.

• Project/Area Number: 21590610
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Takasaki University of Health and Welfare (2010-2011); Gunma University (2009)
• Principal Investigator: KUWABARA Atsushi 高崎健康福祉大学, 保健医療学部, 准教授 (90323344)
• Co-Investigator(Renkei-kenkyūsha): OKAJIMA Fumikazu 群馬大学, 生体調節研究所, 教授 (30142748)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: LDL / HDL / スフィンゴシン1-リン酸 / リゾホスファチジン酸 / 動脈硬化 / S1P / LPA / SlP

Research Abstract

The aim of this study was to investigate the antiatherogenic actions of lysophospholipid contained in lipoproteins. In the endothelial cells, the antiatherogenic actions of HDL was mediated through two signaling pathways, both sphingosine 1-phosphate(S1P)/S1P receptors and Apo A/scavenger receptor class B type I receptors(SR-BI). LDL inhibited the signal transduction system of Apo A/SR-BI, but not S1P/S1P receptors. The antiatherogenic action of S1P contained in HDL was not inhibited by LDL.

Research Products

• [Journal Article] Mechanism and role of high density lipoprotein-induced activation of AMP-activated protein kinase in endothelial cells (2010)
  • Author(s): DS, Kuwabara A, Mogi C, Itoh H, Kurose H, Murakami M, Okajima F
  • Journal Title: J Biol Chem Volume: 285(7) Pages: 4387-97
  • Peer Reviewed
• [Journal Article] Mechanism and role of high density lipoprotein-induced activation of AMP-activated protein kinase in endothelial cells. (2010)
  • Author(s): Kimura T, Tomura H, Sato K, Ito M, Matsuoka I, Im DS, Kuwabara A, Mogi C, Itoh H, Kurose H, Murakami M, Okajima F.
  • Journal Title: J Biol Chem. 285(7) Pages: 4387-97
  • Peer Reviewed
• [Presentation] HDLの血管内皮細胞保護作用に対するLDLの作用の解析 (2010)
  • Author(s): 桑原敦志、木村孝穂他
  • Organizer: 第57回日本臨床検査医学会学術集会
  • Place of Presentation: 京王プラザホテル
  • Year and Date: 2010-09-12