| Project/Area Number |
21590611
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
TOZUKA Minoru 東京医科歯科大学, 大学院・保健衛生学研究科, 教授 (60431954)
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| Research Collaborator |
HONDA Takayuki 信州大学, 医学部, 教授 (80238815)
ISOBE Mitsuaki 東京医科歯科大学, 医歯学総合研究科, 教授 (80176263)
KURIHARA Kurihara 東京医科歯科大学, 大学院・保健衛生学研究科, 助教 (70291341)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 臨床化学 / N-ホモシステイン化apoAI / apoAI-apoAII / apoE結合HDL / 抗酸化能 / myeloperoxidase / 修飾apoAI / HDLサブクラス / 粥状硬化症 / Truncated apoAI / cholesterol efflux / 泡沫細胞 / carboxypeptidase A / モノクローナル抗体 / 粥状動脈硬化 / truncated apoAI / キマーゼ / ホモシステイン化 / ELISA |
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| Research Abstract |
We pay attention to truncated and/or modified apolipoprotein AI(apoAI), such as C-terminally truncated apoAI, N-homocysteinylated apoAI, and apoAI-apoAII heterodimer, as the potential candidates of predictive biomarker for cardiovascular disease. We identified those truncated and modified apoAI in nomal human serum and developed the quantitative methods for those candidates. In the preliminary experiment, the possibility that apoAI-apoAII heterodimer would be a useful biomarker for acute myocardial infarction was indicated.
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