Investigation of antithrombotic effects of heme oxygenase-1 on the hypercoagulable state by inflammation or oxidative stress
Project/Area Number |
21590613
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Laboratory medicine
|
Research Institution | Kanazawa University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
YACHIE Akihiro 金沢大学, 医学系, 教授 (40210281)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | ヘムオキシゲナーゼ1 / 血栓 / 組織因子 / プラスミノゲンアクチベーター・インヒビター / 一酸化炭 / クルクミン / ヘムオキシゲナーゼ-1 / PAI-1 / リポポリサッカライド / 一酸化炭素(CO) / NF-κB / 血管内皮細胞 / トロンボモジュリン / 血栓形成 / 一酸化炭素 / ビリルビン |
Research Abstract |
The purpose of the present study was to examine the antithrombotic role of heme oxygenase-1(HO-1) in detail, and to examine whether endothelial HO-1 induced by curcumin or carbon monoxide(CO) endogenously produced by HO-1 contributes to this antithrombotic effect. As a result, CO or endothelial HO-1 induced by curcumin would be effective for the prevention and treatment of hypercoagulable state by inflammation or oxidative stress.
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Report
(4 results)
Research Products
(86 results)