Anti-atherogenicity of increased levels of HDL caused by angiopoietin-like protein gene mutations

• Project/Area Number: 21590616
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Kanazawa University
• Principal Investigator: INAZU Akihiro 金沢大学, 保健学系, 教授 (80293348)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: リポ蛋白 / リパーゼ / 高HDL血症 / アンジオポエチン様蛋白 / 遺伝子変異 / リポ蛋白リパーゼ / CETP欠損 / 遺伝子多型 / 高比重リポ蛋白 / インヒビター / CETP欠損症 / 血管内皮リパーゼ

Research Abstract

Increased levels of plasma HDL is frequently found in~ 1% of general Japanese population. Genetic cause of high HDL levels has been uncertain except CETP deficiency. Plasma angiopoietin-like protein 3 and 4 are known as an intrinsic lipase inhibitor against lipoprotein lipase and endothelial lipase, respectively. Although every exon in these two genes was screened in subjects with increased HDL levels but without CETP deficiency, mutation was not found.

Research Products

• [Journal Article] Novel mutations of cholesteryl ester transfer protein(CETP) gene in Japanese hyperalpha-lipoproteinemic subjects (2012)
  • Author(s): Ohtani R, Inazu A, Noji Y, Wakasugi T, Miwa K, Tada H, Kawashiri M, Noguchi T, Nohara A, Kobayashi J, Koizumi J, Yamagishi M, Mabuchi H
  • Journal Title: Clin Chim Acta Volume: 413 Pages: 537-543
  • NAID: 120004026116
  • Peer Reviewed
• [Journal Article] Novel mutations of cholesteryl ester transfer protein (CETP) gene in Japanese hyperalphalipoproteinemic subjects (2012)
  • Author(s): Ohtani R, et al
  • Journal Title: Clin Chim Acta Volume: 413 Pages: 537-543
  • Peer Reviewed
• [Journal Article] Postprandial lipoproteinmetabolism : VLDL vs chylomicrons (2011)
  • Author(s): Nakajima K, Nakano T, Tokita Y, NagamineT, Inazu A, Kobayashi J, Mabuchi H, Stanhope KL, Havel PJ, Okazaki M, Ai M, Tanaka A
  • Journal Title: Clin Chim Acta Volume: 412 Pages: 1306-1318
  • Peer Reviewed
• [Journal Article] Postprandial lipoprotein metabolism : VLDL vs chylomicrons (2011)
  • Author(s): Nakajima K, et al
  • Journal Title: Clin Chim Acta Volume: 412 Pages: 1306-1308
  • Peer Reviewed
• [Journal Article] 動脈硬化症・炎症性血管病に対する新規治療 (2011)
  • Author(s): 稲津明広
  • Journal Title: 日本臨床 Volume: 69 Pages: 105-109
• [Journal Article] 動脈硬化性疾患予防のための脂質管理について TGとHDLの意義 (2011)
  • Author(s): 稲津明広
  • Journal Title: 更年期と加齢のヘルスケア Volume: 9 Pages: 320-324
• [Journal Article] 高HDLコレステロール血症へどのように対応するか (2010)
  • Author(s): 稲津明広, 小林淳二
  • Journal Title: Medical Practice 脂質異常症-明日からの診療に役立つ最新の知識- 27 Pages: 478-482
• [Journal Article] Cholesterol efflux from J774 macrophages and Fu5AH hepatoma cells to serum is preserved in CETP deficient patients (2009)
  • Author(s): Miwa K, Inazu A, Kawashiri M, Nohara A, Higashikata T, Kobayashi J, Koizumi J, Nakajima K, Nakano T, Niimi M, Mabuchi H, Yamagishi M
  • Journal Title: Clin Chim Acta Volume: 402(1-2) Pages: 19-24
  • Peer Reviewed
• [Journal Article] A deficiency of cholesteryl ester transfer protein whose serum remnant-like particle(RLP)-triglyceride significantly increased, but RLP-cholesterol did not after an oral fat load (2009)
  • Author(s): Ai M, Tanaka A, Shimokado K, Ohtani R, Inazu A, Kobayashi J, Mabuchi H, Nakano T, Nakajima K
  • Journal Title: Ann Clin Biochem Volume: 46 Pages: 457-63
  • Peer Reviewed
• [Presentation] Newly identified cholesteryl ester transfer protein(CETP) gene mutations in Japanese hyperalpha-lipoproteinemia subjects (2012)
  • Author(s): Inazu A
  • Organizer: XVI International Symposium on Atherosclerosis
  • Place of Presentation: Sydney Convention Center(Australia)
  • Year and Date: 2012-03-26
• [Presentation] コレステリルエステル転送蛋白の動脈硬化症に対する意義シンポジウム「HDL分子研究の発展とその臨床応用」 (2011)
  • Author(s): 稲津明広
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2011-09-22
• [Presentation] コレステリルエステル転送蛋白の動脈硬化症に対する意義 (2011)
  • Author(s): 稲津明広
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2011-09-22
• [Presentation] 動脈硬化性疾患予防におけるHDLコレステロール測定の意義 (2010)
  • Author(s): 稲津明広
  • Organizer: 第49回中部地区医学検査学会
  • Place of Presentation: 金沢都ホテル(石川県)(招待講演)
  • Year and Date: 2010-09-18
• [Presentation] 脂質の遺伝子疾患と臨床検査について一遺伝子検査により理解される脂質異常症 (2009)
  • Author(s): 稲津明広
  • Organizer: 日本臨床化学会 脂質・リポ蛋白基礎セミナー
  • Place of Presentation: 長崎 式見ハイツ
  • Year and Date: 2009-09-20
• [Presentation] CETP阻害薬の開発動向プロジェクト報告リポ蛋白検査専門委員会 (2009)
  • Author(s): 稲津明広
  • Organizer: 第49回日本臨床化学会年次学術集会
  • Place of Presentation: 長崎大学医学部(長崎県)
  • Year and Date: 2009-09-18
• [Presentation] Prospect of CETP inhibitor (2009)
  • Author(s): Inazu A
  • Organizer: LVDD's INTERNATIONAL LIPOPROTEIN STANDARDIZATION FORUM, AACC
  • Place of Presentation: Hyatt Regency Chicago Hotel(USA)
  • Year and Date: 2009-07-22
• [Book] Human cholesteryl ester transfer proteinin human HDL metabolismHigh Density Lipoproteins (2010)
  • Author(s): Mabuchi H and Inazu A
  • Publisher: Springer Science
• [Book] Plasma cholesteryl ester transfer protein(CETP) in relation to humanpathophysiology (2010)
  • Author(s): Inazu A
  • Publisher: Elsevier
• [Book] The HDL Handbook, Biological functions and clinical implications Editor Tsugikazu Komoda, Elsevier (2010)
  • Author(s): Inazu A
  • Publisher: Chapter 3.Plasma cholesteryl ester transfer protein (CETP) in relation to human pathophysiology