Podocyte injury induced by chronic hypoxia in diabetic db/db mice
Project/Area Number |
21590617
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Laboratory medicine
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Research Institution | University of Fukui |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
KIMURA Hideki 福井大学, 医学部, 准教授 (20283187)
KASUNO Kenji 福井大学, 医学部附属病院, 助教 (60455243)
YOSHIDA Haruyoshi 福井大学, 医学部, 教授 (80135574)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 糖尿病 / 糖尿病性腎症 / 低酸素 / ポドサイト |
Research Abstract |
We analyzed the glomerular lesion induced by chronic hypoxia in db/db mice. Hypoxia-associated glomerular injury may result from the increased macrophage infiltration via monocyte chemoattractant protein-1(MCP-1), but not from vascular endothelial growth factor-A(VEGF-A).
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Severe intraglomerular detachment of podocytes in a Gitelman syndrome patient2012
Author(s)
Naoki Takahashi, Hideki Kimura, Shinichi Mizuno, Masanori Hara, Yoshiaki Hirayama, Hiroyuki Kurosawa, Shouji Tsutaya, Minoru Yasujima, Seiji Yokoi, Daisuke Mikami, Kenji Kasuno, Hironobu Naiki, Masayuki Iwano and Haruyoshi Yoshida
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Journal Title
Clin Exp Nephrol
Volume: (in press)
Issue: 3
Pages: 16-16
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Tubulointerstitial nephritis with IgM-positive plasmacytoid large lymphocyte infiltration in a patient with primary biliary cirrhosis and Sjoegren's syndrome.2010
Author(s)
Naoki Takahashi, Hideki Kimura, Yumiko Kawajiri, Daisuke Mikami, Chie Yamamoto, Kenji Kasuno, Naofumi Imai, Takeshi Kuroda, Shinichi Nishi, Makoto Yamamoto, Haruyoshi Yoshida.
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Journal Title
Clin Nephrol
Volume: 74
Pages: 74-80
Related Report
Peer Reviewed
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[Journal Article] Acute on chronic subdural hematoma as a rare complication in a microscopic polyangiitis patient receiving antithrombotic treatment2009
Author(s)
Naoki Takahashi, Hideki Kimura, Ryuhei Kitai, Mamiko Sato, Makoto Yoneda, Chie Yamamoto, Daisuke Mikami, Masaru Kuriyama, Toshihiko Kubota, Hiroshi Itoh, and Haruyoshi Yoshida
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Journal Title
Clin Nephrol
Volume: 72
Pages: 211-215
Related Report
Peer Reviewed
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[Journal Article] Acute on chronic subdural hematoma as a rare complication in a microscopic polyangiitis patient receiving antithrombotic treatment2009
Author(s)
Takahashi N, Kimura H, Kitai R, Sato M, Yoneda M, Yamamoto C, Mikami D, Kuriyama M, Kubota T, Itoh H, Yoshida H
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Journal Title
Clin Nephrol 72
Pages: 211-215
Related Report
Peer Reviewed
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[Presentation] 低酸素下のヒト近位尿細管細胞において、グルココルチコイドはPAI-1の産生を増強しVEGFの産生を抑制する2010
Author(s)
鳥居国雄, 木村秀樹, 上山和子, 杉本英弘, 岡田敏春, 山野智子, 関口清美, 三上大輔, 糟野健司, 高橋直生, 吉田治義
Organizer
第57回日本臨床検査医学会
Place of Presentation
東京
Related Report
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